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专利信息
专利号:US-7473541-B2
优先权日:2004-07-09
标 题:Identification, cloning, expression, and purification of three novel human calcium-independent phospholipase A2 family members possessing triacylglycerol lipase and acylglycerol transacylase activities
发明人:GROSS RICHARD W; JENKINS CHRISTOPHER
权利人:GROSS RICHARD W; JENKINS CHRISTOPHER
摘要:Isolated novel and purified and characterized phospholipase A 2 , referred to herein as calcium-independent phospholipase A 2 zeta (iPLA 2 zeta) having SEQ. ID. NO: 2 (See FIG. 1 ), and nucleic acid sequence (SEQ. ID. NO: 4), and calcium-independent phospholipase A 2 eta (iPLA 2 eta) having SEQ. ID. NO: 3 (See FIG. 1 ), and nucleic acid sequences (SEQ. ID. NO: 5). For the first time herein, these novel enzymes have been isolated and characterized and are involved in the catalysis, synthesis and hydrolysis of lipids in a living mammalian cell. Moreover, these enzymes iPLA 2 zeta and iPLA 2 eta through the process of transesterification can catalyze the net anabolic synthesis of triglycerides through a variety of metabolic precursors (e.g. monoacylglycerol, diacylglycerol and acyl CoA).
专利号:EP-0542969-B1
优先权日:1991-06-04
标 题:Biodegradable particulate vector and method of synthesis
发明人:SAMAIN DANIEL; DE MIGUEL IGNACIO; MENIALI JAOUAD; IOUALALEN KARIM; DING LI; CERVILLA MONIQUE; RIEUMAJOU VALERIE; DELRIEU PASCAL; IMBERTIE LAURENT
权利人:BIOVECTOR THERAPEUTICS SA
摘要:A biodegradable particulate vector is disclosed and is characterized in that it comprises: a nucleus consisting of a cross-linked polysaccharide or oligosaccharide matrix to which ionic ligands are attached; a first semi-permeable lipid layer linked to the nucleus by covalent bonds; a second layer of amphiphilic compounds linked to the first lipid layer by hydrophobic interactions. A method for synthesis of said vector is also disclosed.
专利号:US-10022459-B2
优先权日:2011-06-13
标题 :Medical tissue-marker and manufacturing method for the same
发明人:HAYASHI HIDEKI; HATAYAMA HIROSUKE; FUJINAMI MASANORI; TOYOTA TARO
权利人:HAYASHI HIDEKI; HATAYAMA HIROSUKE; FUJINAMI MASANORI; TOYOTA TARO; UNIV CHIBA NAT UNIV CORP
摘要:A medical tissue-marker which enables the identification of a location even from the outside of an organ, can remain topical over a long period, and enables the easy identification of a marked location within the whole organ; also a manufacturing method for the medical tissue-marker. The medical tissue-marker includes a vesicle formed by the synthesis of a phospholipid and a near infrared fluorescent dye, and an emulsion formed by the synthesis of the phospholipid and an X-ray contrast medium, and has agglomerated clusters wherein the vesicle and the emulsion are contained in a hydrophilic solvent and a plurality of capsules are formed by use of an emulsifier.
专利号:CN-102971014-A
优先权日:2010-06-29
标 题 :Synthesis of High Performance Iron Oxide Particle Tracers for Magnetic Particle Imaging (MPI)
专利号:CN-106188169-A
优先权日:2016-07-07
标题 :Synthesis of a Lipid Derivative Containing Sialic Acid Group and Its Application in Pharmaceutical Preparations
专利号:CN-106188169-B
优先权日:2016-07-07
标 题 :Synthesis of a lipid derivative containing sialic acid group and its application in pharmaceutical preparations