📜1-苄基-3,5-二甲基哌啶-4-酮置于platinum On Activated Charcoal,乙醚体系中,化学反应生成3,4,5-三甲基吡啶 参考文献:Vaculik; Kuthan,Collection Of Czechoslovak Chemical Communications,1959,Vol. 24,P. 174,176 标题:Vaculik; Kuthan,Collection Of Czechoslovak Chemical Communications,1959,Vol. 24,P. 174,176
专利号:US-5623068-A 优先权日:1994-03-07 标 题:Synthesis of DNA using substituted phenylacetyl-protected nucleotides 发明人:REDDY M PARAMESWARA; FAROOQUI FIRDOUS; HANNA NAEEM B 权利人:BECKMAN INSTRUMENTS INC 摘要:Deoxyribonucleotide and ribonucleotide derivatives of the general formula I I wherein R1 represents -CR'R''-Ar, in which Ar is substituted aryl (as hereinafter defined) and R' and R'' are independently selected from the group consisting of hydrogen and lower alkyl; one of -R2 and R3 is a hydroxyl-protecting group and the other is a group suitable for synthesis of polynucleotides or for attachment of the nucleotide to a solid support; R4 is selected from the group consisting of hydrogen, -OH and protected hydroxyl; and B represents a divalent radical corresponding to a purine or pyrimidine base. When synthesis is carried out using these derivatives, the deprotection procedure is reduced to an essentially instantaneous process. The derivatives have acceptable shelf life and are very stable to conventional DNA synthesis conditions. Particularly preferred are those compounds wherein Ar is mono- and dihalo-substituted phenyl.
专利号:US-6121454-A 优先权日:1997-05-06 标题 :Synthesis of pharmaceutically useful pyridine derivatives 发明人:ZOGHBI MICHEL; CHEN LIQUIN 权利人:PDI RESEARCH LAB INC 摘要:A process is provided for the preparation of compounds of formula I, useful in the preparation of compounds such as Omeprazole, Lansoprazole and Pantoprazole, wherein R1=H or CH3, R2=H or CH3, R3=Alkoxy (1-4C), OCH2CF3, Cyano, Hydrogen, Halogen, Acetoxy or Aryloxy, any electron withdrawing group or salts (organic or inorganic) of electron donating groups, R=Alkoxy, Hydroxy, Halogen, Activated ester, Tosylate, Mesylate, Thiol or Xanthyl, wherein the process for the preparation of compound of formula I employs a free radical reaction to functionalize the 2-position.
专利号:US-11117893-B2 优先权日:2018-09-24 标题 :Methods for preparation of substituted pyridines and related novel compounds 发明人:WATKINS EDMOND BLAKE; UREDI DILIPKUMAR; MOTATI DAMODER REDDY 权利人:WATKINS EDMOND BLAKE; UREDI DILIPKUMAR; MOTATI DAMODER REDDY; UNION UNIV 摘要:The present invention relates to novel methods of preparation of substituted pyridines and the compounds produced therefrom. In particular, the present invention provides efficient methods for the construction of diversely substituted pyridines, with varying substitution patterns under simple and metal-free conditions with high atom- and pot-economy and excellent functional group tolerance, and which are useful for the synthesis of natural products.
专利号:WO-2022256660-A1 优先权日:2021-06-04 标 题:Process for the synthesis of substituted tetrahydrofuran modulators of sodium channels 发明人:HARRISON CRISTIAN 权利人:VERTEX PHARMA 摘要:Provided in this application is a process for making Compound I (I) and pharmaceutically acceptable salts thereof, useful as inhibitors of sodium channels. Processes for making various intermediate products, and suitable salts thereof, are also provided.
专利号:US-3746745-A 优先权日:1971-03-31 标 题 :Synthesis of hexamethyl mellitate 发明人:CRAWFORD R 权利人:PROCTER & GAMBLE 摘要:AN IMPROVED PROCESS FOR SYNTHESIZING THE HEXAMETHYL ESTER OF MELLITIC ACID BY THE TRIMERIZATION OF DIMETHYL ACETYLENEDICARBOZYLATE WHICH MAXIMIZES PRODUCT YIELD AND MINIMIZES COSTLY REACTION TIME AND NEED FOR EXPENSIVE EQUIPMENT.
专利号:WO-2024037615-A1 优先权日:2022-08-19 标 题:Ionic covalent organic framework material, solid-phase synthesis method thereof, and use thereof 发明人:ZHANG ZHENJIE; ZHANG PENGHUI; WANG ZHIFANG; ZHANG YUSHU; CHEN YAO 权利人:YOCOF MAT TIANJIN CO LTD 摘要:The present invention provides a series of ionic vinyl covalent organic framework materials constructed in two ways by means of designing a novel method. Such materials feature high crystallinity and specific surface area, cost-efficiency, simple synthesis, capability of self-forming and mass production, and the like. The synthesis process avoids the use of organic solvents and thus the risks of high pressure during the reaction process, and thereby possesses suitability for mass production and industrial potential. In addition, the ionic COF materials have the capability of efficiently isolating oxygen-containing anions from water, and have great industrial application prospects.