CAS: 95928-49-7; Ethyl 2-Hydroxypyrimidine-5-Carboxylate

该化合物是一种化学化合物,其特点是其火水环结构,这是一个六人组成的芳香环,含有1号位置和3号位置的两个氮原子. 该化合物具有2号位置的氢氧基组和5号位置的乙酯组,有助于有机溶剂中的溶解性.它通常是白色到白色的固体,其分子结构允许药物和农用化学物的潜在应用,因为它有能力作为较复杂的分子的建筑块. 氢氧和木箱功能组的存在表明,它可能参与氢的结合,影响其再活性以及与其他化合物的相互作用.此外,其合成和特征分析对有机化学具有兴趣,特别是在发展与生物活动的化合物方面.与许多化学物质一样,应参考安全数据,以确保妥善处理和使用.

结构式图片

相似化合物

91978-81-3 166757-62-6 6214-64-8

物理性质

MSDS等安全信息

欧盟法规

C&L通报

上下游产品

ethyl 2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate ethyl 3-ethoxypropionate (Z)-ethyl-2-(ethoxymethyl)-3-methoxyacrylate Ethyl (2E)-2-(ethoxymethyl)-3-methoxyacrylate ethyl 2-chloropyrimidine-5-carboxylate 2-aminopyrimidine-5-carboxylic acid ethyl ester ethyl 2-[N-(3,5-di-tert-butylphenyl)amino] pyrimidine-5-carboxylate ethyl 2-[N-(3,5-di-tert-butylphenyl)-N-methylamino] pyrimidine-5-carboxylate

合成工艺路线路线简述

  • 33458-27-4 = 95928-49-7
    反应条件:1.1 Reagents: Bromine Solvents: Acetic Acid; 1.5 H,Reflux
    标题:Treatment Of Cancers Having K-Ras Mutations Using Pi3 Kinase And Hdac Inhibitors And Preparation Of Bifunctional Thienopyrimidine Compounds That Inhibit Both Enzymes
    参考文献:World Intellectual Property Organization]

    33458-27-4 = 95928-49-7
    反应条件:1.1 Reagents: Bromine Solvents: Acetic Acid; Rt -> Reflux; 1.5 H,Reflux
    标题:Preparation Of Tetrahydroindazoles As Hsp90 Inhibitors Containing A Zinc Binding Moiety
    参考文献:World Intellectual Property Organization]

    33458-27-4 = 95928-49-7
    反应条件:1.1 Reagents: Bromine Solvents: Acetic Acid; 1.5 H,Rt -> Reflux
    标题:Preparation Of Oxazolylmethylthio Thiazoles As Cdk Inhibitors Containing A Zinc Binding Moiety
    参考文献:World Intellectual Property Organization]

    33458-27-4 = 95928-49-7
    反应条件:1.1 Reagents: Acetic Acid,Bromine; 2 H,Reflux
    标题:Thieno[3,2-D]Pyrimidine Derivs In Combination Therapy As A Phosphoinositide 3-Kinase Inhibitor With A Zinc Binding Moiety And Their Preparation
    参考文献:World Intellectual Property Organization]

    33458-27-4 = 95928-49-7
    反应条件:1.1 Reagents: Bromine Solvents: Acetic Acid; 1.5 H,Reflux
    标题:Deazapurines,Thienopyrimidines And Furopyrimidines As Phosphoinositide 3-Kinase Inhibitors With A Zinc Binding Moiety And Their Preparation And Use In The Treatment Of Diseases
    参考文献:United States]

    33458-27-4 = 95928-49-7
    反应条件:1.1 Reagents: Bromine Solvents: Acetic Acid; 1.5 H,Rt -> Reflux
    标题:Preparation Of Quinazoline Compounds Containing Zinc Binding Moiety As Anti-Proliferative Agents
    参考文献:World Intellectual Property Organization]

    33458-27-4 = 95928-49-7
    反应条件:1.1 Reagents: Bromine Solvents: Acetic Acid; 1.5 H,Rt -> Reflux
    标题:Isoxazole Derivatives As Hsp90 Inhibitors,Their Preparation,Pharmaceutical Compositions,And Use In The Treatment Of Cell Proliferative Diseases
    参考文献:World Intellectual Property Organization]

    33458-27-4 = 95928-49-7
    反应条件:1.1 Reagents: Bromine Solvents: Acetic Acid; 2 H,Reflux
    标题:Preparation Of Thienopyrimidine Derivatives And Their Use In Combination Therapy With A Phosphoinositide 3-Kinase Inhibitor With A Zinc Binding Moiety
    参考文献:United States]

    33458-27-4 = 95928-49-7
    反应条件:1.1 Reagents: Bromine Solvents: Acetic Acid; 3 H,110 °C; < 110 °C; 12 H,Rt
    标题:Design And Synthesis Of Novel Androgen Receptor Antagonists Via Molecular Modeling
    作者:Zhao,Chao; Choi,You Hee; Khadka,Daulat Bikram; Jin,Yifeng; Lee,Kwang-Youl; Et Al
    参考文献:Bioorganic & Medicinal Chemistry 日期:2016 卷标:24(4) 页码:789-801]

    91978-81-3 = 95928-49-7
    反应条件:1.1 Reagents: Sodium Hydroxide Solvents: Water; Rt1.2 Reagents: Sodium Bicarbonate Solvents: Water; Ph 4,Rt; 2 H,Rt
    标题:Preparation Of Heteroaromatics As Inhibitors Of Stearoyl-Coa Delta-9 Desaturase (Scd9).
    参考文献:World Intellectual Property Organization]

    = 95928-49-7 [标题:Reaction Conditions
    标题:Heteroaromatic Compounds As Inhibitors Of Stearoyl-Coenzyme A Delta-9 Desaturase
    参考文献:United States
📜Ethyl 2-Oxo-1,2,3,4-Tetrahydropyrimidine-5-Carboxylate置于溴,溶剂黄146体系中,化学反应 1.5H,以3.6 G的收率获得产物2-羟基嘧啶-5-羧酸乙酯
参考文献:Treatment Of Cancers Having K-Ras Mutations
标题:Treatment Of Cancers Having K-Ras Mutations
摘要:本发明提供了一种治疗与k-Ras突变相关的癌症的方法,适用于需要该方法的受试者.该方法包括以下步骤:(1)识别患有与k-Ras突变相关的癌症的受试者;和(2)向受试者施用(i)pi3激酶抑制剂和(II)hdac抑制剂,其中pi3激酶抑制剂和hdac抑制剂以联合治疗有效的剂量进行施用.

海关参考信息

专利信息


专利号:US-2011152295-A1
优先权日:2008-09-08
标 题:Heteroaromatic compounds as inhibitors of stearoyl-coenzyme a delta-9 desaturase
发明人：LECLERC JEAN-PHILIPPE; LI CHUN SING; RAMTOHUL YEEMAN K
权利人:LECLERC JEAN-PHILIPPE; LI CHUN SING; RAMTOHUL YEEMAN K
摘要:Heteroaromatic compounds of structural formula I are selective inhibitors of stearoyl-coenzyme A delta-9 desaturase (SCD1) relative to other known stearoyl-coenzyme A desaturases. The compounds of the present invention are useful for the prevention and treatment of conditions related to abnormal lipid synthesis and metabolism, including cardiovascular disease, such as atherosclerosis; obesity; diabetes; neurological disease; metabolic syndrome; insulin resistance; and liver steatosis.

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合成参考文献


参考文献:10.1007/s13738-012-0097-0
摘要:Memarian HR, Soleymani M, Sabzyan H. Light-induced dehydrogenation of 2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxamides. Journal of the Iranian Chemical Society. 2012 May 04;9(5):805–13. doi: 10.1007/s13738-012-0097-0.
参考文献:10.1134/s1070363217040284
摘要:Gorjizadeh M, Afshari M. 4-Bis(triphenylphosphonium)-2-butene peroxodisulfate as an efficient oxidizing agent for one-pot synthesis of ethyl pyrimidin-2(1H)-one-5-carboxylates. Russian Journal of General Chemistry. 2017 Apr;87(4):842–5. doi: 10.1134/s1070363217040284.
参考文献:10.1007/bf03246543
摘要:Memarian HR, Farhadi A. Potassium peroxydisulfate as an efficient oxidizing agent for conversion of ethyl 3,4-dihydropyrimidin-2(1H)-one-5-carboxylates to their corresponding ethyl pyrimidin-2(1H)-one-5-carboxylates. Journal of the Iranian Chemical Society. 2009 Sep;6(3):638–46. doi: 10.1007/bf03246543.
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