CAS: 59937-28-9; Diisopropyl 2-(1,3-Dithiol-2-Ylidene)Malonate

该化合物是一种肝脏保护剂,主要用于治疗慢性肝脏疾病,包括肝硬化和肝炎,其行动机制包括促进肝细胞再生和增强蛋白合成,这有助于恢复肝功能.Malotilate还表现出了抗炎和抗纤维化特性,从而有效地减轻肝脏组织损伤.该化合物以其毒性低和有利的药用动因学为名,确保了最低的不良影响.它采取双重行动支持肝脏修复和减少纤维化,以此作为治疗肝脏病的有价值的治疗选择.临床研究显示,它对于改善肝脏酶水平和总体肝脏健康具有功效.

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上下游产品

Dipropan-2-Yl 2-[bis(Sulfanyl)Methylidene]Propanedioate 126164-80-5
4-Hydroxy-1,3-Dithiolan-2-Ylidenmalonsaeure-Diisopropylester 61839-12-1

合成工艺路线路线简述

    📜4-Hydroxy-1,3-Dithiolan-2-Ylidenmalonsaeure-Diisopropylester 反应生成 二噻茂醋
    参考文献:Taninaka,Kuniaki;Kurano,Xitosi;Kasai,Tsutomu
    标题:Taninaka,Kuniaki;Kurano,Xitosi;Kasai,Tsutomu

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    专利信息


    专利号:US-11241670-B2
    优先权日:2017-03-13
    标题 :Synthesis of a thin insoluble hydroxide shell on the surface of magnetic zero-valent metal nanoparticles for environmental remediation
    发明人:Li xiao yan; HU YI BO
    权利人:UNIV HONG KONG
    摘要:An insoluble thin hydroxide shell is synthesized on the surface of nanoscale zero-valent iron (NZVI), using a rate-controlled deprotonation method. The hydroxide coated NZVI remains suspended in aqueous phase better than the prior art and can be used to remove groundwater contaminants.

    专利号:US-11285169-B2
    优先权日:2013-03-13
    标题 :Methods for modulating chemotherapeutic cytotoxicity
    发明人:ROBERTS DAVID D; SOTO PANTOJA DAVID R
    权利人:US HEALTH
    摘要:Methods of reducing cytotoxicity of a chemotherapeutic agent to non-cancer cells by administering to a subject with cancer an effective amount of an agent that inhibits CD47 signaling and a DNA damaging agent, such as an anthracycline, topoisomerase inhibitor, or nucleotide synthesis inhibitor, are provided. Example disclosed methods reduce cardiotoxicity. In one example, the methods include administering to a subject with cancer an effective amount of a CD47 antisense morpholino oligonucleotide and an anthracycline such as doxorubicin. Methods of increasing cytotoxicity of a chemotherapeutic agent in cancer cells by administering to a subject with a tumor an effective amount of an agent that inhibits CD47 signaling and a DNA damaging agent such as an anthracycline, topoisomerase inhibitor, or nucleotide synthesis inhibitor, are also provided. In some embodiments, the inhibitor of CD47 signaling is administered to the subject before, during, or after the administration of the DNA damaging agent.

    专利号:US-2014315720-A1
    优先权日:2012-10-24
    标 题 :Polysaccharide ester microspheres and methods and articles relating thereto
    发明人:FALLON DENIS G; GARRETT THOMAS S; KIZER LAWTON E; ZAZZARA KAREN L; COMBS MICHAEL T; JOHNSON RICHARD K; DEHART GARY
    权利人:CELANESE ACETATE LLC
    摘要:A method for producing a polysaccharide ester microsphere may include forming a polysaccharide ester product from a polysaccharide synthesis, wherein the polysaccharide ester product comprises a polysaccharide ester and a solvent; diluting the polysaccharide ester product, thereby yielding a polysaccharide ester dope; and forming a plurality of polysaccharide ester microspheres from the polysaccharide ester dope. Suitable polysaccharides may include, but are not limited to, starch, cellulose, hemicellulose, algenates, chitosan, and any combination thereof. Esters thereof may be organic esters (e.g., acetate and the like), inorganic esters (e.g., sulfonates and the like), or combinations thereof. Further, the solids conent of the polysaccharide ester dope, in some instances, may be greater than about 16 wt %.

    专利号:US-6884842-B2
    优先权日:1997-10-14
    标题:Molecular compounds having complementary surfaces to targets
    发明人:SOANE DAVID S; BARRY STEPHEN E; GOODWIN ANDREW; OFFORD DAVID A; PERROTT MICHAEL G
    权利人:ALNIS BIOSCIENCES INC
    摘要:Synthetic polymer complements (SPCs) are provided, as well as methods for their synthesis and use. The SPCs may have surfaces that include functional groups that are complementary to surface sites of targets such as nanostructures or macromolecular targets, and may be capable of specifically interacting with such targets. The positions of the functional groups in one embodiment are stabilized by a polymer network. The SPCs are formed by contacting the target with a set of monomers which self-assemble on the target, and then are polymerized into a network to form the synthetic polymer complement. At least a portion of the surface of the resulting SPC thus may include an imprint of the target. The complex of the SPC and the target may be the desired product. Alternatively, the target is released, for example, by controllably expanding and contracting the crosslinked network. The SPC is isolated and used in many applications.

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    ✅ COA系统入驻 | 共享模式

    主要参考文献

    1. Zijlstra, F.J., Wilson, J.H., Vermeer, M.A., et al. Differential effects of malotilate on 5-, 12- and 15-lipoxygenase in human ascites cells. Eur. J. Pharmacol. 159(3), 291-295 (1989). 2. Nokata, M., Katoh, M., and Sugimoto, T. Protective effect of malotilate (Diisopropyl 1,3-dithiol-2-ylidenemalonate) on carbon tetrachloride-induced liver injury in mice and rats. J. Toxicol. Sci. 10(4), 279-288 (1985). 3. Ryhanen, L., Stenback, F., Ala-Kokko, L., et al. The effect of malotilate on type III and type IV collagen, laminin and fibronectin metabolism in dimethylnitrosamine-induced liver fibrosis in the rat. J. Hepatol. 24(2), 238-245 (1996).

    合成参考文献


    摘要:Toho Igakkai Zasshi. Journal of Medical Society of Toho University., 25(387), 1978
    参考文献:10.2165/00063030-200115070-00005
    摘要:Wellington K, Jarvis B. Silymarin: a review of its clinical properties in the management of hepatic disorders. BioDrugs. 2001;15(7):465–89. doi: 10.2165/00063030-200115070-00005.
    参考文献:10.1007/bf02975101
    摘要:Nan JX, Park EJ, Yang BK, Song CH, Ko G, Sohn DH. Antifibrotic effect of extracellular biopolymer from submerged mycelial cultures of Cordyceps militaris on liver fibrosis induced by bile duct ligation and scission in rats. Arch Pharm Res. 2001 Aug;24(4):327–32. doi: 10.1007/bf02975101.
    参考文献:10.1016/s0022-3565(25)24922-9
    摘要:Itakura M, Tsuchiya M, Yamashita K, Oda T. Malotilate (diisopropyl 1,3-dithiol-2-ylidenemalonate) increases liver de novo purine synthesis and amidophosphoribosyltransferase activity. The Journal of Pharmacology and Experimental Therapeutics. 1986 Jun;237(3):794–8. doi: 10.1016/s0022-3565(25)24922-9.
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