CAS: 380381-28-2; Methyl 4-Iodopicolinate

该化合物是一种多元的热循环结构,广泛用于制药和农用化学合成.该化合物的特点是4点和甲基酯组以碘原子替代了4点和甲基原子,增强了其在诸如铃木-宫浦或斯蒂尔等交叉反应中的回动性.它的高度纯度和稳定性使它成为建造复杂分子结构的可靠中间体.碘碱为进一步功能化提供了极好的选择性,而酯组则提供了额外的衍生机会.该化合物由于其可预见的回活动性和与多种合成条件的兼容性,在药用化学中对于生物活性分子的发展特别宝贵.

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405939-79-9 112776-84-8 41960-44-5

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CAS号67-56-1 甲醇 | CAS号405939-79-9 4-碘吡啶-2-羧酸 | CAS号24484-93-3 4-氯吡啶-2-甲酸甲酯 | CAS号98-98-6 2-吡啶甲酸 | CAS号5470-22-4 4-氯-2-吡啶甲酸

合成工艺路线路线简述

    4-氯吡啶-2-甲酸甲酯置于硫酸,氢碘酸,次磷酸体系中,化学反应 49.0H,反应生成 4-碘吡啶-2-甲酸甲酯
    参考文献:Allosteric Modulators Of 5-Hydroxytryptamine 2C Receptor (5-Ht2Cr)
    标题:Allosteric Modulators Of 5-Hydroxytryptamine 2C Receptor (5-Ht2Cr)
    摘要:该披露涉及被确定为5-Ht 2Cr的别构调节剂的化合物,以及使用这些化合物的药物组合物和方法.某些实施例还包括鉴定方法和合成这些化合物的方法.优化和开发结合非主要配体结合位点的别构5-Ht 2Cr调节剂,可反应生成新颖,高选择性和高效的5-Ht2Cr配体.这些分子可以用作神经系统的小分子探针,也可以作为多种疾病的有效治疗药物.

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    专利信息


    专利号:US-7199105-B2
    优先权日:2002-08-15
    标 题:Lincomycin derivatives possessing antibacterial activity
    发明人:LEWIS JASON G; PATEL DINESH V; ANANDAN SAMPATH KUMAR; GORDEEV MIKHAIL F
    权利人:VICURON PHARM INC
    摘要:Novel lincomycin derivatives are disclosed. These lincomycin derivatives exhibit antibacterial activity. As the compounds of the subject invention exhibit potent activities against bacteria, including gram positive organisms, they are useful antimicrobial agents. Methods of synthesis and of use of the compounds are also disclosed.

    专利号:US-7164011-B2
    优先权日:2002-08-15
    标题:Lincomycin derivatives possessing antibacterial activity
    发明人:LEWIS JASON; PATEL DINESH V; ANANDAN SAMPATH K; GORDEEV MIKHAIL F
    权利人:VICURON PHARM INC
    摘要:Novel lincomycin derivatives are disclosed. These lincomycin derivatives exhibit antibacterial activity. As the compounds of the subject invention exhibit potent activities against bacteria, including gram positive organisms, they are useful antimicrobial agents. Methods of synthesis and of use of the compounds are also disclosed.

    专利号:US-7256177-B2
    优先权日:2003-06-17
    标题 :Lincomycin derivatives possessing antibacterial activity
    发明人:LEWIS JASON G; ANANDAN SAMPATH K; O'DOWD HARDWIN; GORDEEV MIKHAIL F
    权利人:VICURON PHARM INC
    摘要:Novel lincomycin derivatives are disclosed. These lincomycin derivatives exhibit antibacterial activity. The compounds of the subject invention may exhibit potent activities against bacteria, including Gram positive organisms, and may be useful antimicrobial agents. Methods of synthesis and of use of the compounds are also disclosed.

    专利号:US-7361743-B2
    优先权日:2004-02-11
    标 题 :Lincomycin derivatives possessing antibacterial activity
    发明人:LEWIS JASON G; ANANDAN SAMPATH K; O'DOWD HARDWIN; GORDEEV MIKHAIL F; LI LIANSHENG
    权利人:PFIZER
    摘要:Novel lincomycin derivatives are disclosed. These lincomycin derivatives exhibit antibacterial activity. The compounds of the subject invention may exhibit potent activities against bacteria, including Gram positive organisms, and may be useful antimicrobial agents. Methods of synthesis and of use of the compounds are also disclosed.

    专利号:US-7199106-B2
    优先权日:2003-06-17
    标题 :Lincomycin derivatives possessing antimicrobial activity
    发明人:LEWIS JASON G; ANANDAN SAMPATH-KUMAR; O'DOWD HARDWIN; GORDEEV MIKHAIL F
    权利人:VICURON PHARM INC
    摘要:Novel lincomycin derivatives are disclosed. These lincomycin derivatives exhibit antibacterial activity. The compounds of the subject invention may exhibit potent activities against bacteria, including gram positive organisms, and may be useful antimicrobial agents. Methods of synthesis and of use of the compounds are also disclosed.
    武汉弘德悦欣医药科技有限公司
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    4-碘吡啶-2-甲酸甲酯
    Methyl 4-iodopicolinate
    产品图片纯度:98
    250kg/drum
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