CAS: 75272-39-8; (2R,3R)-Nemonapride

📜(2S,3R)-Tert-Butyl 3-(Tert-Butyldimethylsilyloxy)-2-Methyl-5-Oxopyrrolidine-1-Carboxylate 在 甲醇,4-二甲氨基吡啶,氯化亚砜,Sodium Azide,Dimethyl Sulfide Borane,氢气,氯甲酸乙酯,Sodium Hydride,三乙胺,三氟乙酸体系中,用 四氢呋喃,甲醇,二氯甲烷,N,N-二甲基甲酰胺作为反应溶剂,反应 75.25H,获得 N-((2S,3S)-1-Benzyl-2-Methylpyrrolidin-3-yl)-5-Chloro-2-Methoxy-4-(Methylamino)Benzamide
参考文献:反式-4,5-吡咯烷内酰胺的简便方法及其在合成奈莫那必和链霉吡咯烷中的应用
标题:反式-4,5-吡咯烷内酰胺的简便方法及其在合成奈莫那必和链霉吡咯烷中的应用
摘要:描述了一种从氨基酸开始反式-4-羟基吡咯烷内酰胺1的有效方法.该方法的效用已被证明在抗精神病药物的齐拉西合成3和抗血管生成streptopyrrolidine 4.从光谱和物理数据方面比较了天然链霉菌吡咯烷4的四种合成立体异构体,提出了天然产物的绝对结构为(4 S,5 S)-构型.
Doi:10.1016/J.Tet.2011.07.049

专利信息

专利号:US-10005720-B2
优先权日:2013-04-05
标题:Compounds useful for the treatment of metabolic disorders and synthesis of the same
发明人：SEXTON JONATHAN Z; BRENMAN JAY E; MUSSO DAVID L
权利人:NORTH CAROLINA CENTRAL UNIV; UNIV NORTH CAROLINA CHAPEL HILL
摘要:The present invention provides compounds of Formula (I): wherein variables X, Y, Z and R1 are as described herein. Some of the compounds described herein are glutamate dehydrogenase activators. The invention is also directed to pharmaceutical compositions comprising these compounds, uses of these compounds and compositions in the treatment of metabolic disorders as well as synthesis of the compounds.

专利号:US-2018370905-A1
优先权日:2013-04-05
标题:Compounds Useful for the Treatment of Metabolic Disorders and Synthesis of the Same

专利号:US-2023271983-A1
优先权日:2020-07-29
标题 :Functionalized isonitriles and products, preparation and uses thereof
发明人：SOTELO PÉREZ EDDY; AZUAJE GUERRERO JHONNY ALBERTO; MAJELLARO MARIA
权利人:UNIV SANTIAGO COMPOSTELA
摘要:The present invention relates to functionalized isonitrile compounds, formed by means of multicomponent environmentally friendly reactions, suitable for coupling to functional molecules such as biomolecules, APIs, chromophore and fluorophore molecules. The invention also relates to conjugates between said isonitrile compounds and functional molecules, which are useful in the synthesis of pharmaceutic drugs or tools, fluorescent molecules and labels, polymeric smart materials. The invention furthermore provides a kit for the in-vitro preparation of the functionalized isontrile compounds and conjugates. The invention also contemplates the medical use of said compounds and conjugates.

专利号:US-2016046560-A1
优先权日:2013-04-05
标题 :Compounds useful for the treatment of metabolic disorders and synthesis of the same

专利号:CN-1051764-C
优先权日:1996-06-25
标题 :Stereoselective Synthesis of Enantiomerically Pure 3-Amino-1,2-Disubstituted Pyrrolidines

专利号:WO-2014165816-A1
优先权日:2013-04-05
标 题 :Compounds useful for the treatment of metabolic disorders and synthesis of the same