CAS: 933041-13-5; 4-Bromo-6-Chloropyridazin-3(2H)-One
相似化合物
22626-56-8 5788-58-9 1178884-53-1MSDS等安全信息
- GHS象形图
- GHS符号GHS07 & GHS05;
注释: Exclamation mark & Corrosion - 危险类别急性毒性 类别4(吸入)
急性毒性 类别4(经口)
特定目标器官毒性 - 单次接触 类别3
皮肤腐蚀/刺激 类别2
严重眼损伤 类别1
急性毒性 类别4(经皮)
严重眼刺激 类别2
呼吸道致敏 类别1
皮肤致敏 类别1 - 警示词Danger(危险)
- 危险描述H332 |吸入有害.
H302 |吞咽有害.
H335 |可能引起呼吸道刺激.
H315 |造成皮肤刺激.
H318 |造成严重眼损伤.
H312 |皮肤接触有害.
H319 |造成严重眼刺激.
H334 |吸入可能引起过敏或哮喘症状或呼吸困难.
H317 |可能引起皮肤过敏反应. - 防范说明P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
欧盟法规
C&L通报上下游产品
3-羟基-6-氯哒嗪 6-Chloro-2H-Pyridazin-3-One 19064-67-6合成工艺路线路线简述
- 19064-67-6 = 933041-13-5
反应条件:1.1 Reagents: Potassium Acetate,Bromine,Potassium Bromide Solvents: Water; 2 H,Reflux; Reflux -> Rt
标题:Preparation Of Pyridazinones And Their Use As Btk Inhibitors
参考文献:World Intellectual Property Organization]
446273-59-2 = 933041-13-5
反应条件:1.1 Reagents: Sodium Nitrite,Sulfuric Acid Solvents: Acetic Acid,Water; 0 - 5 °C; 1 H,20 °C1.2 Solvents: Water; 5 H,Rt
标题:Preparation Of Novel Substituted Pyridin-2-Ones And Pyridazin-3-Ones
参考文献:World Intellectual Property Organization]
446273-59-2 = 933041-13-5
反应条件:1.1 Reagents: Sodium Nitrite,Sulfuric Acid Solvents: Acetic Acid,Water; 1 H,20 °C1.2 Solvents: Water; 5 H,Rt
标题:Preparation Of 5-Phenyl-1H-Pyridin-2-One,6-Phenyl-2H-Pyridazin-3-One,And 5-Phenyl-1H-Pyrazin-2-One Derivatives As Inhibitors Of Bruton'S Tyrosine Kinase
参考文献:United States]
446273-59-2 = 933041-13-5
反应条件:1.1 Reagents: Acetic Acid,Sodium Nitrite,Sulfuric Acid Solvents: Water; 0 - 5 °C; 1 H,20 °C1.2 Solvents: Water; 5 H,Rt
标题:Preparation Of Pyridinones And Pyridazinones As Bruton'S Tyrosine Kinase (Btk) Inhibitors.
参考文献:United States]
446273-59-2 = 933041-13-5
反应条件:1.1 Reagents: Sodium Nitrite,Sulfuric Acid Solvents: Acetic Acid,Water; 0 - 5 °C; 30 Min,0 °C; 0 °C -> Rt; 1 H,Rt1.2 Reagents: Water; 4 H,Rt
标题:Biaryl Amide Compounds As Kinase Inhibitors And Their Preparation
参考文献:World Intellectual Property Organization]
5469-69-2 = 933041-13-5
反应条件:1.1 Reagents: Sulfuric Acid,Bromine Solvents: Dichloromethane; 10 H,30 °C1.2 Reagents: Sodium Nitrite,Sulfuric Acid Solvents: Water; 8 H,60 °C
标题:Synthetic Method Of 4-Bromo-6-Chloropyridazin-3(2H)-One
参考文献:China]
19064-67-6 = 933041-13-5
反应条件:1.1 Reagents: Bromine Solvents: Water; 2 D,90 °C
标题:Studies On Improved Synthesis Of 2'-Deoxyribonucleosides Of Pyridazine Derivatives
作者:Kazimierczuk,Zygmunt; Kaminski,Jaroslaw; Meggio,Flavio
参考文献:Collection Of Czechoslovak Chemical Communications 日期:2006 卷标:71(6) 页码:889-898]
446273-59-2 = 933041-13-5
反应条件:1.1 Reagents: Acetic Acid,Sodium Nitrite,Sulfuric Acid Solvents: Water; 0 - 5 °C; 1 H,20 °C1.2 Solvents: Water; 5 H,Rt
标题:Preparation Of Pyridinones And Pyridazinones As Bruton'S Tyrosine Kinase (Btk) Inhibitors.
参考文献:World Intellectual Property Organization]
446273-59-2 = 933041-13-5
反应条件:1.1 Reagents: Sodium Nitrite,Sulfuric Acid Solvents: Acetic Acid; 0 - 5 °C; 30 Min,0 °C; 1 H,25 °C1.2 Solvents: Water; 4 H,25 °C
标题:Design And Discovery Of N-(3-(2-(2-Hydroxyethoxy)-6-Morpholinopyridin-4-Yl)-4-Methylphenyl)-2-(Trifluoromethyl)Isonicotinamide,A Selective,Efficacious,And Well-Tolerated Raf Inhibitor Targeting Ras Mutant Cancers: The Path To The Clinic
作者:Ramurthy,Savithri; Taft,Benjamin R.; Aversa,Robert J.; Barsanti,Paul A.; Burger,Matthew T.; Et Al
参考文献:Journal Of Medicinal Chemistry 日期:2020 卷标:63(5) 页码:2013-2027]
446273-59-2 = 933041-13-5
反应条件:1.1 Reagents: Sodium Nitrite,Sulfuric Acid Solvents: Acetic Acid; 30 Min,0 °C; 0 °C -> Rt; 1 H,Rt1.2 Reagents: Water; 4 H,Rt
标题:Preparation Of Biaryl Amide Compounds As Raf Kinase Inhibitor
参考文献:United States]
446273-59-2 = 933041-13-5
反应条件:1.1 Reagents: Sodium Nitrite,Sulfuric Acid Solvents: Acetic Acid; 0 - 5 °C; 1 H,20 °C1.2 Reagents: Water; 5 H,Rt
标题:Preparation Of Isoxazoline Derivatives As Inhibitors Of Matrix Metalloproteinase Mmp-13 And Therapeutic Agents
参考文献:World Intellectual Property Organization]
19064-67-6 = 933041-13-5
反应条件:1.1 Reagents: Potassium Acetate,Potassium Bromide Solvents: Water; 15 Min,Rt1.2 Reagents: Bromine; 2 H,90 °C1.3 Reagents: Sodium Thiosulfate Solvents: Water
标题:Preparation Of 2-(Hetero)Aryl-Substituted 2-Pyridazinyl-3(2H)-One Derivatives As Fgfr Tyrosine Kinase Inhibitors
参考文献:World Intellectual Property Organization]
19064-67-6 = 933041-13-5
反应条件:1.1 Reagents: Sodium Acetate,Bromine,Potassium Bromide Solvents: Water; Rt; 2 H,Reflux
标题:Preparation Of Antibody Drug Conjugates With Nampt Inhibitors For Use In Treatment Of Cancer
参考文献:World Intellectual Property Organization]
19064-67-6 = 933041-13-5
反应条件:1.1 Reagents: Potassium Acetate,Bromine,Potassium Bromide Solvents: Water; Rt -> Reflux; Overnight,Reflux
标题:Preparing Method And Application Of Pyridazinone-Based Histone Deacetylase Inhibitor
参考文献:China]
19064-67-6 = 933041-13-5
反应条件:1.1 Reagents: Potassium Acetate,Bromine,Potassium Bromide Solvents: Water; Rt; 2 H,100 °C
标题:Preparation Of Pyridazine Derivatives As Smarca2/4 Degraders
参考文献:World Intellectual Property Organization]
19064-67-6 = 933041-13-5
反应条件:1.1 Reagents: Potassium Acetate,Bromine,Potassium Bromide Solvents: Water; 25 °C; 2 H,100 °C; 100 °C -> Rt1.2 Reagents: Sodium Sulfite Solvents: Water; 0 °C
标题:Pyrazolo[1,5-A]Pyrimidine Compounds Useful In The Treatment Of Cancer,Autoimmune And Inflammatory Disoders
参考文献:World Intellectual Property Organization]
19064-67-6 = 933041-13-5
反应条件:1.1 Reagents: Potassium Acetate,Bromine,Potassium Bromide Solvents: Water; 2 H,100 °C
标题:Preparation Of Pyridazinone Or Pyridinone Compounds As Parp7 Inhibitors Useful In Treatment Of Cancers
参考文献:World Intellectual Property Organization]
19064-67-6 = 933041-13-5
反应条件:1.1 Reagents: Potassium Acetate,Bromine,Potassium Bromide Solvents: Water; Rt; 2 H,100 °C
标题:N-Phenyl-2-(3-Phenyl-6-Oxo-1,6-Dihydropyridazin-1-Yl)Acetamide Derivatives For Treating Cystic Fibrosis
参考文献:World Intellectual Property Organization
📜3-氨基-4-溴-6-氯哒嗪置于硫酸,溶剂黄146,Sodium Nitrite体系中,用 水 作为反应溶剂,化学反应生成 4-溴-6-氯吡嗪-3(2H)-酮
参考文献:Pi3K/hdac双重抑制剂新型吡嗪酮衍生物的设计,合成及生物学评价
标题:Pi3K/hdac双重抑制剂新型吡嗪酮衍生物的设计,合成及生物学评价
摘要:Pi3Ks和hdacs在白血病的发生和发展中起着重要作用.在此,基于支架置换和杂合策略,合理设计和合成了一系列新型吡嗪-2(1 H)-酮衍生物作为新型双重 Pi3K 和 Hdac 抑制剂.大多数目标化合物对 Pi3Kα 和 Hdac6 显示出强大的抑制效力.特别是,化合物9Q对 Pi3Kα 和 Hdac6 具有抑制作用,Ic 50值为 372 Nm 和 4.5 Nm,对 Mv4-11 细胞具有抗增殖活性,Ic 50值为 0.093 +/-0.012 μm.进一步的机理研究表明9Q诱导细胞凋亡,使细胞周期停滞在g2/m期,促进α-微管蛋白的乙酰化,阻断mv4-11细胞中的pi3K/akt/mtor信号通路.所有结果表明,9Q是进一步开发用于白血病治疗的新型 Pi3K/hdac 双重抑制剂的有前途的主要候选者.
DOI:10.1016/j.Bmc.2022.117067
