CAS: 50-10-2; Oxyphenonium Bromide

该化合物是一种合成抗胆碱基剂,主要用作抗呼吸系统药物;它的作用是抑制肌肉受体的乙酰胆碱化作用,导致肌肉萎缩的减少,特别是胃肠道和小便系统;这种化合物的施用通常以其溴盐的形式进行,这提高了其溶性性和生物利用率;氧化苯基溴的特点是它能够缓解与诸如胃溃疡和肠胃炎综合症等条件有关的症状;它也可以用于管理膀胱炎;该物质一般都受到很好的调制,但潜在的副作用包括口干,视力模糊,凝固和尿液保留,因为其抗胆碱性特性;同任何药物一样,它对于在医学监督下使用氧苯基溴以监测不良效应和与其他药物的相互作用至关重要;其化学结构包括一个苯基胺组和一个肾基胺基,有助于其药性活动.

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CAS号1603-79-8 苯甲酰甲酸乙酯 | CAS号31197-69-0 2-环己基-2-羟基苯乙酸乙酯 | CAS号4335-77-7 2-环己基-2-羟基苯乙酸 | CAS号931-50-0 环己基溴化镁 | CAS号74-83-9 溴甲烷 | CAS号3570-96-5 cyclohexyl-hydr...

合成工艺路线路线简述

    📜环己基溴化镁置于potassium Carbonate,乙酸乙酯体系中,化学反应生成 奥芬溴铵
    参考文献:关于碱性酯iii的表示
    标题:关于碱性酯iii的表示
    摘要:
    DOI:10.1002/hlca.19470300136

    海关参考信息

    专利信息


    专利号:US-6140529-A
    优先权日:1998-10-22
    标 题 :Synthesis of optically active cyclohexylphenylglycolate esters
    发明人：BAKALE ROGER P; LOPEZ JORGE L; MCCONVILLE FRANCIS X; VANDENBOSSCHE CHARLES P; SENANAYAKE CHRIS HUGH
    权利人:SEPRACOR INC
    摘要:A process for the preparation of optically active cyclohexylphenylglycolate esters is described. The process utilizes carboxylic acid activation to couple (R)- or (S)-cyclohexylphenylglycolic acid (CHPGA) with 4-N,N-diethylamino butynol or other propargyl alcohol derivatives. The preparation of the hydrochloride salt is also described. In addition, a resolution process employing tyrosine methyl ester enantiomers for preparing a single enantiomer of CHPGA from racemic CHPGA is disclosed.

    专利号:WO-0023414-A2
    优先权日:1998-10-22
    标题:Synthesis of optically active cyclohexylphenylglycolic acid and its esters

    专利号:AU-2003271292-A2
    优先权日:1998-10-22
    标 题 :Synthesis of optically active cyclohexylphenylglycolic acid and its esters

    专利号:AU-2003271292-A1
    优先权日:1998-10-22
    标题:Synthesis of optically active cyclohexylphenylglycolic acid and its esters

    专利号:US-6025177-A
    优先权日:1998-03-30
    标题 :Asymmetric grignard synthesis with cyclic 1,2 aminoalcohols
    发明人：SENANAYAKE CHRIS HUGH; BAKALE ROGER P; FANG QUN KEVIN; GROVER PAUL TIMOTHY; HEEFNER DONALD L; ROSSI RICHARD F; WALD STEPHEN ALAN
    权利人:SEPRACOR INC
    摘要:Processes for preparing a single enantiomer of an alpha , alpha -disubstituted- alpha -hydroxy acetic acid, especially cyclohexylphenylglycolic acid (CHPGA), is disclosed. The processes employ cyclic 1,2-aminoalcohols as chiral auxiliaries by forming diastereomeric esters of aminoalcohols or diastereomeric amides of oxazolidines. Intermediates useful in the process are also disclosed.

    专利号:EP-1424321-B1
    优先权日:1998-10-22
    标题 :Synthesis of optically active cyclohexylphenylglycolate esters

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    主要参考文献


    1: El-Gindy A, Emara S, Shaaban H. Stability-indicating method for determination of oxyphenonium bromide and its degradation product by high-performance liquid chromatography. J AOAC Int. 2007 Sep-Oct;90(5):1250-7. 1(2):166-72. doi: 10.1021/mp034005p. 90(6):740-8. doi: 10.1002/jps.1030. 121(1):47-63. Japanese. doi: 10.1248/yakushi.121.47. 88(8):759-62. doi: 10.1021/js990026s. 71(9):1733-6. doi: 10.1021/ac981286h. 47(7):869-72. 41(2):183-4. 39(2):163-5. 2(3):232-8. doi: 10.1016/s1076-6332(05)80171-0. 146(2 ( Pt 2)):660-2. doi: 10.1016/s0022-5347(17)37887-4. 10(5):221-3. doi: 10.1007/BF01956875. 25(6):683-7. doi: 10.1111/j.1365-2125.1988.tb05253.x.
    14: Gupta B, Singh AK, Crowell SB. A comparative study of cimetidine, ranitidine & combination of ranitidine with oxyphenonium bromide in inhibition of nocturnal gastric secretion. Indian J Med Res. 1987 Nov;86:635-40. 68(12):649-53. 26(4):435-41. doi: 10.1007/BF00542137. 282(3):120-4. doi: 10.1097/00000441-198111000-00004.
    35:243-9. Polish. 13(5):325-9. doi: 10.1007/BF00644603.

    合成参考文献

    合成方法参考DOI号:10.1021/ac981286h
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