CAS: 104-06-3; N-(4-((2-Carbamothioylhydrazono)Methyl)Phenyl)Acetamide

该化合物是一种化学化合物,属于硫磺氨基甲酸酯的衍生物,是硫代氨基氨基酯的产物,其特点是存在一个气态组(-CHO)和乙酰氨基酸酯,有助于其反应和潜在的生物活动,通常是一种固体,可能具有各种物理特性,如有机溶剂中的溶解性等.硫代二甲基烷基甲基甲酯以其协调化学为名,往往与过渡金属形成复杂体,可增强它们的药理特性.该化合物已经研究过其在药用化学中的潜在应用,特别是其抗微生物和抗癌活动.此外,该化合物还可能表现出抗氧化剂活动和与生物宏观分子相互作用的能力等特性.与许多硫代基甲卡卡基甲苯一样,其具体特征可以因亚基体和合成或使用该化合物的条件而有所不同.

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ammonium thi°Cyanate (E)-2-(4-aminobenzylidene)hydrazinecarbothioamide acetic anhydride para-acetamidobenzaldehydeacetic acid-[4-(thiazol-2-ylhydrazono-methyl)-anilide] H-pyrazol-4-yl)-thiazol-2-ylhydrazonomethyl]-anilide}acetic acid-{4-[4-(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)-thiazol-2-ylhydrazonomethyl]-anilide} N,N'''-bis-(4-acetylamino-benzylidene)-μ-disulfido-dicarboxamidrazoneN,N'''-bis-(4-acetylamino-benzylidene)-μ-disulfido-dicarboxamidrazone 1-(4-acetylamino-benzyl)-thiosemicarbazide

合成工艺路线路线简述

    📜对乙酰氨基苯甲醛置于肼体系中,化学反应 2.0H,反应生成氨硫脲
    参考文献:Preparation Of P-Acetaminobenzaldehyde Thiosemicarbazone
    标题:Preparation Of P-Acetaminobenzaldehyde Thiosemicarbazone
    摘要:
    Doi:10.1021/ja01101A504

    专利信息


    专利号:US-5157143-A
    优先权日:1988-05-11
    标题 :Diastereoselective process for the preparation of intermediates useful for the synthesis of peptide derivatives
    发明人:PELLACINI FRANCO; CHIARINO DARIO; CARENZI ANGELO
    权利人:ZAMBON SPA
    摘要:A diastereoselective process for the preparation of compounds of formula ##STR1## (wherein R and R 1 have the meanings reported in the specification and the asterisks show the asymmetric carbon atoms) starting from the corresponding N-protected 2-amino-3-aryl-propan-1-ol is described. n The compounds of formula I are intermediates useful for the synthesis of pharmacologically active peptides.

    专利号:US-4902790-A
    优先权日:1985-10-10
    标 题 :Novel process for the synthesis of amikacin
    发明人:MANGIA ALBERTO; GIOBBIO VICENZO; ORNATO GIORGIO
    权利人:PIERREL SPA
    摘要:A novel process for the synthesis of amikacin starting from kanamycin A protected at the positions 3 and 6' is described comprising the reaction of kanamycin A with a salt of a bivalent metal cation selected from zinc, nickel, iron, cobalt, manganese, copper and cadmium in the presence of water as the solvent or co-solvent followed by the in situ reaction of the resulting complex with a reactive derivative of L-amino-2-hydroxy-butyric acid, removal of the metal cation of the protecting groups and purification of the thus obtained raw product. The acylation under these conditions is extremely selective.

    专利号:US-6191290-B1
    优先权日:1999-02-24
    标 题 :Taxane derivatives for targeted therapy of cancer
    发明人:SAFAVY AHMAD
    权利人:UAB RESEARCH FOUNDATION
    摘要:The present invention describes for the first time the design and synthesis of a soluble tumor-directed paclitaxel prodrug which may establish a new mode of utilization of the taxane class of anticancer agents in cancer therapy.

    专利号:US-9890126-B2
    优先权日:2012-04-24
    标 题:Synthesis of novel inhibitors of isoprenoid biosynthesis (ISPF)
    发明人:HAGEN TIMOTHY J; ZHANG ZHENG; LAZOWSKI ZACHARY; CLARE MICHAEL; BEGLEY DARREN W
    权利人:UNIV NORTHERN ILLINOIS BOARD OF TRUSTEES; BERYLLIUM DISCOVERY CORP
    摘要:Antibacterial and antimalarial IspF inhibitor compounds and compositions are described. Methods include administering described compounds and compositions to treat bacterial or parasitic infections and to inhibit parasite or bacterial growth.

    专利号:US-2022009967-A1
    优先权日:2020-07-13
    标题 :Isolation and Semi-Synthesis of Rufomycin Analogs
    发明人:FRANZBLAU SCOTT G
    权利人:UNIV ILLINOIS
    摘要:Provided herein are compounds having a structure according to formula I, pharmaceutical compositions thereof, and methods of treating a bacterial infection thereof.

    专利号:WO-2024250607-A1
    优先权日:2023-06-05
    标 题:Chemically modified cytidine triphosphate and preparation method therefor and use thereof
    发明人:MEI HUI; DAI ZIWEN; WEN JUNLIN; ZOU YING
    权利人:SHENZHEN INST OF ADV TECH CAS
    摘要:The present invention provides a chemically modified cytidine triphosphate and a preparation method therefor and a use thereof. According to the present invention, by using a chemical synthesis means, chemically modified cytidine and chemically modified cytidine triphosphate are synthesized, and natural cytidine triphosphate in an mRNA is simply replaced with the chemically modified cytidine triphosphate or is replaced with the combination of the chemically modified cytidine triphosphate and N1-methylpseudouridine triphosphate, so as to enhance the translation efficiency and stability of a target mRNA, reduce immunogenicity, and provide a supplement and new option for mRNA modification technology.

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    📌 第三方产品分析报告

    ✅ COA系统入驻 | 共享模式

    主要参考文献


    1: Khairullah AR, Moses IB, Kusala MKJ, Tyasningsih W, Ayuti SR, Rantam FA, Fauziah I, Silaen OSM, Puspitasari Y, Aryaloka S, Raharjo HM, Hasib A, Yanestria SM, Nurhidayah N. Unveiling insights into bovine tuberculosis: A comprehensive review. Open Vet J. 2024 Jun;14(6):1330-1344. doi: 10.5455/OVJ.2024.v14.i6.2. Epub 2024 Jun 30.
    2: Jowsey WJ, Cook GM, McNeil MB. Antibiotic resistance in Mycobacterium tuberculosis alters tolerance to cell wall-targeting inhibitors. JAC Antimicrob Resist. 2024 Jun 4;6(3):dlae086. doi: 10.1093/jacamr/dlae086.
    3: Singh V, Grzegorzewicz AE, Fienberg S, Müller R, Khonde LP, Sanz O, Alfonso S, Urones B, Drewes G, Bantscheff M, Ghidelli-Disse S, Ioerger TR, Angala B, Liu J, Lee RE, Sacchettini JC, Krieger IV, Jackson M, Chibale K, Ghorpade SR. 1,3-Diarylpyrazolyl-acylsulfonamides Target HadAB/BC Complex in Mycobacterium tuberculosis. ACS Infect Dis. 2022 Nov 11;8(11):2315-2326. doi: 10.1021/acsinfecdis.2c00392. Epub 2022 Nov 3.

    合成参考文献


    摘要:Kayali R, Cöplü N, Ceyhan I, Ocak F, Citil BE, Esen B. [The rates of resistance to second-line drugs in multidrug resistant Mycobacterium tuberculosis strains]. Mikrobiyol Bul. 2006 Jan;40(1-2):1–7.
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