CAS: 3140-92-9; 2,4-Dibromothiophene

该化合物是一种含有分子式C4H2BR2S的溴化杂交化合物.它作为有机合成的多用途中间体,特别是在为制药,农用化学品和材料科学准备基于硫苯衍生物的过程中.在2和4位位置上存在溴原子,这增强了其在交叉反应中的反应性能,如铃木或静态结合,能够有效发挥作用.它的高度纯度和稳定性使它适合于精确的合成应用.此外,2,4-二溴硫苯对于合成聚合物和电子材料的开发很有价值,因为它能够对硫苯基纸条进行电子特性的调节.

结构式图片

欧盟法规

ECHA物质C&L通报

上下游产品

CAS号3141-24-0 2,3,5-三溴噻吩 | CAS号3141-27-3 2,5-二溴噻吩 | CAS号5713-61-1 2-噻吩基溴化镁 | CAS号3140-93-0 2,3-二溴噻吩 | CAS号118833-77-5 3,5-dibromo-[2]... | CAS号7732-18-5 水 | CAS号925-90-6 乙基溴化镁 | CAS号3172-56-3 3,3'-双噻吩 | CAS号105124-99-0 4-bromo-2-thiop... | CAS号105124-97-8 2,4-di(thiophen... | CAS号23688-07-5 3,5-二溴-2-噻吩羧醛 | CAS号690266-86-5 4-bromo-2-(trim... | CAS号1108749-40-1 2,4-bis[2-(trim... | CAS号4526-07-2 1,4-双(三甲硅基)-1,3-丁二炔 | CAS号7311-68-4 3,5-二溴噻吩-2-甲酸 | CAS号125143-53-5 3,3',5,5'-四溴-2,... | CAS号18791-75-8 4-溴-2-噻吩甲醛

合成工艺路线路线简述

    专利信息


    专利号:US-9045462-B2
    优先权日:2012-08-17
    标 题 :Synthesis of an antiviral compound
    发明人:EVANS JARED WAYNE; FUJIMORI SHINJI; HUYNH GRACE M; LIU QI; TERESK MARTIN GERALD
    权利人:GILEAD SCIENCES INC
    摘要:The present disclosure provides processes for the preparation of a compound of Formula I: n nwhich is useful as an antiviral agent. The disclosure also provides compounds that are synthetic intermediates to compounds of formula.

    专利号:US-8927741-B2
    优先权日:2012-08-17
    标 题 :Synthesis of an antiviral compound
    发明人:WATKINS WILLIAM JOHN; LIU QI
    权利人:GILEAD SCIENCES INC
    摘要:The present disclosure provides a processes for the preparation of a compound of Formula I: n nwhich is useful as an antiviral agent. The disclosure also provides compounds that are synthetic intermediates to compounds of Formula I.

    专利号:US-8507538-B2
    优先权日:2009-11-13
    标 题:Selective heterocyclic sphingosine 1 phosphate receptor modulators
    发明人:BOEHM MARCUS F; MARTINBOROUGH ESTHER; BRAHMACHARY ENUGURTHI; MOORJANI MANISHA; TAMIYA JUNKO; HUANG LIMING; YEAGER ADAM RICHARD
    权利人:BOEHM MARCUS F; MARTINBOROUGH ESTHER; BRAHMACHARY ENUGURTHI; MOORJANI MANISHA; TAMIYA JUNKO; HUANG LIMING; YEAGER ADAM RICHARD; RECEPTOS INC
    摘要:Compounds that selectively modulate the sphingosine 1 phosphate receptor are provided including compounds which modulate subtype 1 of the S1P receptor. Methods of chiral synthesis of such compounds is provided. Uses, methods of treatment or prevention and methods of preparing inventive compositions including inventive compounds are provided in connection with the treatment or prevention of diseases, malconditions, and disorders for which modulation of the sphingosine 1 phosphate receptor is medically indicated.

    专利号:US-8759544-B2
    优先权日:2012-08-17
    标 题:Synthesis of an antiviral compound

    专利号:US-9481659-B2
    优先权日:2011-05-13
    标 题 :Selective heterocyclic sphingosine 1 phosphate receptor modulators
    发明人:BOEHM MARCUS F; MARTINBOROUGH ESTHER; BRAHMACHARY ENUGURTHI; MOORJANI MANISHA; TAMIYA JUNKO; HUANG LIMING; YEAGER ADAM RICHARD
    权利人:BOEHM MARCUS F; MARTINBOROUGH ESTHER; BRAHMACHARY ENUGURTHI; MOORJANI MANISHA; TAMIYA JUNKO; HUANG LIMING; YEAGER ADAM RICHARD; CELGENE INT II SÀRL
    摘要:Compounds that selectively modulate the sphingosine 1 phosphate receptor are provided including compounds which modulate subtype 1 of the S1P receptor. Methods of chiral synthesis of such compounds is provided. Uses, methods of treatment or prevention and methods of preparing inventive compositions including inventive compounds are provided in connection with the treatment or prevention of diseases, malconditions, and disorders for which modulation of the sphingosine 1 phosphate receptor is medically indicated.

    专利号:US-2014051866-A1
    优先权日:2012-08-17
    标题 :Synthesis of an antiviral compound
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    合成参考文献


    摘要:Li, Y.; Xie, W.; Jiang, X., Science of Synthesis Knowledge Updates, (2016) 2, 8.
    摘要:Schatz, J.; Seler, M., Science of Synthesis Knowledge Updates, (2011) 2, 403.
    摘要:Xia, J.-B.; You, S.-L., Science of Synthesis: Catalytic Transformations via CH Activation, (2015) 2, 117.
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