专利号:US-2005244935-A1 优先权日:1999-06-25 标题:Corynebacterium glutamicum genes encoding proteins involved in membrane synthesis and membrane transport 发明人:POMPEJUS MARKUS; KROGER BURKHARD; SCHRODER HARTWIG; ZELDER OSKAR; HABERHAUER GREGOR 权利人:BASF AG 摘要:Isolated nucleic acid molecules, designated MCT nucleic acid molecules, which encode novel MCT proteins from Corynebacterium glutamicum are described. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing MCT nucleic acid molecules, and host cells into which the expression vectors have been introduced. The invention still further provides isolated MCT proteins, mutated MCT proteins, fusion proteins, antigenic peptides and methods for the improvement of production of a desired compound from C. glutamicum based on genetic engineering of MCT genes in this organism.
专利号:US-11766412-B2 优先权日:2016-09-29 标 题:Methods of treating or alleviating adenylosuccinatelyase (ADSL) deficiency using spermidine or a pharmaceutically acceptable salt of spermidine 发明人:PAN WUGUANG; ZHU WEI 权利人:GENEHEAL BIOTECHNOLOGY CO LTD 摘要:Provided are compounds reducing SAICAR accumulation, and applications. On the basis of existing protein structure data and small molecule structure data, calculations and analysis are performed using software to screen and obtain compounds capable of effectively interfering with PAICS activity, reducing SAICAR synthesis, and ultimately reducing SAICAR accumulation, in order to achieve the goal of treating or improving ADSL deficiency. A better effect in the treatment or improvement of ADSL deficiency is expected from the joint use of at least two of the described compounds.
专利号:WO-2024160989-A1 优先权日:2023-02-03 标题 :Herbicide resistant plants 发明人:DALE RICHARD PAUL; BATCHELOR ANTHEA KARIN; BROCKLEHURST DAVID; DUXBURY ZANE LEWIS; LINNEY EMMA CATHERINE 权利人:SYNGENTA CROP PROTECTION AG 摘要:The present invention relates to plants and parts thereof that have been modified to comprise a BioA and/or BIO3-BIO1 (BioDA) enzyme which confers at least partial resistance to compounds which inhibit the biotin synthesis pathway, such as herbicides, wherein in some cases the enzymes may be overexpressed to confer resistance, or may comprise modifications which confer resistance. The invention further relates to such modified BioA or BIO3-BIO1 enzymes, having modifications which improve resistance to such compounds, as well as polynucleotides and proteins encoding such enzymes. The invention also relates to methods of growing and propagating such plants, improving plant growth and controlling unwanted vegetation using such plants and parts thereof.
专利号:JP-2007526751-A 优先权日:2003-07-10 标 题:Stereoselective synthesis method and enantiomeric enrichment method of β-amino acid
参考文献:10.1080/15216540600746997 摘要:Bhor V, Dev S, Vasanthakumar G, Surolia A. Spectral and kinetic characterization of 7,8-diaminopelargonic acid synthase from Mycobacterium tuberculosis. IUBMB Life (International Union of Biochemistry and Molecular Biology: Life). 2006 Apr 01;58(4):225–33. doi: 10.1080/15216540600746997.