CAS: 33755-53-2; 4-Nitrophenyl 5-((3As,4S,6Ar)-2-Oxohexahydro-1H-Thieno[3,4-D]Imidazol-4-yl)Pentanoate

该化合物是一种生物基状活性酯衍生物,通常用作蛋白质,和核酸等生物分子的标签试剂.该化合物的特性是p-硝基苯酯酯组,该组在温和条件下促进与初级氨的高效结合,产生稳定的氨化结.其生物基质的粘合性使粘合性与streptavidin或avidin具有很强的亲近性,因此对亲近性染色学,免疫测定和蛋白检测的应用很有价值.该(+)抗生素确保了对乳腺敏感的系统具有高度的特性.关键优点包括高反应性,缓冲兼容性水溶性以及生物鉴定中最小的干扰.该试剂对于需要目标分子精确和稳定的生物关联的研究人员特别有用.

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901770-40-9 120550-35-8 58-85-5

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上下游产品

D-生物素 Biotin 58-85-5

合成工艺路线路线简述

    📜5-((3As)-2-Oxo-1-Trifluoroacetyl-(3Ar,6Ac)-Hexahydro-Thieno[3,4-D]Imidazol-4T-yl)-Pentanoic Acid 4-Nitro-Phenyl Ester置于乙醇体系中,化学反应生成(+)-生物素 4-硝基苯酯
    参考文献:含生物胞素的肽的合成.
    标题:含生物胞素的肽的合成.
    摘要:
    Doi:10.1021/ja00443A040

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    专利信息


    专利号:US-6277489-B1
    优先权日:1998-12-04
    标题:Support for high performance affinity chromatography and other uses
    发明人：ABBOTT NICHOLAS; STROEVE PIETER; DUBROVSKY TIMOTHY B; HOU ZHIZHONG
    权利人:UNIV CALIFORNIA
    摘要:Multilayered particulate materials are formed by coating a particulate substrate with a metal and adsorbing an organic layer comprising a recognition moiety onto the metal film. The recognition moiety interacts with an analyte of interest allowing for its detection, purification, etc. Suitable recognition moieties can be selected from a range of species including, small molecules, polymers and biomolecules and the like. The novel particulate materials of the invention can be utilized in an array of methods including, ion-exchange, ion-selective ion-exchange, assays, affinity dialysis, size exclusion dialysis, as supports in solid phase synthesis, combinatorial synthesis and screening of compound libraries and the like.

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    主要参考文献

    [参考文献]: An S, Et Al. Small-Molecule Protacs: An Emerging And Promising Approach For The Development Of Targeted Therapy Drugs. Ebiomedicine. 2018 Oct;36:553-562

    合成参考文献


    参考文献:10.1016/j.jasms.2008.02.004
    摘要:Jalili PR, Ball HL. Novel reversible biotinylated probe for the selective enrichment of phosphorylated peptides from complex mixtures. Journal of The American Society for Mass Spectrometry. 2008 May;19(5):741–50. doi: 10.1016/j.jasms.2008.02.004.
    参考文献:10.1007/978-1-61779-148-2_16
    摘要:Timmer JC, Salvesen GS. N-terminomics: a high-content screen for protease substrates and their cleavage sites. Methods Mol Biol. 2011;753():243–55. doi: 10.1007/978-1-61779-148-2_16.
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