CAS: 951661-81-7; (1R,3R)-1-(Benzo[d][1,3]Dioxol-5-yl)-2-(2-Chloroacetyl)-N-Methyl-2,3,4,9-Tetrahydro-1H-Pyrido[3,4-B]Indole-3-Carboxamide

英文名称(1R,3R)-1-(Benzo[d][1,3]Dioxol-5-yl)-2-(2-Chloroacetyl)-N-Methyl-2,3,4,9-Tetrahydro-1H-Pyrido[3,4-B]Indole-3-Carboxamide
中文名称他达拉非杂质D
IUPAC名称(1R,3R)-1-(benzo[d][1,3]dioxol-5-yl)-2-(2-chloroacetyl)-N-methyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxamide
其它别名Tadalafil Impurity D; Tadalafil Ep Impurity D; Tadalafil Ep Impurity J; 1H-Pyrido[3,4-B]Indole-3-Carboxamide, 1-(1,3-Benzodioxol-5-yl)-2-(2-Chloroacetyl)-2,3,4,9-Tetrahydro-N-Methyl-, (1R,3R)-; (1R,3R)-1-(1,3-Benzodioxol-5-yl)-2-(2-Chloroacetyl)-2,3,4,9-Tetrahydro-N-Methyl-1H-Pyrido[3,4-B]Indole-3-Carboxamide; Tdf-M2-Jxa; (1R,3R)-1-(Benzo[d][1,3]Dioxol-5-yl)-2-(2-Chloroacetyl)-N-Methyl-2,3,4,9-Tetrahydro-1H-Pyrido[3,4-B]Indole-3-Carboxamide (Tadalafil Impurity）; Tdf-M2-Formamide Impurity
CAS编号951661-81-7
MFCD编号:MFCD21363859
分子式:C22H20ClN3O4分子量:425.87
产品CID: 2003920
产品分类分析化学 → 标准品 → 药典标准品和杂质标准品

相似结构搜索
InChIKey: PCNIZAHOODODDG-IIBYNOLFSA-N
PCNIZAHOODODDG-IIBYNOLFSA-N
计算化学: 氢键受体数4.0氢键供体数2.0可旋转键数3.0

MSDS等安全信息

上下游产品

(1R,3R)-1-(benzo[d][1,3]dioxol-5-yl)-N-methyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxamide chloroacetyl chloride 20H19N3O3C20H19N3O3(6R,12aR)-2,3,6,7,12,12a-hexahydro-2-methyl-6-(3,4-methylenedioxyphenyl)-pyrazino[2',1':6,1]pyrido[3,4-b]indole-1,4-dione

合成工艺路线路线简述

79-04-9 + 951661-83-9 = 951661-81-7 + 951661-84-0
反应条件:1.1 Reagents: Triethylamine Solvents: Dichloromethane; 30 °C -> 5 °C1.2 Solvents: Dichloromethane; 1 - 2 H,-5 - 5 °C; 30 Min,0 - 5 °C1.3 Reagents: Sodium Bicarbonate Solvents: Water; 15 Min,10 °C -> 30 °C
标题:Process For Preparation Of Tadalafil
参考文献:World Intellectual Property Organization]

171489-59-1 = 951661-81-7
反应条件:1.1 Solvents: Methanol,Water; Rt -> 50 °C; 6 H,50 °C; 50 °C -> 0 °C; 1 H,0 °C
标题:Process For Preparation Of β-Carboline Derivatives Via Pictet-Spengler Reaction Of Tryptophan With Piperonal In The Presence Of Inorganic Acid.
参考文献:World Intellectual Property Organization