CAS: 537013-51-7; 4-Bromo-2,6-Difluorobenzaldehyde

上下游产品

CAS号461-96-1 1-溴-3,5-二氟苯 | CAS号68-12-2 N,N-二甲基甲酰胺 | CAS号162744-59-4 4-溴-2,6-二氟苯甲醇 | CAS号2591-86-8 1-甲酰哌啶 | CAS号885519-21-1 顺式-八氢-2-甲基-吡咯并[... | CAS号183065-68-1 4-溴-2,6-二氟苯甲酸

1-溴-3,5-二氟苯置于lithium Diisopropyl Amide体系中,用 四氢呋喃,N,N-二甲基甲酰胺 作为反应溶剂,化学反应 5.5H,以68%的收率获得产物4-溴-2,6-二氟苯甲醛
参考文献:一种三取代嘧啶衍生物对蛋白激酶的抑制作用
标题:一种三取代嘧啶衍生物对蛋白激酶的抑制作用
摘要:本发明公开了一种三取代嘧啶衍生物,具有通式(ⅰ)结构,其药学上可接受的盐,酯或溶剂化合物,所述衍生物为蛋白激酶抑制剂,可单独或与其它药物联用,用于癌症的治疗,具有巨大的临床应用价值.通式(ⅰ).

专利信息

专利号:US-8350100-B2
优先权日:2002-03-15
标题 :Process for the preparation of ring compounds
发明人：PAULUTH DETLEF; KIRSCH PEER; BAEUERLE PETER; DEEG OLIVER
权利人:MERCK PATENT GMBH; PAULUTH DETLEF; KIRSCH PEER; BAEUERLE PETER; DEEG OLIVER
摘要:In a process for the preparation of ring compounds via a combinatorial synthesis, the reaction procedure is based on a Suzuki coupling; subsequent halo-demetallation and finally a further Suzuki coupling. The Suzuki couplings are each carried out with a boronic acid or a boronic acid ester. The reaction procedure uses provides novel ring compounds and uses novel synthesis units used for this purpose. The novel ring compounds are suitable for use as constituents in liquid-crystalline mixtures.

专利号:US-11780834-B2
优先权日:2018-06-21
标题:Solid forms of 3-((1R,3R)-1-(2,6-difluoro-4-((1-(3-fluoropropyl)azetidin-3- yl)amino)phenyl)-3-methyl-1,3,4,9-tetrahydro-2H-pyrido[3,4-b]indol-2-yl)-2,2-difluoropropan-1-ol and processes for preparing fused tricyclic compounds comprising a substituted phenyl or pyridinyl moiety, including methods of their use
发明人：CHUNG CHEOL KEUN; XU JIE; IDING HANS; CLAGG KYLE; DALZIEL MICHAEL; FETTES ALEC; GOSSELIN FRANCIS; LIM NGIAP-KIE; MCCLORY ANDREW; ZHANG HAIMING; CHAKRAVARTY PAROMA; NAGAPUDI KARTHIK; ROBINSON SARAH
权利人:HOFFMANN LA ROCHE; GENENTECH INC
摘要:Provided herein are solid forms, salts, and formulations of 3-((1R,3R)-1-(2,6-difluoro-4-((1-(3-fluoropropyl)azetidin-3-yl)amino)phenyl)-3-methyl-1,3,4,9-tetrahydro-2H-pyrido[3,4-b]indol-2-yl)-2,2-difluoropropan-1-ol, processes and synthesis thereof, and methods of their use in the treatment of cancer.

专利号:US-9708278-B2
优先权日:2013-11-27
标 题 :Substituted 4-benzyl-3,4-dihydro-2H-benzo[B][1,4]oxazine-2-carboxamide analogs as positive allosteric modulators of muscarinic acetycholine receptor M1
发明人：LINDSLEY CRAIG W; CONN P JEFFREY; STAUFFER SHAUN R; PANARESE JOSEPH D
权利人:UNIV VANDERBILT
摘要:In one aspect, the invention relates to N-substituted 3,4-dihydro-benzo[£][1,4]oxazine-2-carboxamide analogs, derivatives thereof, and related compounds, which are useful as positive allosteric modulators of the muscarinic acetylcholine receptor M 1 (mAChR M 1 ); synthesis methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating neurological and psychiatric disorders associated with muscarinic acetylcholine receptor dysfunction using the compounds and compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

专利号:CN-114790174-A
优先权日:2022-04-14
标题 :A kind of method for continuous synthesis of 1H-indazole compounds

专利号:CN-117700459-B
优先权日:2023-12-25
标题 :Synthesis and application of a type of benzo five-membered C-P ring skeleton monophosphine ligand

专利号:CN-117700459-A
优先权日:2023-12-25
标 题:Synthesis method and application of a type of benzo five-membered C-P ring skeleton monophosphine ligand