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CAS号78-83-1 异丁醇 | CAS号75-28-5 异丁烷 | CAS号115-11-7 2-甲基丙烯 | CAS号106-97-8 丁烷 | CAS号161616-29-1 2-isobutoxy-4-m... | CAS号29015-35-8 triisobutyl ant... | CAS号513-38-2 碘代异丁烷 | CAS号513-36-0 氯代异丁烷 | CAS号1116-39-8 triisobutylborane | CAS号30762-00-6 4-异丁氧基苯甲酸 | CAS号542-56-3 亚硝酸异丁酯 | CAS号625-74-1 2-甲-1-硝丙烷 | CAS号32741-05-2 2-异丁基噻吩 | CAS号542-54-1 4-甲基戊腈 | CAS号56311-39-8 5-叔丁基呋喃-2-羧酸 | CAS号544-01-4 异戊醚 | CAS号39520-24-6 异丁基丙二酸二甲酯 | CAS号4439-24-1 乙二醇单异丁醚 | CAS号513-44-0 异丁硫醇

异丁醇置于三溴化磷体系中,化学反应生成 溴代异丁烷
参考文献:Synthesis Of Some 2'-C-Alkyl Derivatives Of 9-(2-Phosphonomethoxyethyl)Adenine And Related Compounds
标题:Synthesis Of Some 2'-C-Alkyl Derivatives Of 9-(2-Phosphonomethoxyethyl)Adenine And Related Compounds
摘要:为了研究9-(2-磷酸甲氧基乙基)腺嘌呤(ia)的2'-烷基衍生物中β-取代对抗病毒活性或基团特异性的影响,合成了这些衍生物.通过将腺嘌呤与适当取代的环氧烷(xiii)或2-羟基烷基对甲苯磺酸酯(iv和vi)烷基化制备了9-(2-羟基烷基)腺嘌呤(viii).在通过苯甲酰化(化合物ix)或酰胺化(化合物x)保护腺嘌呤氨基后,中间体在氢化钠存在下与二异丙基对甲苯磺酸氧甲基膦酸酯(xi)烷基化.去保护后,得到的膦酸二酯(xii)通过转硅烷化和水解转化为膦酸(i).这种合成方案用于制备乙基(ie),丙基(if),2-丙基(ig),2-甲基丙基(ih),环丙基(II),环己基(ij),苄基(ik)和苯基(il)衍生物.2'-三氟甲基衍生物(xxiia)类似地从9-(2-羟基-3,3,3-三氟丙基)腺嘌呤(xxa)制备,后者通过腺嘌呤钠盐与2-羟基-3,3,3-三氟丙基溴化物烷基化获得.2'-三甲基硅基衍生物(xixa)通过腺嘌呤与2-二异丙基膦酸甲氧基-3-(4-对甲苯磺酰氧基)丙基三甲基硅烷(xvii)烷基化后,转硅烷化和水解膦酸二酯(xviiia)获得.2,6-二氨基嘌呤衍生物(xviiid和xxiib)类似地获得.9-(3-磷酸甲氧基丁基)腺嘌呤(xxviii)和9-(2-甲基-2-磷酸甲氧基丙基)腺嘌呤(xxxv)分别从相应的羟基衍生物(xxvib和xxxii)通过与衍生物i相同的反应途径制备.
DOI:10.1135/cccc19942069

专利信息

专利号:US-9126995-B2
优先权日:2011-11-08
标题:Method for catalytic asymmetric synthesis of optically active isoxazoline compound and optically active isoxazoline compound
发明人：TOYAMA KEN-ICHI; MORIYAMA YUJI; MATOBA KAZUTAKA; YAOSAKA MANABU; IKEDA EITATSU
权利人:NISSAN CHEMICAL IND LTD
摘要:There is provided a method for catalytic asymmetric synthesis of optically active isoxazoline compound and an optically active isoxazoline compound. A method for catalytic asymmetric synthesis of optically active isoxazoline compound of a formula (6) including reacting an α,β-unsaturated carbonyl compound of a formula (1) and a hydroxylamine in a solvent in the presence of a base by adding a chiral phase transfer catalyst. An optically active isoxazoline compound of a formula (13) that can be synthesized by the method.

专利号:US-4277610-A
优先权日:1975-01-27
标 题 :Synthesis of 2,6,10-trimethyl-undecan-1-ol
发明人：COHEN NOAL; SAUCY GABRIEL
权利人:HOFFMANN LA ROCHE
摘要:A synthesis of 2,6,10-trimethyl-undecan-1-ol, an intermediate for producing vitamin E, from methacrolein, crotonaldehyde, β-hydroxy-isobutyric acid including intermediates in this synthesis.

专利号:US-4163021-A
优先权日:1975-01-27
标 题 :Synthesis of 2,6,10-trimethyl-undecan-1-ol
发明人：COHEN NOAL; SAUCY GABRIEL
权利人:HOFFMANN LA ROCHE
摘要:A synthesis of 2,6,10-trimethyl-undecan-1-ol, an intermediate for producing vitamin E, from methacrolein, crotonaldehyde, β-hydroxy-isobutyric acid including intermediates in this synthesis.

专利号:US-4041058-A
优先权日:1975-01-27
标题 :Synthesis of 2,6,10-trimethyl-undecan-1-ol
发明人：COHEN NOAL; SAUCY GABRIEL
权利人:HOFFMANN LA ROCHE
摘要:A synthesis of 2,6,10-trimethyl-undecan-1-ol, an intermediate for producing vitamin E, from methacrolein, crotonaldehyde, β-hydroxy-isobutyric acid including intermediates in this synthesis.

专利号:US-5554753-A
优先权日:1993-08-25
标 题:Catalytic enantioselective synthesis of α-amino acid derivatives by phase-transfer catalysis
发明人：O'DONNELL MARTIN J; WU SHENGDE; ESIKOVA IRENA; MI AIQIAO
权利人:INDIANA UNIVERSITY FOUNDATION
摘要:Described are improved processes for the enantioselective synthesis of α-amino acids which involve combinations of solvents, highly-mixed and low-temperature reaction conditions, and novel catalysts. Also described are novel catalysts and precursors to α-amino acid derivatives.

专利号:US-6875866-B2
优先权日:2002-02-21
标题:Process for synthesis of D1 receptor antagonists
发明人：DAHANUKAR VILAS H; ECKERT JEFFREY M; GALA DINESH; LUCAS BRIAN; SCHUMACHER DORIS P; ZAVIALOV ILIA
权利人:SCHERING CORP
摘要:In one embodiment, the present invention describes the synthesis of a compound of formula n n nand intermediates therefor.