CAS: 102-46-5; 4-(Chloromethyl)-1,2-Dimethylbenzene

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CAS号6966-10-5 3,4-二甲基苯甲醇 | CAS号50-00-0 甲醛 | CAS号95-47-6 邻二甲苯 | CAS号123-63-7 三聚乙醛 | CAS号38404-42-1 3,4-二甲基苯甲酸甲酯 | CAS号619-04-5 3,4-二甲基苯甲酸 | CAS号107-30-2 氯甲基甲醚 | CAS号583-71-1 3,4-二甲基溴苯 | CAS号110-88-3 三聚甲醛 | CAS号95-63-6 1,2,4-三甲苯 | CAS号103323-56-4 4-(2-bromoethyl... | CAS号5973-71-7 3,4-二甲基苯甲醛 | CAS号34101-86-5 1,2-双(3,4-二甲苯基)乙烷 | CAS号3020-06-2 2-(3,4-二甲基苯基)乙腈 | CAS号289902-88-1 2-(3,4-dimethyl... | CAS号6966-10-5 3,4-二甲基苯甲醇 | CAS号25173-76-6 3-(3,4-二甲基苯基)丙酸 | CAS号142332-70-5 3-(3,4-Dimethyl... | CAS号17283-14-6 2-(3,4-二甲基苯基)乙胺 | CAS号70759-03-4 1-[(3,4-dimethy...

📜3,4-二甲基苯甲酸甲酯置于吡啶,Lithium Aluminium Tetrahydride,氯化亚砜体系中,用 乙醚,苯 用作溶剂,化学反应 23.0H,反应生成3,4-二甲基氯苄
参考文献:Aromatische Spirane,20. Mitt.: Darstellung Von Dimethylsubstituierten 2-Carboxymethyl-Indan-1-Onen Und Benzylchloriden Als Synthone Fr Synthesen Von Di-Bis Tetramethylierten 2,2-Spirobiindandionen
标题:Aromatische Spirane,20. Mitt.: Darstellung Von Dimethylsubstituierten 2-Carboxymethyl-Indan-1-Onen Und Benzylchloriden Als Synthone Fr Synthesen Von Di-Bis Tetramethylierten 2,2-Spirobiindandionen
摘要:The Isomeric Dimethyl Methylbenzoates 5,Obtained From The Bromides Via Grignard Reactions With Dimethylcarbonate,Were Reduced With Lialh4 To The Hydroxymethyl Derivatives 6. The Latter Were Then Transformed Both To The Benzylchlorides 7 (With Socl2) And To The Aldehydes 8 (With Pyridinium Chlorochromate). Knoevenagel-Doebner Reaction Of 8 Afforded The Acrylic Acids 9 Which (After Hydrogenation To 11) Were Cyclized To The Desired Indanones 12 With Polyphosphoric Acid. On The Other Hand,12C And 12E Were Prepared From Dimethyl 3-Chloropropiophenone (14) By Warming With Sulfuric Acid. After Nah-Catalyzed Reaction With Dimethylcarbonate,The Indanones 12 Gave The Ketoesters 15 Which Then Could Be Hydrogenated To The Indanes 16. All Reactions Proceeded With Satisfactory To Excellent Yields (60-90%).
Doi:10.1007/bf00807400

专利信息

专利号:US-4536599-A
优先权日:1978-08-22
标题:Synthesis of amine derivatives
发明人：MASUKO FUJIO; KATSURA TADASHI
权利人:SUMITOMO CHEMICAL CO
摘要:An amine of the formula, ##STR1## wherein R 1 , R 2 , R 3 , R 4 and R 5 are each hydrogen, alkyl or the like and n is 1, 2 or 3, including α-phenyl-β-(p-tolyl)-ethylamine, which is useful as an optically resolving agent, an intermediate of medicines and the like, is effectively produced by a novel process comprising hydrolysis of the corresponding nitrile of the formula, ##STR2## wherein R 1 , R 2 , R 3 , R 4 , R 5 and n are the same as above, followed by alkali-decomposition of the resulting amide of the formula, ##STR3## wherein R 1 , R 2 , R 3 , R 4 , R 5 and n are the same as above. An amide including the above one is effectively produced by hydrolysis of the corresponding nitrile in the presence of a base and hydrogen peroxide using an organic quaternary ammonium salt and/or a tertiary amine as a catalyst.

专利号:US-4425354-A
优先权日:1977-08-26
标题:Imidazole derivatives and salts thereof, their synthesis, and intermediates, and pharmaceutical formulations
发明人：THOROGOOD PETER B
权利人:BURROUGHS WELLCOME CO
摘要:1-Substituted-imidazoles of the formula: (I) in which A is selected from the group consisting of straight or branched, saturated or unsaturated, acyclic hydrocarbon radicals of from 1 to 3 carbon atoms and R is wherein n is an integer which is at least 1, and the or each Q substituent, which when n is greater than 1 may be the same or different, is selected from a saturated alkyl group of from 1 to 4 carbon atoms or an unsaturated alkyl group of from 2 to 4 carbon atoms, with the proviso that when A is unsaturated Q may also be selected from alkoxy of from 1 to 4 carbon atoms; halo; trihalomethyl; hydroxy; carboxyl; a salt of such a carboxyl group; carboalkyloxy; carboaryloxy; carboarylalkyloxy; -NR6R7 or -CONR6R7; in which R6 and R7 may be the same or different and are hydrogen or alkyl of from 1 to 4 carbon atoms; the 1-substituted-imidazole being the free base or an acid addition salt thereof. Methods of preparing the 1-substituted-imidazoles are also provided. The imidazoles have pharmacological properties that make them of use in the treatment of thromboembolic disorders, shock and angina pectoris.

专利号:EP-1836163-B1
优先权日:2004-12-23
标题 :Pyrrolidine derivatives for the treatment of a disease depending on the activity of renin
发明人：BREITENSTEIN WERNER; COTTENS SYLVAIN; EHRHARDT CLAUS; JACOBY EDGAR; LORTHIOIS EDWIGE LILIANE JEANNE; MAIBAUM JUERGEN KLAUS; OSTERMANN NILS; SELLNER HOLGER; SIMIC OLIVER
权利人:NOVARTIS AG
摘要:Novel 3-mono-, 3,4-di- and 3,4,4,-tri-substituted pyrrolidine compounds, these compounds for use in the diagnostic and therapeutic treatment of a warm-blooded animal, especially for the treatment of a disease (=disorder) that depends on inappropriate activity of renin; the use of a compound of that class for the preparation of a pharmaceutical formulation for the treatment of a disease that depends on inappropriate activity of renin; the use of a compound of that class in the treatment of a disease that depends on inappropriate activity of renin; pharmaceutical formulations comprising a said substituted pyrrolidine compound, and/or a method of treatment comprising administering a said substituted pyrrolidine compound, a method for the manufacture of said substituted pyrrolidine compounds, and novel intermediates and partial steps for their synthesis are described. The substituted pyrrolidine compounds are especially of the formula I wherein the substituents are as described in the specification.

专利号:US-3993690-A
优先权日:1969-03-25
标题:Method of obtaining aromatic tri-or-tetracarboxylic acids
发明人：SUVOROV BORIS VIKTOROVICH; SEMBAEV DAUREN KHAMITOVICH; KOLODINA IVETTA SERGEEVNA; STEPANOVA LIDIA ANATOLIEVNA
权利人:SUVOROV BORIS VIKTOROVICH; SEMBAEV DAUREN KHAMITOVICH; KOLODINA IVETTA SERGEEVNA; STEPANOVA LIDIA ANATOLIEVNA
摘要:A method of obtaining aromatic tri- or tetracarboxylic acids characterized in that tri- or tetraalkylbenzenes or the derivatives thereof with a heteroatom in the side chain, are oxidized by oxygen or an oxygen-containing gas in the vapor phase in the presence of ammonia and water vapor at a molar ratio of the parent alkylbenzenes, oxygen or oxygen-containing gas, ammonia and water vapor equal to 1:2-100:5-40:30-100, respectively, on catalysts comprising vanadium oxides modified by the oxides of tin, titanium, bismuth or molybdenum at a molar ratio of vanadium oxides to the modifying oxides equal to 1:0.5-8 and a temperature of from 350° to 440° C, whereupon the resulting nitriles, imides, cyanimides or the mixtures thereof are subjected to acid or alkaline hydrolysis by 2-10 per cent aqueous solutions of acids or alkalis at a temperature of from 60° to 100° C. n Aromatic tri- or tetracarboxylic acids obtained by the herein-disclosed technique feature a high degree of purity and are applicable as intermediate products of organic synthesis, in particular, as parent substances for polymeric materials.

专利号:US-8916705-B2
优先权日:2011-10-14
标 题:Procaspase-activating compounds and compositions
发明人：HERGENROTHER PAUL J
权利人:UNIV ILLINOIS; TRUSTEES OF THE UNIVERSITY OF ILLILNOIS BOARD OF
摘要:The invention provides compounds and compositions useful for the modulation of certain enzymes. The compounds and compositions can induce of cell death, particularly cancer cell death. The invention also provides methods for the synthesis and use of the compounds and compositions, including the use of compounds and compositions in therapy for the treatment of cancer and selective induction of apoptosis in cells.

专利号:EP-0008532-A1
优先权日:1978-08-22
标 题 :Synthesis of amines