CAS: 54-05-7; N4-(7-Chloroquinolin-4-yl)-N1,N1-Diethylpentane-1,4-Diamine

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CAS号98519-65-4 4-溴-7-氯喹啉 | CAS号140-80-7 2-氨基-5-二乙氨基戊烷 | CAS号50-63-5 磷酸氯喹 | CAS号86-99-7 7-氯-4-羟基喹啉 | CAS号108-42-9 间氯苯胺 | CAS号86-47-5 7-氯-4-羟基喹啉-3-羧酸 | CAS号16600-22-9 4-羟基-7-氯喹啉-3-羧酸乙酯 | CAS号3412-99-5 2-(((3-氯苯基)氨基)亚... | CAS号114422-77-4 uroporphyrin I-... | CAS号86-98-6 4,7-二氯喹啉 | CAS号1476-52-4 去乙基氯喹

📜3-氯苯胺置于4,4'-二甲氧基-2,2'-联吡啶,氧气,Copper Diacetate,Palladium Diacetate,三甲基乙酸体系中,用 甲苯 作为反应溶剂,化学反应生成 氯喹
参考文献:Pd/cu协同催化有氧脱氢芳构化制备4-氨基喹啉衍生物
标题:Pd/cu协同催化有氧脱氢芳构化制备4-氨基喹啉衍生物
摘要:4-氨基喹啉部分广泛存在于各种生物活性化合物和市售药物中,而该目标结构的制备很大程度上依赖于4-氯喹啉的胺化.在此,基于有氧脱氢芳构化策略开发了原子和步骤经济程序.与众所周知的钯催化环己酮与胺的脱氢芳构化不同,协同 Pd/cu 催化对于 2,3-二氢喹啉-4(1 H)-One 类型的底物至关重要.在优化条件下,一系列芳香族/脂肪族胺和2,3-二氢喹啉-4(1H)-酮偶联,以中等到高收率得到相应的4-氨基喹啉产物,并应用当前的方法还展示了上市药物的制备和后期多样化.
DOI:10.1021/acs.Joc.3C01400

专利信息

专利号:US-10968174-B2
优先权日:2016-12-21
标题:Synthesis of a thiosulfonic acid by a step of periodate mediated oxidative coupling of a thiosulfonic acid with an aniline
发明人：SINCLAIR JAMES PETER; NICOLL SARAH LOUISE; STOREY JOHN MERVYN DAVID; LARCH CHRISTOPHER PAUL
权利人:WISTA LAB LTD
摘要:The present invention pertains generally to the field of chemical synthesis, and more particularly to methods for the chemical synthesis of a thiosulfonic acid of Formula (1) by a step of periodate mediated oxidative coupling of a thiosulfonic acid of Formula (2) with an aniline of Formula (3), as described herein. The present invention also relates to such methods which incorporate one or more additional (subsequent and/or preceding) steps, for example, to prepare compounds of Formula (5) from compounds of Formula (1); to prepare compounds of Formula (6) from compounds of Formula (5); and to prepare compounds of Formula (2) from compounds of Formula (4), as described herein.

专利号:US-11672829-B2
优先权日:2015-09-10
标 题:Genetically engineered coronavirus-specific effector cells for in situ synthesis of antiviral proteins
发明人：BHATNAGAR PARIJAT; SSEMADAALI MARVIN A
权利人:STANFORD RES INST INT
摘要:An example genetically engineered effector cell comprises an exogenous polynucleotide sequence that includes a receptor element, an actuator element, and an effector element. The receptor element encodes a chimeric antigen receptor (CAR) comprising an extracellular antigen binding domain operably linked to a transmembrane domain, and an intracellular signaling domain, wherein the extracellular antigen binding domain recognizes an antigen on a surface of a Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2)-infected cell. The actuator element encodes a transcription factor binding site that upregulates synthesis of an antiviral protein. The effector element encodes the antiviral protein operably linked to a signal peptide, wherein, in response to the antigen binding domain of the CAR binding to the antigen of SARS-CoV-2-infected cell, the engineered effector cell is configured to activate and, to synthesize and secrete the antiviral protein.

专利号:US-5703223-A
优先权日:1994-09-02
标题 :Solid phase synthesis of oligonucleotides with stereospecific substituted phosphonate linkages by pentavalent grignard coupling
发明人：WICKSTROM ERIC; LE BEC CHRISTINE
权利人:UNIV JEFFERSON
摘要:The present invention provides a method for producing an oligonucleotide having stereospecific substituted phosphonate linkages by use of a pentavalent Grignard coupling reaction on a solid phase support. The method can be used for automated synthesis of oligonucleotides having sequential equatorial or axial stereospecific substituted phosphonate linkages.

专利号:WO-2006046949-A1
优先权日:2004-10-22
标 题 :SYNTHESIS AND ANTIMALARIAL ACTIVITY OF PYRROLO[3,2-f]QUINAZOLINE-1,3- DIAMINE DERIVATIVES
发明人：AI J LIN; JIAN GUAN; QUAN ZHANG; SKILLMAN DONALD R
权利人:WALTER REED ARMY INST OF RES W; AI J LIN; JIAN GUAN; QUAN ZHANG; SKILLMAN DONALD R
摘要:The invention relates to derivatives of pyrroloquinazolinediamine, more specifically derivatives of 7-(substituted)-7H-pyrrolo[3,2-F] quinazoline-1,3-diamines that are non-toxic and are also effective in the treatment of malaria, including P. falciparum and P.vivax strains. The derivatives are certain carbamate derivatives, succinimide derivatives, alkylcarboxamides derivatives and acetamide derivative, phthalimides, alkylamines and all other amide and imide derivatives and their 1-hydroxy analogs,. The derivatives of the present invention are also soluble in common organic solvents to facilitate the purification in a large scale synthesis of the composition.

专利号:US-8497375-B2
优先权日:2010-06-11
标 题 :Method of synthesis of ferroquine by convergent reductive amination
发明人：FEREY VINCENT; MATEOS-CARO JULIA; MONDIERE REGIS; VAYRON PHILIPPE; VIGNE SYLVIE
权利人:SANOFI SA
摘要:The invention relates to a method of synthesis of ferroquine of formula (F) or of its metabolite of formula (Fm): n n n n n n n n n n n n comprising a reaction of reductive amination, said reaction comprising: n (i) a stage of condensation of an aldehyde-amino ferrocene of formula (III), in which R represents a hydrogen atom or a methyl group, with 7-chloroquinolin-4-amine as shown below, n n n n n n n n n n n n n n n n followed by n (ii) a stage of reduction of the product of condensation obtained in the preceding stage and n (iii) then a stage of hydrolysis of the reaction mixture in the presence of an aqueous solution of ammonia or of citric acid.

专利号:US-12391691-B2
优先权日:2018-11-16
标题:Synthesis of key intermediate of KRAS G12C inhibitor compound
发明人：PARSONS ANDREW THOMAS; COCHRAN BRIAN MCNEIL; POWAZINIK IV WILLIAM; CAPORINI MARC ANTHONY
权利人:AMGEN INC
摘要:The present invention relates to an improved, efficient, scalable process to prepare intermediate compounds, such as compound 5M, having the structure n nuseful for the synthesis of compounds that target KRAS G12C mutations, such as