专利号:US-6306179-B1 优先权日:1997-10-22 标题:Method for the synthesis of 2-hydroxyalkyl-para-phenylenediamines, new 2-hydroxyalkyl-para-phenylenediamines, their use for oxidation dyeing, dyeing compositions and methods of dyeing 发明人:GENET ALAIN; LAGRANGE ALAIN 权利人:OREAL 摘要:The present invention relates to a new method for the synthesis of 2-hydroxyalkyl-para-phenylenediamines which are substituted or unsubstituted at the 5-position of the benzene ring, new 2-hydroxyalkyl-para-phenylenediamines which are substituted or unsubstituted at the 5-position of the benzene ring, their use for the oxidation dyeing of keratinous fibers, the dyeing compositions containing them, as well as the methods of dyeing using them.
专利号:US-6118008-A 优先权日:1996-05-03 标 题:Diamino pyrazols, their synthesis, keratin fibre dyeing compositions containing them, keratin fibre dyeing methods 发明人:MALLE GERARD; VIDAL LAURENT; BURANDE AGNES; MAUBRU MIREILLE 权利人:OREAL 摘要:The invention discloses new 5-substituted 3,4-diamino pyrazols, their methods of preparation, compositions for keratin fiber oxidation dyeing containing them as an oxidizing base, and the dyeing methods using same.
专利号:US-8012220-B2 优先权日:2006-04-13 标题 :Specific monocationic monochromophoric compounds of hydrazone type comprising a 2-, 4-pyridinium or 2-, 4-quinolinium unit, synthesis thereof, dye compositions containing them, and method for dyeing keratin fibres 发明人:DAVID HERVE; MURGUET NADEGE; GREAVES ANDREW 权利人:OREAL 摘要:The present disclosure relates to monocationic monochromophoric compounds of formula (I) and (II) and dyeing compositions and multicompartment devices comprising monocationic monochromophoric compounds of formula (I) and (II). The disclosure also relates to methods for preparing monocationic monochromophoric compounds of formula (I) and (II), and also to methods for dyeing comprising applying monocationic monochromophoric compounds of formula (I) and (II) to keratin fibers.
专利号:US-7723498-B2 优先权日:2004-06-04 标题:Directed evolution of recombinant monooxygenase nucleic acids and related polypeptides and methods of use 发明人:WOOD THOMAS K; VARDAR GONUL 权利人:UNIV CONNECTICUT 摘要:The present invention relates to novel monooxygenase nucleic acids and polypeptides created using mutagenesis, DNA shuffling, or both, in a single iteration or multiple iterations, and methods for their creation and use. The monooxygenase enzymes of the present disclosure have particular utility as biocatalysts in industrial chemical redox reactions, such as the oxidation of aromatic hydrocarbons, for example, toluene, benzene, or nitrobenzene, into industrially desirable products. The systems and processes of the present invention are especially useful for the coupled synthesis and recovery of catechols, methylcatechols, resorcinols, methylresorcinols, hydroquinones, methylhydroquinones, hydroxybenzenes, cresols, nitrobenzenes, and nitrohydroxyquinones.
专利号:WO-2024132278-A1 优先权日:2022-12-20 标题:Synthesis, pharmacology and use of new water-soluble and selective fms-like tyrosine kinase 3 (flt3) inhibitors 发明人:MAHBOOBI SAVOSH; WIRTH LUKAS; PONGARTZ HERWIG; SELLMER ANDREAS 权利人:UNIV REGENSBURG 摘要:The present application relates to compounds of formula (I) for inhibiting FLT3. The present application further relates to a composition, preferably pharmaceutical composition, comprising a compound or a pharmaceutically acceptable salt thereof and comprising a pharmaceutically acceptable excipient and/or carrier. The present application also relates to a compound or composition for use in medicine. The present application also relates to a compound or composition for use in a method of preventing or treating cancer, preferably blood cancer, more preferably leukemia, even more preferably acute myeloid leukemia (AML). Furthermore, the present application relates to a method of preparing a compound.
专利号:WO-2008028776-A1 优先权日:2006-09-06 标题 :Agents containing bioquinones and specific emulsifiers 发明人:SCHULZE ZUR WIESCHE ERIK; SCHEUNEMANN VOLKER; POPPE ELISABETH; WELSS THOMAS; GIESEN MELANIE 权利人:HENKEL KGAA; SCHULZE ZUR WIESCHE ERIK; SCHEUNEMANN VOLKER; POPPE ELISABETH; WELSS THOMAS; GIESEN MELANIE 摘要:The invention relates to cosmetic agents, in particular hair treatment agents, containing at least one specific emulsifier and at least one bioquinone. Treating the hair with said agents activates the keratin synthesis of hair keratin that declines with age.
[参考文献]: Martin Vidrnoch, Et Al. Determination Of Selected Synthetic Cannabinoids And Their Metabolites By Micellar Electrokinetic Chromatography--Mass Spectrometry Employing Perfluoroheptanoic Acid-Based Micellar Phase. Talanta. 2016 Apr 1:150:568-76. [参考文献]: Nenad Manevski, Et Al. Albumin Stimulates The Activity Of The Human Udp-Glucuronosyltransferases 1A7, 1A8, 1A10, 2A1 And 2B15, But The Effects Are Enzyme And Substrate Dependent. Plos One. 2013;8(1):E54767. [参考文献]: Yoshimitsu Yamazaki, Et Al. Inhibitory Effect Of Hydroxyindoles And Their Analogues On Human Melanoma Tyrosinase. Z Naturforsch C J Biosci. 2010 Jan-Feb;65(1-2):49-54.
合成参考文献
摘要:Joule, J. A., Science of Synthesis Knowledge Updates, (2010) 2, 293. 摘要:S13 | EUCOSMETICS | Combined Inventory of Ingredients Employed in Cosmetic Products (2000) and Revised Inventory (2006) | DOI:10.5281/zenodo.2624118 摘要:International Journal of Toxicology 33(Suppl. 3):24-35, 2014