CAS: 20579-43-5; 3,4,5-Trimethylpyridine

该化合物是含有分子式C8H11N的七环有机化合物,在3,4和5个位置上,以三甲基组替代三环环,该化合物因其在有机合成,特别是在生产药品,农用化学品和特殊化学品方面作为多用途中间体的作用而备受珍视,其稳定的芳香结构和富电子性质使其适合催化和协调化学应用.三甲基替代可增强消毒和电子特性,便于选择性反应.它通常以高纯度液体或固体形式供应,在研究和工业过程中具有持续质量,可产生可复制的结果.

结构式图片

相似化合物

30413-60-6 7584-05-6 74663-96-0

欧盟法规

ECHA物质ECHA物质C&L通报REACH预注册

合成工艺路线路线简述

  • 合成目标产物 3,4,5-Trimethylpyridine 主要起始原料 Trans-2-Methyl-2-Butenal And Propargylamine
  • (文献来源)合成步骤主要原料 Trans-2-Methyl-2-Butenal 和 Propargylamine
📜1-苄基-3,5-二甲基哌啶-4-酮置于platinum On Activated Charcoal,乙醚体系中,化学反应生成3,4,5-三甲基吡啶
参考文献:Vaculik; Kuthan,Collection Of Czechoslovak Chemical Communications,1959,Vol. 24,P. 174,176
标题:Vaculik; Kuthan,Collection Of Czechoslovak Chemical Communications,1959,Vol. 24,P. 174,176

海关参考信息

专利信息


专利号:US-5623068-A
优先权日:1994-03-07
标 题:Synthesis of DNA using substituted phenylacetyl-protected nucleotides
发明人:REDDY M PARAMESWARA; FAROOQUI FIRDOUS; HANNA NAEEM B
权利人:BECKMAN INSTRUMENTS INC
摘要:Deoxyribonucleotide and ribonucleotide derivatives of the general formula I I wherein R1 represents -CR'R''-Ar, in which Ar is substituted aryl (as hereinafter defined) and R' and R'' are independently selected from the group consisting of hydrogen and lower alkyl; one of -R2 and R3 is a hydroxyl-protecting group and the other is a group suitable for synthesis of polynucleotides or for attachment of the nucleotide to a solid support; R4 is selected from the group consisting of hydrogen, -OH and protected hydroxyl; and B represents a divalent radical corresponding to a purine or pyrimidine base. When synthesis is carried out using these derivatives, the deprotection procedure is reduced to an essentially instantaneous process. The derivatives have acceptable shelf life and are very stable to conventional DNA synthesis conditions. Particularly preferred are those compounds wherein Ar is mono- and dihalo-substituted phenyl.

专利号:US-6121454-A
优先权日:1997-05-06
标题 :Synthesis of pharmaceutically useful pyridine derivatives
发明人:ZOGHBI MICHEL; CHEN LIQUIN
权利人:PDI RESEARCH LAB INC
摘要:A process is provided for the preparation of compounds of formula I, useful in the preparation of compounds such as Omeprazole, Lansoprazole and Pantoprazole, wherein R1=H or CH3, R2=H or CH3, R3=Alkoxy (1-4C), OCH2CF3, Cyano, Hydrogen, Halogen, Acetoxy or Aryloxy, any electron withdrawing group or salts (organic or inorganic) of electron donating groups, R=Alkoxy, Hydroxy, Halogen, Activated ester, Tosylate, Mesylate, Thiol or Xanthyl, wherein the process for the preparation of compound of formula I employs a free radical reaction to functionalize the 2-position.

专利号:US-11117893-B2
优先权日:2018-09-24
标题 :Methods for preparation of substituted pyridines and related novel compounds
发明人:WATKINS EDMOND BLAKE; UREDI DILIPKUMAR; MOTATI DAMODER REDDY
权利人:WATKINS EDMOND BLAKE; UREDI DILIPKUMAR; MOTATI DAMODER REDDY; UNION UNIV
摘要:The present invention relates to novel methods of preparation of substituted pyridines and the compounds produced therefrom. In particular, the present invention provides efficient methods for the construction of diversely substituted pyridines, with varying substitution patterns under simple and metal-free conditions with high atom- and pot-economy and excellent functional group tolerance, and which are useful for the synthesis of natural products.

专利号:WO-2022256660-A1
优先权日:2021-06-04
标 题:Process for the synthesis of substituted tetrahydrofuran modulators of sodium channels
发明人:HARRISON CRISTIAN
权利人:VERTEX PHARMA
摘要:Provided in this application is a process for making Compound I (I) and pharmaceutically acceptable salts thereof, useful as inhibitors of sodium channels. Processes for making various intermediate products, and suitable salts thereof, are also provided.

专利号:US-3746745-A
优先权日:1971-03-31
标 题 :Synthesis of hexamethyl mellitate
发明人:CRAWFORD R
权利人:PROCTER & GAMBLE
摘要:AN IMPROVED PROCESS FOR SYNTHESIZING THE HEXAMETHYL ESTER OF MELLITIC ACID BY THE TRIMERIZATION OF DIMETHYL ACETYLENEDICARBOZYLATE WHICH MAXIMIZES PRODUCT YIELD AND MINIMIZES COSTLY REACTION TIME AND NEED FOR EXPENSIVE EQUIPMENT.

专利号:WO-2024037615-A1
优先权日:2022-08-19
标 题:Ionic covalent organic framework material, solid-phase synthesis method thereof, and use thereof
发明人:ZHANG ZHENJIE; ZHANG PENGHUI; WANG ZHIFANG; ZHANG YUSHU; CHEN YAO
权利人:YOCOF MAT TIANJIN CO LTD
摘要:The present invention provides a series of ionic vinyl covalent organic framework materials constructed in two ways by means of designing a novel method. Such materials feature high crystallinity and specific surface area, cost-efficiency, simple synthesis, capability of self-forming and mass production, and the like. The synthesis process avoids the use of organic solvents and thus the risks of high pressure during the reaction process, and thereby possesses suitability for mass production and industrial potential. In addition, the ionic COF materials have the capability of efficiently isolating oxygen-containing anions from water, and have great industrial application prospects.

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📌 第三方产品分析报告

✅ COA系统入驻 | 共享模式

合成参考文献


参考文献:10.1007/bf02675640
摘要:Gribov LA, Sidelov DI. Trends in the spectral distribution of the absorption coefficient of complex organic molecules. Journal of Applied Spectroscopy. 1998 Jul;65(4):508–13. doi: 10.1007/bf02675640.
参考文献:10.1007/bfb0051718
摘要:Lang KF, Eigen I. Im Steinkohlenteer nachgewiesene organische Verbindungen. 1967. In: Organische Chemie. : Springer-Verlag; 1967.
参考文献:10.1007/bf00505745
摘要:Sadimenko AP, Garnovskii AD, Sheinker VN, Osipov OA. σ,π Complexing capacities of heteroaromatic compounds (review). Chemistry of Heterocyclic Compounds. 1983 Oct;19(10):1031–41. doi: 10.1007/bf00505745.
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