十八烷腈置于[ru(H)(Bh4)(Co)(Pph3)(3-(Di-Tert-Butylphosphino)-N-((1-Methyl-1H-Imidazol-2 Yl)Methyl)Propylamine)],氢气体系中,用 异丙醇 用作溶剂,化学反应 3.0H,以88%的收率获得十八胺 参考文献:Nnp型夹钳咪唑基膦钌配合物:在温和条件下有效地进行芳香族和脂肪族腈的无碱加氢 标题:Nnp型夹钳咪唑基膦钌配合物:在温和条件下有效地进行芳香族和脂肪族腈的无碱加氢 摘要:已合成并充分表征了一系列七个新型的n Im N H P型钳型咪唑基膦膦钌配合物.使用苯甲腈加氢作为基准测试,确定了[ruhcl(co)(n Im N H P T Bu)]是最具活性的催化剂.凭借其稳定的ru-Bh 4类似物(其中氯化物被bh 4替代),已在温和且无碱的条件下氢化了多种(杂)芳族和脂肪族腈,包括工业上有用的己二腈. Doi:10.1002/chem.201504709
专利号:US-2004242897-A1 优先权日:2002-07-31 标题 :Universal support media for synthesis of oligomeric compounds 发明人:GUZAEV ANDREI P; MANOHARAN MUTHIAH 摘要:Compounds for the synthesis of oligomeric compounds, particularly oligonucleotides and oligonucleotide mimetics, are provided. In addition, methods for functionalizing a support medium with a first monomeric subunit and methods for the synthesis of oligomeric compounds utilizing the novel compounds bound to support media are provided.
专利号:US-6117992-A 优先权日:1996-08-26 标题 :Reagents and process for synthesis of oligonucleotides containing phosphorodithioate internucleoside linkages 发明人:IYER RADHAKRISHNAN P 权利人:HYBRIDON INC 摘要:The invention provides new methods for synthesizing oligonucleotides containing at least one, and preferably all phosphorodithioate internucleoside linkages with less than 5% phosphoromonothioate contamination. This level of purity in the synthesis of phosphorodithoates has previously been very difficult to achieve with all existing methods. The invention further provides phosphorothioamidite nucleoside synthons comprising a sulfur protecting group that is stable under normal oligonucleotide synthesis conditions.
专利号:US-12252397-B2 优先权日:2019-05-02 标题:Process for the synthesis of nanoparticles of transition metal chalcogenides 发明人:MONIKA MONIKA; PODDAR PANKAJ 权利人:COUNCIL SCIENT IND RES 摘要:A process for the synthesis of transition metal chalcogenides (TMC) having formula (I). More particularly, the present work relates to a one pot single phase process for the synthesis of a TMC system having formula (I) by wet chemistry. Formula (I) is represented as Ax-By.
专利号:US-2005130201-A1 优先权日:2003-10-14 标 题 :Splint-assisted enzymatic synthesis of polyribounucleotides 发明人:DERAS MICHAEL; PLEISS JEFFREY A; SCARINGE STEPHEN 权利人:DHARMACON INC 摘要:The present invention comprises methods and compositions for splint-assisted enzymatic synthesis of polyribonucleotides using an RNA polymerizing enzyme. The invention provides ligating ribonucleotides comprising ligating a donor RNA molecule to an acceptor RNA molecule in the presence of RNA ligase and a splint, wherein the donor RNA molecule is comprised of at least one nucleotide and a ligation linker moiety, the acceptor RNA molecule is comprised of at least one nucleotide and a ligation linker moiety and the splint is comprised of a polyribonucleotide. The invention also provides splints for use in splint-assisted enzymatic synthesis using an RNA polymerizing enzyme.
专利号:WO-2004011474-A1 优先权日:2002-07-31 标题:Universal support media for synthesis of oligomeric compounds 发明人:GUZAEV ANDREI P; MANOHARAN MUTHIAH; RAVIKUMAR VASULINGA T; KUMAR RAJU K 权利人:ISIS PHARMACEUTICALS INC; GUZAEV ANDREI P; MANOHARAN MUTHIAH; RAVIKUMAR VASULINGA T; KUMAR RAJU K 摘要:Compounds for the synthesis of oligomeric compounds, particularly oligonucleotide and oligonucleotide mimetics, are provided. In addition, methods for functionalizing a support medium with a first monomeric subunit and methods for the synthesis of oligomeric compounds utilizing the novel compounds bound to support media are provided.
专利号:US-6653468-B1 优先权日:2002-07-31 标 题 :Universal support media for synthesis of oligomeric compounds 发明人:GUZAEV ANDREI P; MANOHARAN MUTHIAH 权利人:ISIS PHARMACEUTICALS INC 摘要:Compounds for the synthesis of oligomeric compounds, particularly oligonucleotides and oligonucleotide mimetics, are provided. In addition, methods for functionalizing a support medium with a first monomeric subunit and methods for the synthesis of oligomeric compounds utilizing the novel compounds bound to support media are provided.
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合成参考文献
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