CAS: 208255-80-5; Tert-Butyl (S)-2-((S)-2-(2-(3,5-Difluorophenyl)Acetamido)Propanamido)-2-Phenylacetate

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CAS号105184-38-1 3,5-二氟苯乙酸 | CAS号327052-53-9 N-(L-alanyl)-(2... | CAS号860013-16-7 N-(N-carbobenzy... | CAS号2935-35-5 (|S|)-(+)-α-苯甘氨酸 | CAS号53934-78-4 L-苯甘氨酸叔丁酯

📜L-苯甘氨酸置于palladium On Activated Charcoal 高氯酸,Wscd*hcl,氢气,1-羟基苯并三唑,三乙胺,N,N'-二环己基碳二亚胺体系中,用 甲醇,二氯甲烷 用作溶剂,化学反应生成(2S)-N-[n-(3,5-二氟苯乙酰基)-L-丙氨酰]-2-苯基甘氨酸叔丁酯
参考文献:Parallel Synthesis Of Dapt Derivatives And Their γ-Secretase-Inhibitory Activity
标题:Parallel Synthesis Of Dapt Derivatives And Their γ-Secretase-Inhibitory Activity
摘要:Parallel Synthesis Of The C-Terminal-Modified Dapt (1) Derivatives Was Accomplished Utilizing Our Novel Resin 7. Condensation Reaction Of The N-Acylamino Acid 10 With The Amines 11A-O Proceeded Smoothly To Give The Corresponding Amides 6A-O Without Any Epimerization. Among The Analogues,The Benzophenonemethyl Amide Derivative 6O Showed 30 Times More Potent Activity Than The Original Dapt (1). (C) 2004 Elsevier Ltd. All Rights Reserved.
Doi:10.1016/j.Bmcl.2004.01.067

专利信息

专利号:US-9458471-B2
优先权日:2006-11-03
标题 :Engineered cellular pathways for programmed autoregulation of differentiation
发明人：WEISS RON; LEMISCHKA IHOR; PURNICK PRISCILLA; SCHANIEL CHRISTOPH; MILLER MILES; GUYE PATRICK
权利人:UNIV PRINCETON
摘要:The present invention provides compositions and methods for programming mammalian cells to perform desired functions. In particular, the present invention provides compositions and methods for programming stem cells to differentiate into a desired cell type. A quorum sensing systems that regulates the expression of cell fate regulators is introduced into mammalian host cells, such as stem cells. The quorum sensing systems generally comprises vectors that express the components of a bacterial quorum sensing pathway, including proteins which catalyze the synthesis of an autoinducer and a gene encoding a regulatory partner of the autoinducer, and vectors in which genes encoding cell fate regulators are operably linked to a promoter induced by the autoinducer/regulatory partner complex. The system can also comprise vectors in which genes encoding additional cell fate regulators are operably linked to a promoter that is induced by a factor synthesized in response to a first stage of differentiation, so that a second stage of differentiation is triggered.

专利号:US-2025223262-A1
优先权日:2022-03-31
标 题 :Synthesis of morphinans with reduced herg activity and mop binding
发明人：LAMMERT ECKHARD; SCHOLZ OKKA; OTTER SILKE; HEREBIAN DIRAN; HOFFMANN TORSTEN; SANZ MIGUEL ANGEL; KRAMP LAURENZ; LEVY LAURA MARIANA; HRISTEVA STANIMIRA
权利人:HEINRICH HEINE UNIV DUESSELDORF; DEUTSCHE DIABETES FORSCHUNGSGESELLSCHAFT E V; TAROS CHEMICALS GMBH & CO KG
摘要:The invention relates to morphinan-derivatives, processes for their preparation, medicaments containing them and the use of these morphinan-derivatives for the preparation of medicaments.

专利号:US-2025206706-A1
优先权日:2022-03-21
标 题 :A method of producing explosive hmx by flow synethesis
发明人：DIDSBURY MATTHEW PAUL; MCWHIR NIALL JOHN; JUBB DANIEL; KENNEDY STUART ROBERT; KENNEDY NICOLA; JONES CHRISTOPHER; MURRAY IAN EWART PATERSON
权利人:BAE SYSTEMS PLC
摘要:The following invention relates to methods of producing explosives from the nitration of TAT by flow synthesis. The invention relates to a method for the flow synthesis manufacture of HMX, (1,3,5,7-tetranitro-1,3,5,7-tetraazacyclooctane), comprising the steps ofn i. preparing input flow admixture, comprising TAT (1, 3, 5, 7-tetraacetyl-1, 3, 5, 7-tetrazacyclooctane), P 2 O 5 , in nitric acid wherein the nitric acid concentration is greater than 95%, ii. causing the input flow reagent to enter a flow reactor, iii. heating the reaction chamber in the flow reactor in the range of 60° C. to 80° C., collecting the reacted admixture.

专利号:US-10682335-B2
优先权日:2014-07-28
标题 :Use of butylidenephthalide (Bdph), method of using the same, and method for preparing pharmaceutical composition containing the same
发明人：SU HONG-LIN; CHANG CHIA-YU; HWANG SHIAW-MIN; Lu huai-en; HARN HORNG-JYH; LIN SHINN-ZONG; LAI PING-SHAN
权利人:EVERFRONT BIOTECH INC
摘要:The present invention discloses use of butylidenephthalide (Bdph), a method of using the same, and a method for preparing a pharmaceutical composition containing the same. Because Bdph has the capability of promoting the hair growth and reducing the β-amyloid protein (Aβ) level in nerve cells, the efficacy of improving the health and appearance of a subject can be achieved by administrating an effective amount of Bdph to the subject. Specifically, the Bdph has the efficacy of preventing or treating neurodegenerative diseases such as Alzheimer's disease caused by excessive build up of Aβ in the cells, and as an active ingredient in a topical composition, the Bdph is effective in promoting the hair growth at the site where the Bdph is administered. Furthermore, the method for preparing a pharmaceutical composition containing Bdph comprises preparing the pharmaceutical composition through an organic synthesis reaction, wherein the Bdph is coated with a polymeric material such as F127 by covalent bonding of the polymeric material with the Bdph, thereby achieving the effect of reducing the cytotoxicity of the pharmaceutical composition for an organism.

专利号:EP-4499223-A1
优先权日:2022-03-31
标 题 :Synthesis of morphinans with reduced herg activity and mop binding

专利号:WO-2023187099-A1
优先权日:2022-03-31
标 题 :Synthesis of morphinans with reduced herg activity and mop binding