CAS: 103068-40-2; 2-Fluorobenzene-1,3-Diol

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上下游产品

CAS号447462-87-5 2-氟-3-甲氧基苯酚 | CAS号195136-68-6 2-氟-1,3-二甲氧基苯 | CAS号108-46-3 间苯二酚 | CAS号771-69-7 2,3,4-三氟硝基苯 | CAS号155020-44-3 2,4-二甲氧基-3-氟硝基苯 | CAS号195136-66-4 3-氟-2,4-二甲氧基苯胺

3-氟-2,4-二甲氧基苯胺置于盐酸,三溴化硼,Sodium Nitrite体系中,用 二氯甲烷,水 用作溶剂,化学反应 2.25H,反应生成2-氟-1,3-苯二酚
参考文献:绿色小单孢菌唾液酸酶催化水解的去糖基化会限制周转率:Michaelis 复合物的构象意义
标题:绿色小单孢菌唾液酸酶催化水解的去糖基化会限制周转率:Michaelis 复合物的构象意义
摘要:基于核心结构 7-(5-Acetamido-3,5-Dideoxy-D-Glycero-α-D-Galacto-Non-2-Ulopyranosylonic Acid)-(2->6) 的一组七种同位素取代的唾液酸苷天然底物类似物)-β-D-吡喃半乳糖氧基)-8-氟-4-甲基香豆素 (1,Neu5Acα2,6Galβfmu) 已被合成并用于探测 M. Viridifaciens 唾液酸酶转换的限速步骤.环氧 ((18)V),离去基团氧 ((18)V),异头碳 ((13)V),C3-碳 ((13) V),C3-R 氘 ((D)V(R)),C3-S 氘 ((D)V(S)) 和 C3-双氘 ((D)(2)V) 为 0.986 +/-0.003,1.003分别为 +/-0.005,1.021 +/-0.006,1.001 +/-0.008,1.029 +/-0.007,0.891 +/-0.008 和 0.890
Doi:10.1021/ja109199P

专利信息

专利号:US-6229055-B1
优先权日:1996-04-12
标题 :Synthesis of fluorinated xanthene derivatives
发明人：KLAUBERT DIETER H; GEE KYLE R
权利人:MOLECULAR PROBES INC
摘要:Facile syntheses for fluorinated resorcinol and aminophenol derivatives are provided that yield isomer-free products in good yield. These novel methods use generally available precursors and standard laboratory reagents and equipment to reproducibly produce these synthetically useful reagents in relatively large quantities. The resulting fluorinated resorcinols and aniinophenols possess utility in the preparation of fluorinated fluorescein and rhodol dyes.

专利号:US-9045507-B2
优先权日:2005-07-27
标题 :Coumarin-based amino acids for use in enzyme activity and substrate specificity assays
发明人：BARRIOS AMY M; MITRA SAYANTAN
权利人:BARRIOS AMY M; MITRA SAYANTAN; UNIV SOUTHERN CALIFORNIA
摘要:The design, synthesis, and utilization of a novel coumarin-based amino acid and its fluorinated derivatives for use in enzyme activity and substrate specificity assays are described. The synthesis is both facile and high-yielding and allows for the production of a highly fluorescent phosphorylated amino acid that can be incorporated into peptides using standard SPPS techniques. The resultant substrates are efficiently hydrolyzed by PTPs and exhibit a large increase in fluorescence upon hydrolysis. Fluorinated CAP derivatives have utility as fluorogenic enzyme substrates. CAP and its derivatives can be incorporated into combinatorial peptide libraries for assaying enzyme substrate specificities.