CAS: 37553-65-4; Boc-N-Me-Phe-Oh

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叔丁氧羰酰基肌氨酸置于n-甲基吗啉,六甲基磷酰三胺,Lithium Hydroxide,正丁基锂,四丁基溴化铵,Lithium Bromide,氯甲酸异丁酯体系中,用 乙二醇二甲醚,乙腈 作为反应溶剂,化学反应 1.08H,反应生成 Boc-N-甲基-L-苯丙氨酸
参考文献:Asymmetric Synthesis Of Boc-N-Methyl-P-Benzoyl-Phenylalanine. Preparation Of A Photoreactive Antagonist Of Substance P
标题:Asymmetric Synthesis Of Boc-N-Methyl-P-Benzoyl-Phenylalanine. Preparation Of A Photoreactive Antagonist Of Substance P
摘要:The Asymmetric Synthesis Of (S)-Boc-N-Methyl-P-Benzoyl-Phenylalanine Was Performed By Alkylation Of Sultam Boc-Sarcosinate. The Levorotatory Sultam Led To (S)-Boc-N-Methyl Amino Acids With High Optical Purity. This Photoreactive Amino Acid Was Incorporated Into The Sequence Of A Substance P Peptide Antagonist. Comparison Of The Affinity And Antagonistic Properties Of Biotinyl-Apa-[d-Pro(9),Mephe(Pbz)(10),Trp(11)]Sp For Human Tachykinin Nk-1 Receptor Demonstrated That This Photoreactive Antagonist Should Be A Suitable Tool For Photolabelling Studies,(C) 1998 Elsevier Science Ltd. All Rights Reserved.
DOI:10.1016/s0960-894X(98)00219-4