CAS: 27784-76-5; Tert-Butyl 2-(Diethoxyphosphoryl)Acetate

相似化合物

3095-95-2 867-13-0 867-13-0

上下游产品

acetic acid tert-butyl ester diethyl chlorophosphate tert-Butyl chloroacetate phosphonic acid diethyl esterdiethylphosphonoacetic acid (E)-3-((2R,3S,4R)-3,4-Bis-benzyloxy-3,4-dihydro-2H-pyran-2-yl)-acrylic acid tert-butyl ester (2E,6Z)-(S)-4-(4-Methoxy-benzyloxy)-undeca-2,6-dienedioic acid 1-tert-butyl ester 11-methyl ester -(E)-propenoatetert-butyl (S)-3-2,2-dimethyl-3-(phenylthioacetyl)oxazolidin-4-yl-(E)-propenoate

溴乙酸叔丁酯,亚磷酸三乙酯 以 Neat (No Solvent) 用作溶剂,化学反应 24.0H,反应生成二乙基膦酰基乙酸叔丁酯
参考文献:旋光性烯烃的不对称二羟基化中的双重立体变位
标题:旋光性烯烃的不对称二羟基化中的双重立体变位
摘要:进行了对光学活性乙烯基环氧化物及其衍生物(溴衍生物,叠氮基衍生物和乙烯基氮丙啶)的双键的不对称二羟基化的立体化学控制的研究,并在此报道了获得的结果.反式α,β-不饱和环氧酯获得了最有趣的结果,根据匹配的或不匹配的条件,根据使用的配体,非对映体比例> 80%的非对映体成功地将其转化为相应的二醇.未保护的溴代衍生物和未保护的氮丙啶没有显着结果,而对于受保护的溴衍生物,叠氮基衍生物和n-Boc保护的氮丙啶,匹配条件导致非对映异构体比率> 95%.手性28:387-393,2016.©2016 Wiley Periodicals,Inc.
Doi:10.1002/chir.22587

专利信息

专利号:US-9242965-B2
优先权日:2013-12-31
标题:Process for the manufacture of (E)-4-N,N-dialkylamino crotonic acid in HX salt form and use thereof for synthesis of EGFR tyrosine kinase inhibitors
发明人：ZHENG JUNCHENG; DENG DA; LV GUANGHUA; YAN JUN; BRANDENBURG JOERG; KROEBER JUTTA; SCHOLZ ULRICH
权利人:BOEHRINGER INGELHEIM INT
摘要:The present invention is directed to an efficient process for the manufacture of (E)-4-N,N-dialkylamino crotonic acid in HX salt form of formula I n nwherein R 1 and R 2 independently denote C 1-3 -alkyl groups and X − denotes an acid anion, such as the chloride, bromide, tosylate, mesylate or trifluoroacetate anion, with high quality, and a process for synthesis of EGFR tyrosine kinase inhibitors with heterocyclic quinazoline, quinoline or pyrimidopyrimidine core structure, using the acid addition salt I and activated derivatives thereof as intermediates.

专利号:EP-3089961-B1
优先权日:2013-12-31
标 题:Process for the manufacture of (e)-4-n,n-dialkylamino crotonic acid in hx salt form and use thereof for synthesis of egfr tyrosine kinase inhibitors

专利号:EP-3089961-A1
优先权日:2013-12-31
标题 :Process for the manufacture of (e)-4-n,n-dialkylamino crotonic acid in hx salt form and use thereof for synthesis of egfr tyrosine kinase inhibitors

专利号:US-2015183764-A1
优先权日:2013-12-31
标 题 :Process for the manufacture of (e)-4-n,n-dialkylamino crotonic acid in hx salt form and use thereof for synthesis of egfr tyrosine kinase inhibitors

专利号:US-6514997-B2
优先权日:1999-12-03
标题:Antipicornaviral compounds and compositions, their pharmaceutical uses, and materials for their synthesis
发明人：DRAGOVICH PETER S; PRINS THOMAS J; ZHOU RU; JOHNNSON JR THEODORE O
权利人:AGOURON PHARMA
摘要:Compounds of the formula: n where the formula variables are as defined herein, are disclosed that advantageously inhibit or block the biological activity of the picornaviral 3C protease. Also disclosed are compounds of the formula: n where the formula variables are as defined herein that advantageously inhibit or block the biological activity of the picornaviral 3C protease. These compounds, as well as pharmaceutical compositions containing these compounds, are useful for treating patients or hosts infected with one or more picornaviruses, such as rhinovirus 3C proteases. Intermediates and synthetic methods for preparing such compounds are also described.

专利号:US-2025206703-A1
优先权日:2022-04-01
标题:Process for preparing ((1s,2s)-2-(5-methylpyridin-2-yl)cyclopropyl)methanol
发明人：ARREDONDO JUAN D; CAO YANG; CHUNG JOHN Y L; LI HONGMEI
权利人:MERCK SHARP & DOHME LLC
摘要:Described is an efficient, scalable synthesis of compounds such as ((1S,2S)-2-(5-methylpyridin-2-yl)cyclo-propyl)m ethanol, which contains a disubstituted cyclopropane with two stereogenic centers and represents a significant challenging synthetic target.