专利号:US-9403841-B2 优先权日:2012-01-25 标题:Phragamalin limonoids for the treatment of sexual dysfunction 发明人:WIKBERG JARL; JIRGENSONS AIGARS; LIEPINSH EDVARDS 权利人:DICOTYLEDON AB 摘要:The present invention relates to novel chemical compounds, to methods for synthesis of such compounds, and to the use of these novel compounds in the synthesis of other chemical compounds that, inter alia, may be used in the treatment of sexual dysfunction, and for eliciting enhancing effects on sexual behavior. The invention also relates to remarkable biological properties of the novel compounds in their capacity of inducing aggressive behavior.
专利号:WO-2016192694-A1 优先权日:2015-06-05 标 题 :A process for preparing the key intermediate of apremilast, using enzymatic resolution of the racemic amines 发明人:DOUBSKY JAN; KLVANA ROBERT; RICHTER JINDRICH; Lehnert Petr 权利人:ZENTIVA KS 摘要:The invention relates to a preparation method of (S)-l-(3-ethoxy-4-methoxyphenyl)- 2-(methylsulfonyl)-ethyl-amine (S)-l, or its N-acyl derivatives of general formula (S)-2. The amine (S)-l is the key intermediate in the synthesis of (S)-{2-[l-(3-ethoxy-4- methoxyphenyi)-2-methyisulfonylethyl]-4-acetylaminoisoindolin-l 3-dione, known as Apremilast. In this synthesis, the amine (S)-l, or its respective salts, are subjected to condensation with 3-acetamidophthalic anhydride 4, providing the desired product 3 (Scheme 1).
专利号:US-8759584-B2 优先权日:2007-12-14 标 题 :Synthesis of biguanidines and triazines, and biguanidino-aluminium complexes as intermediates 发明人:FORD MARK JAMES 权利人:FORD MARK JAMES; BAYER CROPSCIENCE AG 摘要:Compounds of formula (I) or salts thereof, n nin which R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , X and Y are defined as in claim 1 , can be prepared by a process characterized in that a compound of the formula (II) or a salt thereof,n n nis reacted to a compound of the formula (III) or a salt thereof,n n nand an aluminium(III) source, optionally, in the presence of a protic additive or solvent selected from the group consisting of alcohols or amines.n n The compounds (I) are suitable to be used for the preparation of heterocyclic compounds corresponding to (I) where the group Al(X)(Y) is replaced with an optionally substituted carbon atom, or s-triazine derivatives thereof.
专利号:US-8268936-B2 优先权日:2005-01-04 标题:Synthesis of hybrid block copolymers and uses thereof 发明人:BREITENKAMP KURT; SILL KEVIN N 权利人:BREITENKAMP KURT; SILL KEVIN N; INTEZYNE TECHNOLOGIES INC 摘要:The present invention relates to the field of polymer chemistry and more particularly to multiblock copolymers and methods of preparing the same.
专利号:US-2012196989-A1 优先权日:2005-02-11 标题:Synthesis of homopolymers and block copolymers 发明人:BREITENKAMP KURT; SILL KEVIN N 权利人:BREITENKAMP KURT; SILL KEVIN N; INTEZYNE TECHNOLOGIES INC 摘要:The present invention relates to the field of polymer chemistry and more particularly to homopolymers and block copolymers and methods of preparing the same.
专利号:US-7745626-B2 优先权日:2002-03-29 标 题 :Stereoselective alkylation of chiral 2-methyl-4-protected piperazines 发明人:WU WENXUE; LIAO HONGBIAO; TSAI DAVID J; ANDREWS DAVID R; GALA DINESH; LEE GARY M; SCHWARTZ MARTIN LAWRENCE; MCALLISTER TIMOTHY L; FU XIAOYONG; MALONEY DONAL; THIRUVENGADAM TIRUVETTIPURAM K; TANN CHOU-HANG 权利人:SCHERING CORP 摘要:In an illustrative embodiment, the present invention describes the synthesis of the following compound and similar compounds, in high stereochemical purity by a novel stereoselective alkylation process:
摘要:Shi, Y.; Cole-Hamilton, D. J.; Kamer, P. C. J., Science of Synthesis: Catalytic Reduction in Organic Synthesis, (2017) 2, 192. 摘要:Adriaensen, K.; De Vos, D., Science of Synthesis, (2022) , 150. 摘要:Adriaensen, K.; De Vos, D., Science of Synthesis, (2022) , 173.