CAS: 492-87-5; Julocrotine
- 英文名称Julocrotine
- 中文名称N-[2,6-二氧代-1-(2-苯基乙基)-3-哌啶基]-2-甲基丁烷酰胺
- IUPAC名称(S)-N-((S)-2,6-dioxo-1-phenethylpiperidin-3-yl)-2-methylbutanamide
- 其它别名Julocrotine; N-[2,6-Dioxo-1-(2-Phenylethyl)-3-Piperidinyl]-2-Methylbutanamide; Butanamide, N-[(3S)-2,6-Dioxo-1-(2-Phenylethyl)-3-Piperidinyl]-2-Methyl-, (2S)-; Julocrotonine
- CAS编号492-87-5
- FDA UNII编号:EX3I778P4B
- 分子式:C18H24N2O3分子量:316.4
- 产品CID: 1480914
- 产品分类有机原料 → 有机酸及其衍生物 → 羧酸及其衍生物
物理性质
MSDS等安全信息
上下游产品
(3S)-3-Amino-1-(2-Phenylethyl)Piperidine-2,6-Dione 1175950-31-8Phenylmethyl (3S)-[2,6-Dioxo-1-(2-Phenylethyl)-3-Piperidinyl]Carbamate 1304774-09-1
合成工艺路线路线简述
📜(S)-N-((S)-2,6-Dioxo-1-Phenethylpiperidin-3-yl)-N-((R)-1-(4-Methoxyphenyl)Ethyl)-2-Methylbutanamide置于三氟乙酸体系中,化学反应 24.17H,以96%的收率获得产物n-[2,6-二氧代-1-(2-苯基乙基)-3-哌啶基]-2-甲基丁烷酰胺
参考文献:通过多组分反应化学制备戊二酰亚胺生物碱
标题:通过多组分反应化学制备戊二酰亚胺生物碱
摘要:介绍了具有高度生物学意义的戊二酰亚胺生物碱的简洁四步合成路线.通过 Ugi 四组分反应访问支架,从而引入两个变化点.接着是水解,温和条件下的环化和胺脱保护.环化中间体的非对映异构体很容易分离,从而得到光学纯的生物碱.通过这条路线,合成了四种天然产物和十种衍生物.研究了合成方法的范围和局限性.
DOI:10.1002/ejoc.201801276
海关参考信息
- 2902600000-乙苯
2912110000-甲醛
2912120000-乙醛
2921211000-乙二胺 - 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
- 详情请参考：📖 海关编码查询和海关进出口税则
专利信息
专利号:WO-2012002913-A1
优先权日:2010-07-02
标 题:Process of forming a cyclic imide
发明人：HONG SOON HYEOK; ZHANG JIAN; MUTHAIAH SENTHILKUMAR; GHOSH SUBHASH CHANDRA
权利人:UNIV NANYANG TECH; HONG SOON HYEOK; ZHANG JIAN; MUTHAIAH SENTHILKUMAR; GHOSH SUBHASH CHANDRA
摘要:A process is provided for the synthesis of a cyclic imide. A primary amine and a diol compound are contacted in the presence of a Ruthenium (II) complex. The Ruthenium (II) catalyst includes at least one of an alicyclic ligand, an aromatic ligand, an arylalicyclic ligand, an arylaliphatic ligand and a phosphine ligand.
供应商参考报价(招募中)
品牌试剂参考报价(招募中)
📌 第三方产品分析报告
主要参考文献
1: Ndunda B, Langat MK, Wanjohi JM, Midiwo JO, Kerubo LO. Alienusolin, a new 4α-deoxyphorbol ester derivative, and crotonimide C, a new glutarimide alkaloid from the Kenyan Croton alienus. Planta Med. 2013 Dec;79(18):1762-6. doi: 10.1055/s-0033-1351044. Epub 2013 Dec 19. doi: 10.3762/bjoc.7.175. Epub 2011 Nov 7.
3: Silva LL, Joussef AC. Synthesis of N-[(3S)-2,6-dioxo-1-(2-phenylethyl)-3-piperidinyl]-(2S)-2-methylbutanamide ((-)-julocrotine). J Nat Prod. 2011 Jun 24;74(6):1531-4. doi: 10.1021/np200234e. Epub 2011 May 5. doi: 10.1007/s00436-010-1973-0. Epub 2010 Jul 27.
合成参考文献
参考文献:10.1002/qua.21355
摘要:Moreira RYO, Brasil DSB, Alves CN, Guilhon GMSP, Santos LS, Arruda MSP, Müller AH, Barbosa PS, Abreu AS, Silva EO, Rumjanek VM, Souza J, da Silva ABF, Santos RHDA. Crystal structure and theoretical calculations of Julocrotine, a natural product with antileishmanial activity. Int J of Quantum Chemistry. 2007 Oct 03;108(3):513–20. doi: 10.1002/qua.21355.
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