CAS: 114873-07-3; N-Boc-4-(Trifluoromethyl)-L-Phenylalanine

相似化合物

82317-83-7 114926-38-4 238742-88-6

上下游产品

2-(tert-Butoxycarbonyloxyimino)-2-phenylacetonitrile (S)-4-trifluoromethylphenylalanine tert-butyl dicarbonatedi-tert-butyl dicarbonate 4-bromomethyltrifluoromethylbenzene(S)-2-[(S)-2-(2-{2-[(S)-2-Amino-3-(4-hydroxy-phenyl)-propionylamino]-acetylamino}-acetylamino)-3-(4-trifluoromethyl-phenyl)-propionylamino]-4-methyl-pentanoic acid; hydr°Chloride [(S)-1-Carbamoyl-2-(4-trifluoromethyl-phenyl)-ethyl]-carbamic acid tert-butyl ester tert-butyl (S)-(1-(benzyl(methyl)amino)-1-oxo-3-(4-(trifluoromethyl)phenyl)propan-2-yl)carbamate tert-butyl ester[1-(methoxy-methyl-carbamoyl)-2-(4-trifluoromethyl-phenyl)-ethyl]-carbamic acid tert-butyl ester

📜1-溴-三氟对二甲苯 以60%的收率获得boc-L-4-三氟甲基苯丙氨酸
参考文献:N-Acylamino Acid Amide Compounds And Intermediates For Preparation Thereof
标题:N-Acylamino Acid Amide Compounds And Intermediates For Preparation Thereof
摘要:本发明公开了以下公式(i)所表示的化合物: 其中a代表以下公式(a-1)或以下公式(a-2): B代表以下公式(b): (其中符号如规范中所定义)或其药学上可接受的盐,以及用于制备其的中间体,具有优异的血小板聚集抑制活性和其他性质,并且可用作与纤维蛋白原受体,血栓形成,梗塞等疾病相关的预防或治疗剂.

专利信息

专利号:US-8933018-B2
优先权日:2011-02-07
标题 :Boron containing polybasic bacterial efflux pump inhibitors and therapeutic uses thereof
发明人：GLINKA TOMASZ; HIGUCHI ROBERT; HECKER SCOTT; EASTMAN BRIAN; RODNY OLGA
权利人:GLINKA TOMASZ; HIGUCHI ROBERT; HECKER SCOTT; EASTMAN BRIAN; RODNY OLGA; REMPEX PHARMACEUTICALS INC
摘要:Disclosed herein are polybasic bacterial efflux pump inhibitors containing boronic acid functionality and their methods of synthesis, methods of use, and pharmaceutical compositions. Some embodiments include methods of treating or preventing a bacterial infection by co-administering to a subject infected with bacteria or at risk of infection with bacteria the efflux pump inhibitor with another anti-bacterial agent.