CAS: 76-75-5; Thiopentone

结构式图片

欧盟法规

REACH注册ECHA物质ECHA物质C&L通报REACH预注册

上下游产品

H-pyrimidin-4-one5-ethyl-6-amino-5-(1-methyl-butyl)-2-thioxo-3,5-dihydro-2H-pyrimidin-4-one pentobarbital thiourea 2-bromopentane 5-Ethyl-2-(2-methoxy-phenylimino)-5-(1-methyl-butyl)-dihydro-pyrimidine-4,6-dione 5-Ethyl-5-(1-methyl-butyl)-2-p-tolylimino-dihydro-pyrimidine-4,6-dione 5-Ethyl-2-(4-methoxy-phenylimino)-5-(1-methyl-butyl)-dihydro-pyrimidine-4,6-dione 5-Ethyl-5-(1-methyl-butyl)-2-phenylimino-dihydro-pyrimidine-4,6-dione

合成工艺路线路线简述

  • 合成目标产物 (+/-)-Thiopental 主要起始原料 Ethyl 1-Methylbutyl Cyanoacetate
  • (文献来源)合成步骤主要原料 Ethyl 1-Methylbutyl Cyanoacetate
📜2-Ethyl-2-Cyano-3-Methyl-Hexanoic Acid Methyl Ester置于硫酸体系中,化学反应生成 (+/-)-戊硫代巴比妥
参考文献:Abe Et Al.,Yakugaku Zasshi/journal Of The Pharmaceutical Society Of Japan,1955,Vol. 75,P. 891
标题:Abe Et Al.,Yakugaku Zasshi/journal Of The Pharmaceutical Society Of Japan,1955,Vol. 75,P. 891

海关参考信息

专利信息


专利号:WO-0024358-A3
优先权日:1998-10-22
标题 :Synthesis and uses of thiopentone enantiomers
发明人:MATHER LAURENCE EDWARD; DUKE COLIN C
权利人:UNIV SYDNEY; MATHER LAURENCE EDWARD; DUKE COLIN C
摘要:The present invention relates to the synthesis of R- and S- thiopentone and to an improved anaesthetic agent including R-thiopentone.

专利号:EP-1886695-A1
优先权日:2006-06-27
标 题:Pharmaceutical combination of an aldosterone synthase inhibitor and a glucocorticoid receptor antagonist or a cortisol synthesis inhibitor or a corticotropin releasing factor antagonist
发明人:SCHUMACHER CHRISTOPH
权利人:SPEEDEL EXPERIMENTA AG
摘要:The invention relates to a pharmaceutical combination comprising (a) an aldosterone synthase inhibitor or a pharmaceutically acceptable salt thereof, and (b) a glucocorticoid receptor antagonist or a cortisol synthesis inhibitor or a cortisol re-synthesis inhibitor or a corticotrophin-releasing hormone receptor antagonist or combinations thereof or in each case a pharmaceutically acceptable salt thereof. Said composition is useful for the manufacture of a medicament, in particular for the manufacture of a medicament for the prevention of, delay of progression of treatment of a disease or condition characterized by the metabolic syndrome.

专利号:US-12201669-B2
优先权日:2021-03-11
标 题:Small molecule suppressors of APOE gene expression and cerebral vascular amyloid pathology
发明人:TSAI LI-HUEI; BLANCHARD JOEL
权利人:MASSACHUSETTS INST TECHNOLOGY
摘要:The present disclosure provides methods of inhibiting amyloid synthesis in a subject using small molecule inhibitors. The invention also includes methods of treating disease associated with amyloid synthesis, such as Alzheimer's disease. The small molecule inhibitors disclosed herein are compounds which are non-immunosuppressant cyclosporin including the pharmaceutically acceptable salts thereof.

专利号:WO-2011011384-A9
优先权日:2009-07-20
标 题 :Synthesis of dendrimer conjugates

专利号:PT-103420-A
优先权日:2006-01-16
标题 :USE OF THE INDUCTION PROCESS OF THE NEW SYNTHESIS OF GLYCOPROTEIN P (GP - P) IN THE TREATMENT OF XENOBIOTIC MAMMALS INTOXICATIONS

专利号:PT-103420-B
优先权日:2006-01-16
标 题 :USE OF THE INDUCTION PROCESS OF THE NEW SYNTHESIS OF GLYCOPROTEIN P (GP - P) IN THE TREATMENT OF XENOBIOTIC MAMMALS INTOXICATIONS

供应商参考报价(招募中)

品牌试剂参考报价(招募中)

📌 第三方产品分析报告

✅ COA系统入驻 | 共享模式

合成参考文献


参考文献:10.1007/s00408-010-9229-4
摘要:Leyva FJ, Roberts K. Crocidolite induces prostaglandin I(2) release mediated by vitronectin receptor and cyclooxygenase-2 in lung cells. Lung. 2010 Apr;188(2):133–41.
参考文献:10.1007/s00330-010-1716-8
摘要:Kindberg GM, Uran S, Friisk G, Martinsen I, Skotland T. The fate of Gd and chelate following intravenous injection of gadodiamide in rats. European Radiology. 2010 Feb 16;20(7):1636–43. doi: 10.1007/s00330-010-1716-8.
参考文献:10.1186/cc10317
摘要:Mekontso Dessap A, Ouanes I, Rana N, Borghi B, Bazin C, Katsahian S, Hulin A, Brun-Buisson C. Effects of discontinuing or continuing ongoing statin therapy in severe sepsis and septic shock: a retrospective cohort study. Crit Care. 2011 Jul 18;15(4):R171.
参考文献:10.1007/s00540-011-1199-z
摘要:Luo J, Min S, Wei K, Li P, Dong J, Liu YF. Propofol protects against impairment of learning-memory and imbalance of hippocampal Glu/GABA induced by electroconvulsive shock in depressed rats. J Anesth. 2011 Oct;25(5):657–65. doi: 10.1007/s00540-011-1199-z.
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