CAS: 956003-79-5; 5-Bromo-8-Chloroisoquinoline

该化合物是一种杂交有机化合物,其特点是其异丙醇结构,由一个有引信的苯和环组成,在5和8个位置分别存在溴和氯的替代成分,有助于其独特的化学特性和回活性.该化合物通常表现出黄色至褐色的青色外观,在二甲基硫氧化物和乙醇等有机溶剂中可溶解,但水溶性有限.其分子结构允许在药用化学中,特别是在制药业中的潜在应用,因为生物活动往往与卤化异丙醇相关.此外,5-Bromo-8-氯基酮可能参与各种化学反应,包括核生殖器替代和混合反应,使其成为有机合成中有价值的中间体.在处理该化合物时,应注意安全防范措施,因为卤化化合物可能构成健康风险和环境关切.

结构式图片

相似化合物

1215767-86-4 1824270-14-5 927801-25-0

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MSDS等安全信息

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ECHA物质C&L通报

上下游产品

5-bromoisoquinoline isoquinoline 2-(5-chloro-2-fluoro-phenyl)-4-(8-chloro-isoquinolin-5-yl)-[1,8]naphthyridine

合成工艺路线路线简述

  • 合成目标产物 5-Bromo-8-Chloroisoquinoline 主要起始原料 5-Bromoisoquinoline
  • 34784-04-8 = 956003-79-5
    反应条件:1.1 Reagents: Chlorosuccinimide,Sulfuric Acid; 0 °C; 2 H,80 °C1.2 Reagents: Ammonium Hydroxide Solvents: Water; Neutralized
    标题:1,6-Naphthyridin-5(6H)-One Compounds As Hpk1 Antagonists And Their Preparation,Pharmaceutical Compositions And Use In The Treatment Of Cancer
    参考文献:World Intellectual Property Organization]

    90721-35-0 = 956003-79-5
    反应条件:1.1 Reagents: Sodium Nitrite,Hydrochloric Acid Solvents: Water; 0 °C1.2 Reagents: Hydrochloric Acid,Cuprous Chloride Solvents: Water; 75 °C; 18 H,Rt1.3 Reagents: Sodium Hydroxide Solvents: Water; Basified
    标题:Preparation Of Dibenzo[b,E][1,4]Diazepin-11-Ones As Kinase Inhibitors For Treatment Of Cancer
    参考文献:United States]

    34784-04-8 = 956003-79-5
    反应条件:1.1 Reagents: Trichloroisocyanuric Acid,Sulfuric Acid; 0 °C; 0 °C -> 25 °C; Overnight,25 °C1.2 Reagents: Ammonia Solvents: Water; Basified,Cooled
    标题:Regioexhaustive Functionalization Of The Carbocyclic Core Of Isoquinoline: Concise Synthesis Of Oxoaporphine Core And Ellipticine
    作者:Horvath,Daniel Vajk; Domonyi,Frigyes; Palko,Roberta; Lomoschitz,Andrea; Soos,Tibor
    参考文献:Synthesis 日期:2018 卷标:50(11) 页码:2181-2190]

    34784-04-8 = 956003-79-5
    反应条件:1.1 Reagents: Chlorosuccinimide,Sulfuric Acid; Rt; 5 D,80 °C1.2 Reagents: Water; Cooled1.3 Reagents: Ammonium Hydroxide Solvents: Water; Ph 8
    标题:Preparation Of 5-Benzylisoquinoline Derivatives As Rock Kinase For The Treatment Of Cardiovascular Diseases
    参考文献:France
📜5-溴异喹啉置于三氯异氰尿酸,硫酸体系中,用88%的收率获得产物5-溴-8-氯异喹啉
参考文献:异喹啉碳环核的区域穷竭功能化:氧杂卟啉核和玫瑰树碱的合成
标题:异喹啉碳环核的区域穷竭功能化:氧杂卟啉核和玫瑰树碱的合成
摘要:摘要 已经开发了用于异喹啉碳环核心功能化的通用且通用的策略.这种区域穷举性方法采用亲电子卤化作为工具箱方法,并提供了装饰精美的中间体,可以将其进一步加工成与医学相关的构件或天然产物. 已经开发了用于异喹啉碳环核心功能化的通用且通用的策略.这种区域穷举性方法采用亲电子卤化作为工具箱方法,并提供了装饰精美的中间体,可以将其进一步加工成与医学相关的构件或天然产物.
DOI:10.1055/s-0037-1609153

海关参考信息

专利信息


专利号:JP-4120709-B2
优先权日:1995-11-07
标 题:Synthesis of organic diurethanes and / or polyurethanes and their use for the production of diisocyanates and / or polyisocyanates

专利号:JP-H11514659-A
优先权日:1995-11-07
标题:Synthesis of organic diurethanes and / or polyurethanes and their use for the production of diisocyanates and / or polyisocyanates

专利号:CN-116715611-B
优先权日:2023-05-19
标 题:A green synthesis method of 4,4'-dichlorodiphenyl sulfone

专利号:CN-116715611-A
优先权日:2023-05-19
标 题:A green synthesis method of 4,4’-dichlorodiphenylsulfone

专利号:CN-114773224-A
优先权日:2022-04-29
标 题:A kind of method of amide dehydration synthesis nitrile compound

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合成参考文献


参考文献:10.1055/s-0037-1609153
摘要:Soós T, Horváth D, Domonyi F, Palkó R, Lomoschitz A. Regioexhaustive Functionalization of the Carbocyclic Core of Isoquinoline: Concise Synthesis of Oxoaporphine Core and Ellipticine. Synthesis. 2018 Mar 07;50(11):2181–90. doi: 10.1055/s-0037-1609153.
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