CAS: 54673-07-3; 2-Cyano-3-(3-Hydroxyphenyl)Acrylic Acid

该化合物是一种有机化合物,其独特结构包括一个丙诺组和一个苯基羟基组,其特点是一种固体,由于氢氧基组的存在,极地溶剂中可溶解,可进行氢联结,具有酸性等特性,可归因于碳酸功能组,并可参与各种化学反应,包括核糖核激素添加和凝聚反应.该环体组的存在增强了其再活动性,使其在有机合成中有用,并有可能发展医药或农用化学.此外,该化合物可能展示生物活动,这是研究医药化学的一个领域.其稳定性和再活性可能受到诸如pH和温度等环境因素的影响,因此有必要将这些条件纳入实际应用.

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CAS号100-83-4 间羟基苯甲醛 | CAS号372-09-8 氰基乙酸 | CAS号64-19-7 冰醋酸

合成工艺路线路线简述

    📜间羟基苯甲醛,Alkaline Earth Salt Of/the/ Methylsulfuric Acid置于sodium Hydroxide体系中,化学反应生成 Alpha-氰基-3-羟基肉桂酸
    参考文献:Baker; Lapworth,Journal Of The Chemical Society,1924,Vol. 125,P. 2337
    标题:Baker; Lapworth,Journal Of The Chemical Society,1924,Vol. 125,P. 2337

    海关参考信息

    专利信息


    专利号:US-6531470-B1
    优先权日:1998-01-23
    标题:Oxazolidinone combinatorial libraries, compositions and methods of preparation
    发明人:GORDEEV MIKHAIL F; LUEHR GARY W; PATEL DINESH V; NI ZHI-JIE; GORDON ERIC
    权利人:UPJOHN CO
    摘要:Oxazolidinones and methods for their synthesis are provided. Also provided are combinatorial libraries comprising oxazolidinones, and methods to prepare the libraries. Further provided are methods of making biologically active oxazolidinones as well as pharmaceutically acceptable compositions comprising the oxazolidinones. The methods of library preparation include the attachment of oxazolidinones to a solid support. The methods of compound preparation in one embodiment involve the reaction of an iminophosphorane with a carbonyl containing polymeric support.

    专利号:US-6562844-B2
    优先权日:1998-01-23
    标 题:Oxazolidinone combinatorial libraries, compositions and methods of preparation
    发明人:GORDEEV MIKHAIL F; LUEHR GARY W; PATEL DINESH V; NI ZHI-JIE; GORDON ERIC
    权利人:UPJOHN CO
    摘要:Oxazolidinones and methods for their synthesis are provided. Also provided are combinatorial libraries comprising oxazolidinones, and methods to prepare the libraries. Further provided are methods of making biologically active oxazolidinones as well as pharmaceutically acceptable compositions comprising the oxazolidinones. The methods of library preparation include the attachment of oxazolidinones to a solid support. The methods of compound preparation in one embodiment involve the reaction of an iminophosphorane with a carbonyl containing polymeric support.

    专利号:US-9217012-B2
    优先权日:2009-04-08
    标题 :Inhibitors of protein tyrosine phosphatases
    发明人:ZHANG ZHONG-YIN; ZHANG SHENG
    权利人:ZHANG ZHONG-YIN; ZHANG SHENG; UNIV INDIANA RES & TECH CORP
    摘要:Disclosed herein are compounds that selectively inhibit members of the PTP family of enzymes. Synthesized compounds demonstrated selective inhibition of TC-PTP. Also provided are methods of using the compounds and formulations containing the compounds. Also described is a fluorescence-tagged combinatorial library synthesis and screening method. And methods of using these compounds to effect enzyme activity both in cells and in vitro as well as method of using these compounds to treat diseases in human and animals.

    专利号:US-7002020-B1
    优先权日:1998-01-23
    标题:Oxazolidinone combinatorial libraries, compositions and methods of preparation
    发明人:GORDEEV MIKHAIL F; LUEHR GARY W; PATEL DINESH V
    权利人:UPJOHN CO
    摘要:Oxazolidinones and methods for their synthesis are provided. Also provided are combinatorial libraries comprising oxazolidinones, and methods to prepare the libraries. Further provided are methods of making biologically active oxazolidinones as well as pharmaceutically acceptable compositions comprising the oxazolidinones. The methods of library preparation include the attachment of oxazolidinones to a solid support. The methods of compound preparation in one embodiment involve the reaction of an iminophosphorane with a carbonyl containing polymeric support.

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    合成参考文献


    参考文献:10.1016/j.brainres.2008.11.068
    摘要:Hosoi R, Matsuyama Y, Hirose S, Koyama Y, Matsuda T, Gee A, Inoue O. Characterization of (14)C-acetate uptake in cultured rat astrocytes. Brain Res. 2009 Feb 09;1253():69–73. doi: 10.1016/j.brainres.2008.11.068.
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