CAS: 16179-97-8; 2-(Pyridin-2-yl)Acetic Acid Hydrochloride

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CAS号100-70-9 2-氰基吡啶 | CAS号19615-30-6 2-哌啶乙酸盐酸盐 | CAS号1658-42-0 2-吡啶乙酸甲酯 | CAS号150059-62-4 PYRIDIN-2-YL-AC... | CAS号67870-16-0 2-(吡啶-2-基)乙酸钠 | CAS号806619-17-0 N-butyl-2-pyrid... | CAS号85330-44-5 2-(pyridin-2-yl... | CAS号958-58-7 6-BROMO-3-(PYRI...

2-Oxo-3-Pyridin-2-Yl-Propionic Acid置于sodium Perborate体系中,用 水 用作溶剂,化学反应 48.0H,以86%的收率获得2-吡啶乙酸盐酸盐
参考文献:使用过硼酸钠对β-芳基丙酮酸进行氧化脱羰
标题:使用过硼酸钠对β-芳基丙酮酸进行氧化脱羰
摘要:在环境温度下,使用过硼酸钠四水合物(spb)在水溶液中氧化β-芳基-和β-杂芳基丙酮酸,可以得到相应的芳酸,收率很好(68-86%).温和的条件便于制备热不稳定的酸.特别地,该方法已经用于制备不稳定的5-硝基咪唑-2-基乙酸,由于丙酮酸前体的烯醇化,显然不能使用其他试剂获得该不稳定的5-硝基咪唑-2-基乙酸.尝试在酸性溶液中使用次氯酸钙或spb进行脱羰反应会生成2-氯甲基衍生物.作为具有生物学意义的分子的前体所需要的新型5-硝基咪唑-2-基乙酸已经被充分表征并转化为已知的酰胺.该酸与vilsmeier'的反应 试剂产生了烯胺衍生物,而不是预期的vinamidinium盐.这种新颖的反应方式可归因于分子内氢键和非常好的共轭作用.
Doi:10.1016/s0040-4020(98)00518-3

专利信息

专利号:US-8735586-B2
优先权日:2007-06-26
标 题 :Regioselective copper catalyzed synthesis of benzimidazoles and azabenzimidazoles
发明人：ALONSO JORGE; LINDENSCHMIDT ANDREAS; NAZARÉ MARC; URMANN MATTHIAS; HALLAND NIS; RKYEK OMAR
权利人:ALONSO JORGE; LINDENSCHMIDT ANDREAS; NAZARÉ MARC; URMANN MATTHIAS; HALLAND NIS; RKYEK OMAR; SANOFI SA
摘要:The present invention relates to a process for the regioselective synthesis of compounds of the formula I, n nwherein R0; R1; R2; R3; R4; R5; A1; A2; A3; A4, Q and J have the meanings indicated in the claims. The present invention provides a direct copper catalyzed regioselective process to a wide variety of unsymmetrical, multifunctional N-substituted benzimidazoles or azabenzimidazoles of formula I starting from 2-halo-nitroarenes and N-substituted amides.

专利号:EP-2173747-B1
优先权日:2007-06-26
标 题:A regioselective metal catalyzed synthesis of annelated benzimidazoles and azabenzimidazoles
发明人：ALONSO JORGE; LINDENSCHMIDT ANDREAS; NAZARE MARC; R KYEN OMAR; URMANN MATHIAS; HALLAND NIS
权利人:SANOFI SA
摘要:The present invention relates to a process for the regioselective synthesis of compounds of the formula I, wherein R1; R2; R3; R4; J1; J2; J3; J4 and G have the meanings indicated in the claims. The present invention provides a direct metal, e.g. palladium or copper, catalyzed, regioselective process to a wide variety of unsymmetrical, multifunctional N-substituted benzimidazoles or azabenzimidazoles of formula I starting from 2-halo-nitroarenes and N-substituted amides.

专利号:US-7109377-B2
优先权日:1996-10-16
标 题:Synthesis of combinatorial libraries of compounds reminiscent of natural products
发明人：SCHREIBER STUART L; SHAIR MATTHEW D; TAN DEREK S; FOLEY MICHAEL A; STOCKWELL BRENT R
权利人:HARVARD COLLEGE
摘要:The present invention provides complex compounds reminiscent of natural products and libraries thereof, as well as methods for their production. The inventive compounds and libraries of compounds are reminiscent of natural products in that they contain one or more stereocenters, and a high density and diversity of functionality. In general, the inventive libraries are synthesized from diversifiable scaffold structures, which are synthesized from readily available or easily synthesizable template structures. In certain embodiments, the inventive compounds and libraries are generated from diversifiable scaffolds synthesized from a shikimic acid based epoxyol template. In other embodiments, the inventive compounds and libraries are generated from diversifiable scaffolds synthesized from the pyridine-based template isonicotinamide. The present invention also provides a novel ortho-nitrobenzyl photolinker and a method for its synthesis. Furthermore, the present invention provides methods and kits for determining one or more biological activities of members of the inventive libraries. Additionally, the present invention provides pharmaceutical compositions containing one or more library members.

专利号:US-9695147-B2
优先权日:2013-07-25
标题 :Process for the preparation of perampanel
发明人：BUCHLOVIC MARIAN
权利人:TEVA PHARMACEUTICALS INT GMBH
摘要:The present invention provides intermediates useful for the synthesis of Perampanel and processes employing said intermediates for preparing Perampanel. The invention also provides processes for making the intermediates, crystalline forms of the intermediates and the use of the crystalline forms for preparing Perampanel.

专利号:US-8926801-B2
优先权日:2009-01-16
标题 :Methods of electrospray chemical synthesis and device for use therein
发明人：REHMAN ATIQ
权利人:REHMAN ATIQ; CANAM BIORES INC
摘要:The present invention relates to methods of production of chemical bonds and subsequent molecules by electrospray ionization and the design of an electrospray chemical synthesizer, for use in chemical synthesis and expedited organic chemical reactions.

专利号:US-2003082830-A1
优先权日:1996-10-16
标 题:Synthesis of combinatorial libraries of compounds reminiscent of natural products