CAS: 5306-98-9; 5-Chloro-2-Methylphenol

该化合物是一种属于氯化酚类的有机化合物,其特征为带有氯原子的酚状结构,与芳香环相连的甲基组别,该化合物一般为白色至浅黄色固体,有明显的气味,在水中略有溶解,但在有机溶剂中较易溶解,反映其疏水性质. 5-Croloo-2-甲基酚具有抗微生物特性,在各种应用中有用,包括在化妆品和个人护理产品中用作防腐剂,以及在工业环境中用于其生物杀菌效果.该化合物的再活性受氯和甲基亚成分的存在影响,这些成分可参与电药性芳香替代反应.在处理该物质时,安全考虑十分重要,因为如果摄入或吸入,可能会对健康造成危害,因此应当采取适当的预防措施,以尽量减少接触.

结构式图片

欧盟法规

ECHA物质ECHA物质C&L通报REACH预注册

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CAS号95-79-4 5-氯-2-甲基苯胺 | CAS号89-59-8 4-氯-2-硝基甲苯 | CAS号75508-74-6 5-chloro-2-meth... | CAS号106-43-4 对氯甲苯 | CAS号27139-97-5 2-溴-4-氯甲苯 | CAS号95-73-8 2,4-二氯甲苯 | CAS号86297-37-2 acetic acid,5-c... | CAS号124-41-4 甲醇钠 | CAS号40794-04-5 5-氯-2-甲基苯甲醚 | CAS号32281-01-9 4-羟基-3-甲基苯硫酚 | CAS号2420-26-0 4-氯水杨醛 | CAS号19832-87-2 2-氯-5-甲基-1,4-苯醌 | CAS号3569-84-4 1-[2-(diethylam... | CAS号3569-85-5 1-[2-(diethylam... | CAS号551-78-0 4,5,6-trichloro... | CAS号53581-86-5 4-氯-2-甲氧基苯甲醛

合成工艺路线路线简述

    4-氯-2-硝基甲苯置于甲醇,硫酸,镍体系中,60.0 °C,13.73 Mpa 条件下,反应生成 5-氯-2-甲基苯酚
    参考文献:The Gattermann Reaction In The Mono-Methoxydiphenyl Ethers1
    标题:The Gattermann Reaction In The Mono-Methoxydiphenyl Ethers1
    摘要:
    DOI:10.1021/ja01249A024

    海关参考信息

    专利信息


    专利号:US-2009247618-A1
    优先权日:2008-03-26
    标题 :Process for preparation of benzo-fused heteroaryl derivatives
    发明人:BALLENTINE SCOTT A; REANY LAURA
    权利人:BALLENTINE SCOTT A; REANY LAURA
    摘要:The present invention is directed to processes for the preparation of benzo-fused heteroaryl derivatives, useful for the treatment of epilepsy and related disorders. The present invention is further directed to processes for the preparation of intermediates in the synthesis of the benzo-fused heteroaryl derivatives.

    专利号:US-8106031-B2
    优先权日:2006-05-02
    标题:Hydrolytically-resistant boron-containing therapeutics and methods of use
    发明人:LEE VING; PLATTNER JACOB J; BENKOVIC STEPHEN J; BAKER STEPHEN J; MAPLES KIRK R; BELLINGER-KAWAHARA CAROLYN; AKAMA TSUTOMU; ZHANG YONG-KANG; SINGH RAJESHWAR; SAURO VITTORIO A
    权利人:LEE VING; PLATTNER JACOB J; BENKOVIC STEPHEN J; BAKER STEPHEN J; MAPLES KIRK R; BELLINGER-KAWAHARA CAROLYN; AKAMA TSUTOMU; ZHANG YONG-KANG; SINGH RAJESHWAR; SAURO VITTORIO A; ANACOR PHARMACEUTICALS INC
    摘要:Compositions and methods of use of boron derivatives, including benzoxaboroles, benzazaboroles and benzthiaboroles, as therapeutic agents for treatment of diseases caused by fungi, yeast, bacteria or viruses are disclosed, as well as methods for synthesis of said agents and compositions thereof.

    专利号:US-4161609-A
    优先权日:1977-09-14
    标题:Synthesis of carboxylic acid esters
    发明人:CRAMER RICHARD D
    权利人:DU PONT
    摘要:A method is provided for converting a carboxylic acid amide to a carboxylic acid ester by reacting a vaporized mixture of the amide and an aliphatic alcohol or a phenol in the presence of a suitable catalyst at temperatures of from 100 DEG C. to 400 DEG C. The process is especially useful for the conversion of methacrylamide to methyl methacrylate.

    专利号:US-4797427-A
    优先权日:1987-04-25
    标题:Aromatic diamines containing sulfonic acid aryl esters, a process for their production and their use in the production of polyurethane plastics
    发明人:SANDERS JOSEF; REIFF HELMUT; BALLE GERHARD; DIETERICH DIETER
    权利人:BAYER AG
    摘要:The present invention is directed to new aromatic diamines containing sulfonic acid aryl esters corresponding to the formula wherein R1 represents hydrogen, an optionally branched C1-C6 alkyl radical (preferably a methyl group), a C1-C6 alkoxy radical or a halogen atom (preferably chlorine) and R2 and R3 which may be the same or different, represent hydrogen, an optionally branched C1-C20 (preferably C1-C6) alkyl radical, a C1-C6 alkoxy radical or a halogen atom (preferably chlorine). The present invention is also directed to a process for the production of the above aromatic diamines containing sulfonic acid esters by the reaction of optionally substituted sulfochlorides with optionally substituted phenols followed by hydrogenation. Finally, the present invention is directed to the use of aromatic diamines containing sulfonic acid aryl esters as a synthesis component for the production of polyurethane plastics by the isocyanate polyaddition process.

    专利号:US-4540834-A
    优先权日:1983-03-02
    标 题:Process for the preparation of metachlorophenols
    发明人:CORDIER GEORGES
    权利人:RHONE POULENC SPEC CHIM
    摘要:The invention relates to a process for the preparation of metachlorophenols. The process consists in selectively hydrodechlorinating, under the action of heat and in the liquid phase, polychlorophenols containing at least one chlorine atom in the meta position relative to the phenolic hydroxyl, by reacting these polychlorophenols with hydriodic acid in a quantity which is sufficient in relation to the chlorine atoms to be removed. The metachlorophenols obtained are organic synthesis intermediates.

    专利号:EP-0055196-A1
    优先权日:1980-12-24
    标题:Process for the synthesis of metachlorophenols
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    合成参考文献


    参考文献:10.5281/zenodo.3827487
    摘要:USEPA/Office of Pesticides and Toxic Substances; Simazine: Revised Preliminary HED Chapter of the Reregistration Eligibility Decision Document (RED), Document ID: EPA-HQ-OPP-2005-0151-0023 p.17-18 (May 31, 2005). Available from, as of June 6, 2007: http://www.regulations.gov/fdmspublic/component/main
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