CAS: 1832-53-7; Ethyl Methylphosphonic Acid

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📜O-乙基-S-[2-(二异丙氨基)乙基]甲基硫代磷酸酯置于zr6 Based N-Dimethyl Biphenyldicarboxylate Framework体系中,用 Aq. Buffer 用作溶剂,化学反应 0.79H,反应生成甲基磷酸乙酯
参考文献:使用基于zr 6的金属有机框架有效,便捷和选择性地水解化学战剂vx
标题:使用基于zr 6的金属有机框架有效,便捷和选择性地水解化学战剂vx
摘要:神经毒剂vx是人类已知的最具毒性的化学物质,因此需要强大的解决方案来快速有选择地使其失活.在本文中,我们证明了三种基于zr 6的金属有机骨架(mof),即uio-67,Uio-67-Nh 2和uio-67-N(me)2,是该催化剂的选择性和高活性催化剂vx水解.在n-乙基吗啉的ph 10缓冲溶液中使用uio-67,Uio-67-Nh 2和uio-67-N(me)2,观测到vx中p-s键的选择性水解.另外,Uio-67-N(me)2被发现可催化vx水解,初始半衰期为1.8分钟.该半衰期比迄今为止对vx水解进行测试的唯一其他mof的半衰期短了近3个数量级,可与最佳非酶材料的活性相媲美.利用基于zr的mof的水解在没有ph 10缓冲液(只有水)的情况下也是选择性的,并且容易破坏有毒副产物ea-2192.
Doi:10.1021/acs.Inorgchem.5B01813

专利信息

专利号:US-2015099864-A1
优先权日:2013-10-08
标题:Preparation of organophosphate peptide adducts
发明人：BREWER BOBBY N; LUCAS ERIC A; BURKITT NATHAN T
权利人:BATTELLE MEMORIAL INSTITUTE
摘要:Disclosed are methods for the synthesis of organophosphorus-adducted peptides. Such peptides may be useful as biomarkers of organophosphate exposure, or for the synthesis of antibodies. Also disclosed are peptide adducts including peptide adducts of tabun, and aged adducts.

专利号:WO-2015053980-A1
优先权日:2013-10-08
标 题 :Preparation of organophosphate peptide adducts
发明人：BREWER BOBBY N; LUCAS ERIC A; BURKITT NATHAN T
权利人:BATTELLE MEMORIAL INSTITUTE
摘要:Disclosed are methods for the synthesis of organophosphorus-adducted peptides. Such peptides may be useful as biomarkers of organophosphate exposure, or for the synthesis of antibodies. Also disclosed are peptide adducts including peptide adducts of tabun, and aged adducts.

专利号:US-7252812-B2
优先权日:1998-09-18
标 题:High-yield method of endohedrally encapsulating species inside fluorinated fullerene nanocages
发明人：YAKOBSON BORIS I; AVRAMOV PAVEL V; MARGRAVE LEGAL REPRESENTATIVE; MICKELSON EDWARD T; HAUGE ROBERT H; BOUL PETER J; HUFFMAN CHAD B; SMALLEY RICHARD E
权利人:YAKOBSON BORIS I; AVRAMOV PAVEL V; MARGRAVE LEGAL REPRESENTATIVE; MICKELSON EDWARD T; HAUGE ROBERT H; BOUL PETER J; HUFFMAN CHAD B; SMALLEY RICHARD E
摘要:This invention is directed to the fluorination (or derivatization with alternative chemical species) of fullerene carbon nanocages as an efficient way to (a) facilitate synthesis of endohedral complexes by a significant reduction or elimination of the barriers for the entry of guest-ions, -atoms or molecules, and (b) to preserve the chemical stability of final product.

专利号:US-8017776-B2
优先权日:2003-07-15
标题 :Methods for synthesis of acyloxyalkyl compounds
发明人：BHAT LAXMINARAYAN; GALLOP MARK A
权利人:XENOPORT INC
摘要:Disclosed herein are methods for synthesizing 1-(acyloxy)-alkyl prodrug derivatives of drugs through oxidation of 1-acyl-alkyl derivatives of drugs under anhydrous reaction conditions. The methods typically proceed stereospecifically, in high yield, do not require the use of activated intermediates and/or toxic compounds and are readily amenable to scale-up.

专利号:WO-2006021326-A1
优先权日:2004-08-27
标题:Process and intermediates for the selective synthesis of fluvastatin
发明人：ZHU GUORONG; GONG HONGQUAN; BECKER STEFAN
权利人:ZHEJIANG HISUN PHARMACEUTICAL; TIEFENBACHER PHARMACHEMIKALIEN; ZHU GUORONG; GONG HONGQUAN; BECKER STEFAN
摘要:The invention relates to process for the selective preparation of 3-hydroxy-6-dialkoxyphosphoryl-5-oxo-hexanoic acid esters, comprising a first step, in which a methylphosphonic acid dialkylester is treated with a base, and a second step, in which the product of the primary reaction is reacted with an optionally 3-protected 3-hydroxy-1,5-pentanoic diacid ester.

专利号:US-6593347-B2
优先权日:1998-10-30
标题 :Nitrosated and nitrosylated nonsteroidal antiinflammatory compounds, compositions and methods of use
发明人：BANDARAGE UPUL K; DONG QING; FANG XINQIN; GARVEY DAVID S; MERCER GREGORY J; RICHARDSON STEWART K; SCHROEDER JOSEPH D; WANG TIANSHENG
权利人:NITROMED INC
摘要:The present invention describes novel nitrosated and/or nitrosylated nonsteroidal antiinflammatory compounds, and novel compositions comprising at least one nitrosated and/or nitrosylated nonsteroidal antiinflammatory compound, and, optionally, at least one compound that donates, transfers or releases nitric oxide, elevates endogenous levels of endothelium-derived relaxing factor, stimulates endogenous synthesis of nitric oxide or is a substrate for nitric oxide synthase. The present invention also provides methods for treating, preventing and/or reducing inflammation, pain, and fever; decreasing or reversing the gastrointestinal, renal and other toxicities resulting from the use of nonsteroidal antiinflammatory drugs; treating and/or preventing gastrointestinal disorders; treating inflammatory disease states and disorders; and treating and/or preventing ophthalmic diseases or disorders.