CAS: 76-06-2; Chloropicrin

化学文摘社编号76-06-2;青黄液体,具有典型的刺青味,通常被描述为类似于辣椒或芥子干粉的味道,无色无色可闻;氯丙烯主要用作杀虫剂和土壤熏蒸剂,因其对各种害虫和病原体的效力而成为农药和土壤熏蒸剂;还用于合成其他化学品和在军事用途中用作催泪瓦斯;该化合物具有剧毒性,在接触时可造成严重呼吸刺激,皮肤烧灼伤和其他健康危害;氯丙烯的沸点相对较高,有机溶剂溶解,但水溶性有限;由于其危险性质,在许多国家受到管制,在处理时,安全防范至关重要;其化学结构有3个氯原子和一个与碳原子相连的硝基,有助于其再活性和毒性.

结构式图片

欧盟法规

《欧盟PIC法规》统一分类与标签压力设备指令-第1组危险流体REACH注册ECHA物质OtherC&L通报REACH预注册废弃物危险特性清单"欧盟管控危险化学品"工作场所安全标识要求ECHA物质化妆品禁用物质清单

上下游产品

2,4-Dinitrophenol 4-nitro-phenol nitromethane chloroformtetramethoxymethane carbonic acid dimethyl ester n-Butyl chloride dibutyl chlorophosphate

合成工艺路线路线简述

    📜2,4-二硝基酚置于sodium Hypochlorite体系中,化学反应生成 氯化苦
    参考文献:Not Another Scoring System
    标题:Not Another Scoring System
    摘要:
    DOI:10.1046/j.1365-2044.2000.01557-8.X

    专利信息


    专利号:US-2016073631-A1
    优先权日:2013-03-04
    标 题 :Process for the preparation of dihydropyrrole derivatives
    发明人:EL QACEMI MYRIEM; SMITS HELMARS; CASSAYRE JEROME YVES; MULHOLLAND NICHOLAS PHILLIP; RENOLD PETER; GODINEAU EDOUARD; PITTERNA THOMAS
    权利人:SYNGENTA PARTICIPATIONS AG; SYNGENTA LTD
    摘要:The present invention provides stereoselective processes for the preparation of compounds of formula (I) n n n n n n n n n n n n wherein n P is phenyl, naphthyl, a 6-membered heteroaryl group containing one or two nitrogen atoms as ring members, or a 10-membered bicyclic heteroaryl group containing one or two nitrogen atoms as ring members, and wherein the phenyl, naphthyl and heteroaryl groups are optionally substituted; n R 1 is chlorodifluoromethyl or trifluoromethyl; n R 2 is optionally substituted aryl or optionally substituted heteroaryl; n n is 0 or 1; n including the process comprising n (a-i) reacting a compound of formula II n n n n n n n n n n n n n n n n wherein P, R 1 and R 2 are as defined for the compound of formula I; n with nitromethane in the presence a chiral catalyst to give a compound of formula III n n n n n n n n n n n n n n n n wherein P, R 1 and R 2 are as defined for the compound of formula I; and n (a-ii) reductively cyclising the compound of formula III to give the compound of formula I. n n n n n The invention also provides intermediates useful for processes for the synthesis of compounds of formula (I).

    专利号:US-9233920-B2
    优先权日:2010-06-11
    标题 :Process for the preparation of dihydropyrrole derivatives
    发明人:EL QACEMI MYRIEM; SMITS HELMARS; CASSAYRE JEROME YVES; MULHOLLAND NICHOLAS PHILLIP; RENOLD PETER; GODINEAU EDOUARD; PITTERNA THOMAS
    权利人:EL QACEMI MYRIEM; SMITS HELMARS; CASSAYRE JEROME YVES; MULHOLLAND NICHOLAS PHILLIP; RENOLD PETER; GODINEAU EDOUARD; PITTERNA THOMAS; SYNGENTA PARTICIPATIONS AG; SYNGENTA LTD
    摘要:The present invention provides stereoselective processes for the preparation of compounds of formula (I) wherein P is phenyl, naphthyl, a 6-membered heteroaryl group containing one or two nitrogen atoms as ring members, or a 10-membered bicyclic heteroaryl group containing one or two nitrogen atoms as ring members, and wherein the phenyl, naphthyl and heteroaryl groups are optionally substituted; R 1 is chlorodifluoromethyl or trifluoromethyl; R 2 is optionally substituted aryl or optionally substituted heteroaryl; n is 0 or 1; including the process comprising (a-i) reacting a compound of formula II wherein P, R 1 and R 2 are as defined for the compound of formula I; with nitromethane in the presence a chiral catalyst to give a compound of formula III Wherein P, R 1 and R 2 are as defined for the compound of formula I; and (a-ii) reductively cyclizing the compound of formula III to give the compound of formula I. The invention also provides intermediates useful for processes for the synthesis of compounds of formula (I).

    专利号:US-3689495-A
    优先权日:1969-09-04
    标 题:Synthesis of crystal violet
    发明人:LOHMANN GEORGE Y JR
    权利人:GEORGE Y LOHMANN JR
    摘要:A triphenyl methane dye, particularly crystal ciolet, is synthesized by reacting an aniline, particularly N, N-dimethyl aniline, with a carbon tetrahalide, particularly carbon tetrachloride, in the presence of aluminum chloride as a catalyst.

    专利号:US-4424385-A
    优先权日:1982-08-02
    标 题 :Synthesis of nitromethane
    发明人:MARKOFSKY SHELDON B
    权利人:GRACE W R & CO
    摘要:An improved process for forming nitromethane by contacting liquid methyl halide with an alkali or alkaline earth metal nitrite in the presence of an excess of the liquid methyl halide.

    专利号:US-2007232495-A1
    优先权日:2006-03-24
    标题:Compositions and methods to add value to plant products, increasing the commercial quality, resistance to external factors and polyphenol content thereof
    发明人:NAPPA ALVARO O; LORENZINI FELIPE C; SANHUEZA ANDRES L
    权利人:NAPPA ALVARO O; LORENZINI FELIPE C; SANHUEZA ANDRES L
    摘要:The invention is related to compositions and methods that naturally protect plant tissues against ultraviolet radiation and temperature, thus giving protection against sunburn to plants, plant parts, fruits and/or flowers during their development. The invention is also related to compositions and methods to naturally improve the color of plants, plant parts, fruits and/or flowers by inducing the natural synthesis of flavonoids and anthocyanins present in plants. Likewise, the present invention is directed to improving the nutritional value of plants, plant parts, fruits and/or flowers by increasing the normal levels of polyphenolic compounds, especially flavonoids, present therein. Additionally, the present invention is related to compositions and methods that give more resistance to plants, plant parts, fruits and/or flowers against pathogens as bacteria and fungi. Finally, the present invention is related to plants, plant parts, fruits, flowers and/or propagating material treated with the compositions described in the present document.

    专利号:US-10927139-B2
    优先权日:2012-11-22
    标 题:Chemically cleavable group
    发明人:ROBILLARD MARC STEFAN; VERSTEEGEN RONNY MATHIEU; TEN HOEVE WOLTER; ROSSIN RAFFAELLA
    权利人:TAGWORKS PHARMACEUTICALS B V
    摘要:Disclosed is the use of the reactive components of the inverse electron-demand Diels Alder reaction for chemical masking and unmasking in vitro. This can be applied in complex chemical reactions and, particularly in the synthesis of biomolecules, e.g. on solid supports. The reactive components are a dienophile, particularly a trans-cyclooctene, and a diene, particularly a tetrazine.

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    ✅ COA系统入驻 | 共享模式

    主要参考文献


    1: Lizardo-Huerta JC, Sirjean B, Verdier L, Fournet R, Glaude PA. Combustion and Pyrolysis Kinetics of Chloropicrin. J Phys Chem A. 2018 Jun 12. doi: 10.1021/acs.jpca.8b04007. [Epub ahead of print] doi: 10.1371/journal.pone.0188245. eCollection 2018. doi: 10.1016/j.chemosphere.2018.05.136. Epub 2018 May 24. doi: 10.1021/acssensors.8b00135. Epub 2018 Apr 4. doi: 10.1016/j.envres.2018.02.022. Epub 2018 Feb 23.
    6: Yao D, Chu W, Bond T, Ding S, Chen S. Impact of ClO(2) pre-oxidation on the formation of CX(3)R-type DBPs from tyrosine-based amino acid precursors during chlorination and chloramination. Chemosphere. 2018 Apr;196:25-34. doi: 10.1016/j.chemosphere.2017.12.143. Epub 2017 Dec 26. doi: 10.1016/j.chemosphere.2017.12.113. Epub 2017 Dec 19. doi: 10.1016/j.scitotenv.2017.12.060. Epub 2017 Dec 13. doi: 10.1186/s13568-017-0475-1.
    10: Desaeger J, Dickson DW, Locascio SJ. Methyl Bromide Alternatives for Control of Root-knot Nematode (Meloidogyne spp.) in Tomato Production in Florida. J Nematol. 2017 Jun;49(2):140-149.
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