CAS: 22246-18-0; 7-Hydroxy-3,4-Dihydroquinolin-2(1H)-One

相似化合物

30389-33-4 22246-17-9 54197-66-9

上下游产品

CAS号21261-76-7 3-Chloro-N-(3-m... | CAS号50297-40-0 N-(3-羟基苯基)-3-氯P... | CAS号536-90-3 间氨基苯甲醚 | CAS号625-36-5 3-氯丙酰氯 | CAS号591-27-5 间氨基苯酚 | CAS号7403-75-0 N-(4-hydroxy-2-... | CAS号22246-17-9 7-甲氧基-3,4-二氢喹啉-... | CAS号103986-96-5 3-(4-methoxy-2-... | CAS号58196-33-1 7-羟基-1,2,3,4-四氢喹啉 | CAS号129722-12-9 阿立哌唑 | CAS号129722-34-5 7-(4-溴丁氧基)-3,4-... | CAS号120004-79-7 7-(4-氯丁氧基)-3,4-... | CAS号1194459-28-3 6-Bromo-7-hydro... | CAS号71130-68-2 1-乙基-1,2,3,4-四氢... | CAS号952308-47-3 7-(4-iodobutoxy... | CAS号58022-96-1 7-(3-chloroprop...

Methyl 3-(4-Hydroxy-2-Nitrophenyl)Prop-2-Enoate置于氢气,甲烷体系中,用 甲醇 用作溶剂,化学反应 24.0H,以360 Mg的收率获得3,4-二氢-7-羟基-2(1H)-喹啉酮
参考文献:Method For Producing A Cross-Coupling Product Of A Benzenoid Diazonium Salt
标题:Method For Producing A Cross-Coupling Product Of A Benzenoid Diazonium Salt
摘要:该发明涉及一种根据通式(I)制备苯并重氮盐的交叉偶联产物的方法,其中基团r1,R2,R3,R4和r5代表氢,卤素,烷基,烯基,芳基,烷氧基,芳氧基,硝基,氰基,羟基,乙酰基和/或重氮基,X代表bf4,Cl,F,So3Ch3,Co2Ch3,Pf6,Clo2Ch3或cio4,包括以下步骤:(A)提供苯并酰胺,除了重氮功能外,具有通式(I)中苯并重氮盐相同的取代基r1,R2,R3,R4和r5,并水解裂解酰胺形成胺或提供相应的胺,(B)用亚硝酸盐重氮得到或提供的胺,(C)随后在催化剂存在下将苯并重氮盐与偶联配体反应形成交叉偶联产物,其中偶联配体由通式(II)表示,R6,R7和r8相同或不同,代表氢,羧基烷基,羧基芳基,烷基,芳基,烷氧基,芳氧基,其中基团可以包含si,N,S,O和/或卤素原子,或r6和r7与双键形成芳香环,可提供r8和一个到四个进一步取代基,独立于彼此,选自包括直链或支链(C1-C6)烷基,(C3-C7)环烷基,直链或支链(C1-C6)烯基,直链或支链(C1-C6)烷氧基,卤素,羟基,氨基,二(C1-C6)烷基氨基,硝基,乙酰基,氰基,苄基,4-甲氧基苄基,4-硝基苄基,苯基和4-甲氧基苯基,表示y=h,-b(Or)2,-snr3,-znr,-sir3或mg(卤素),至少步骤(B)和(C)在不中间分离中间产物的情况下执行.根据该方法,可以更简单地进行交叉偶联,并且在含有羟基的芳香反应物中无需提供保护基即可获得改进的收率.

专利信息

专利号:US-2007149782-A1
优先权日:2005-12-23
标 题:Methods of preparing a crystalline form of 7-(4-chlorobutoxy)-3,4-dihydro-2(1h)-quinolinone and the use thereof in the synthesis of Aripiprazole
发明人：BRAND MICHAEL; SHOOKRUN MOTY; GRIBUN IRINA; ADIN ITAI; IUSTAIN CARMEN; BRAVERMAN OLEG; UDIS NATALIA; ARAD ODED; KASPI JOSEPH
权利人:BRAND MICHAEL; SHOOKRUN MOTY; GRIBUN IRINA; ADIN ITAI; IUSTAIN CARMEN; BRAVERMAN OLEG; UDIS NATALIA; ARAD ODED; KASPI JOSEPH
摘要:The present invention relates to methods of preparing a highly pure crystalline form of 7-(4-chlorobutoxy)-3,4-dihydro-2(1H)-quinolinone, which is a chemical intermediate useful in the preparation of Aripiprazole thereof in high quality and yield, and provides data that characterizes the crystalline form of 7-(4-chlorobutoxy)-3,4-dihydro-(1H)-quinolinone.

专利号:US-5283336-A
优先权日:1992-09-08
标 题 :Method for preparation of 7-hydroxy-1,2,3,4-tetrahydroquinoline from 1,2,3,4-tetrahydroquinoline
发明人：FIELD GEORGE; HAMMOND PETER R
权利人:US ARMY
摘要:Methods for the efficient preparation of 7-hydroxy-1,2,3,4-tetrahydroquinoline include a first method in which the acylation of m-aminophenol obtains a lactam which is reduced to give the desired quinoline and a second method in which tetrahydroquinoline is nitrated and hydrogenated and then hydrolyzed to obtain the desire quinoline. 7-hydroxy-1,2,3,4-tetrahydroquinoline is used in the efficient synthesis of four lasing dyes of the rhodamine class.

专利号:US-9951088-B2
优先权日:2012-05-09
标题 :D2 receptor modulators and methods of use thereof in the treatment of diseases and disorders
发明人：JONES PHILIP G; LEW ROBERT; SPEAR KERRY L; XIE LINGHONG
权利人:SUNOVION PHARMACEUTICALS INC
摘要:Provided herein are heteroaryl compounds, methods of their synthesis, pharmaceutical compositions comprising the compounds, and methods of their use. In one embodiment, the compounds provided herein are useful for the treatment, prevention, and/or management of various disorders, such as CNS disorders and neurological disorders, including, but not limited to, e.g., psychosis, schizophrenia, depression, movement disorders, and Parkinson's disease.

专利号:WO-2007072476-A2
优先权日:2005-12-23
标题 :Methods of preparing a crystalline form of 7-(4-chlorobutoxy)-3,4-dihydro-2(1h)-quinolinone and the use thereof in the synthesis of aripiprazole

专利号:CN-1513838-A
优先权日:2003-08-08
标题:One-pot synthesis of aripiprazole

专利号:CN-113214150-A
优先权日:2021-04-20
标 题:A kind of synthesis of high-purity aripiprazole and preparation method of hydrate microparticles