CAS: 20099-89-2; 4-(2-Bromoacetyl)Benzonitrile

上下游产品

4-cyanophenyl methyl ketone methanol 4-ethylbenzonitrile 4-(2-bromoethynyl)-benzonitrile 4-[(pyridine-3-sulfonyl)-acetyl]-benzonitrile 4-(2-[1,2,4]triazol-1-ylacetyl)benzonitrile ω-ethythio-p-cyanoacetophenone 4-[2-(4-Butyl-phenyl)-imidazo[2,1-b][1,3,4]thiadiazol-6-yl]-benzonitrile

4-氰基苯乙烯置于1,3-二溴-5,5-二甲基海因,水体系中,化学反应 3.0H,反应生成2-溴-4'-氰基苯乙酮
参考文献:1,3-二溴-5,5-二甲基乙内酰脲介导的末端烯烃在水中的氧化酰胺化
标题:1,3-二溴-5,5-二甲基乙内酰脲介导的末端烯烃在水中的氧化酰胺化
摘要:通过用1,3-二溴-5,5-二甲基乙内酰脲处理,然后与分子碘和hcl水溶液反应,将多种末端烯烃在水中以25-86%的收率转化为相应的酰胺.一锅中加入nh 3(或胺).这种无金属和有机溶剂的方案不仅适用于苯乙烯衍生物,而且首次在末端脂族烯烃上效果很好.
Doi:10.1039/c7Ob02329D

专利信息

专利号:WO-2021038581-A1
优先权日:2019-08-30
标题 :A one step synthesis of 2-substituted benzo[b]thiophenes
发明人：SEKAR GOVINDASAMY; POONGUZHALI ELAMVAZHUTHI
权利人:INDIAN INST TECH MADRAS
摘要:The invention pertains to a one step synthesis of 2-substituted benzo[ b ]thiophene of general formula wherein the synthesis of 2-substituted benzo[ b ]thiophenes is by reacting the starting materials substituted or unsubstituted 2-halogenobenzaldehyde and substituted or unsubstituted acetyl/phenacyl bromide with a catalyst, a sulphur source and phase transfer catalyst in an aqueous medium with atmospheric air and at temperature in the range of 25°C-30°C.

专利号:US-8906915-B2
优先权日:2009-12-17
标 题:Compounds, compositions, and methods for controlling biofilms
发明人：DE KEERSMAECKER SIGRID; DE VOS DIRK; ERMOLATEV DENIS; STEENACKERS HANS; VAN DER EYCKEN ERIK; VANDERLEYDEN JOZEF; SAVALIYA BHARAT S
权利人:DE KEERSMAECKER SIGRID; DE VOS DIRK; ERMOLATEV DENIS; STEENACKERS HANS; VAN DER EYCKEN ERIK; VANDERLEYDEN JOZEF; SAVALIYA BHARAT S; UNIV LEUVEN KATH
摘要:The invention relates to substituted 2-aminoimidazoles and their imidazo[1,2-a]pyrimidinium salts precursors being active against biofilm formation. The invention also relates to imidazo[1,2-a]pyrimidinium salts bearing an azidoalkyl substituent, and to substituted 2-aminoimidazoles wherein the amino group bears a terminal heterocyclic group such as a triazolyl group which are formed through azide-alkyne Huisgen cycloaddition starting from said imidazo[1,2-a]pyrimidinium salts bearing an azidoalkyl substituent. The invention also relates to a class of N-(azidoalkyl)pyrimidin-2-amines useful as starting materials for the synthesis of said imidazo[1,2-a]pyrimidinium salts bearing an azidoalkyl substituent. The invention also relates to antimicrobial compositions that include a microbial biofilm formation inhibiting amount of such substituted 2-aminoimidazoles or imidazo[1,2-a]pyrimidinium salts in combination with excipients. Methods for inhibiting or controlling microbial biofilm formation in a plant, a body part of a human or an animal, or a surface with which a human or an animal may come into contact are also disclosed.

专利号:WO-2023237534-A1
优先权日:2022-06-07
标 题:A process for preparing isavuconazonium sulfate
发明人：HALUSZCZUK ADAM ANDRZEJ; KOSIK KAMIL; GRAUZENIS MACIEJ; BRODA EWA
权利人:ZAKL FARMACEUTYCZNE POLPHARMA S A
摘要:The present invention relates to a process for preparing isavuconazonium sulfate and a process for isolation and/or purification of isavuconazonium sulfate. Further, the invention relates to new isavuconazonium salts useful in the preparation and/or purification of isavuconazonium sulfate and a process for their preparation. Additionally, the invention provides a new intermediate useful in the synthesis of isavuconazonium.

专利号:US-9700543-B2
优先权日:2011-05-31
标题 :GLP-1 receptor stabilizers and modulators
发明人：BOEHM MARCUS F; MARTINBOROUGH ESTHER; MOORJANI MANISHA; TAMIYA JUNKO; HUANG LIMING; FOWLER THOMAS; NOVAK ANDREW; MEGHANI PREMJI; BRAHMACHARY ENUGURTHI; YEAGER ADAM RICHARD
权利人:CELGENE INT II SÀRL
摘要:Compounds that bind the glucagon-like peptide 1 (GLP-1) receptor, methods of their synthesis, methods of their therapeutic and/or prophylactic use, and methods of their use in stabilizing GLP-1 receptor in vitro for crystallization of the GLP-1 receptor are provided. Certain compounds may have activity as modulators or potentiators with respect to glucagon receptor, GIP receptor, GLP-1 and GLP-2 receptors, and PTH receptor on their own or in the presence of receptor ligands such as GIP(1-42), PTH(1-34), Glucagon(1-29), GLP-2(1-33), GLP-1(7-36), GLP-1(9-36), oxyntomodulin and exendin variants.

专利号:CN-101735800-B
优先权日:2007-10-17
标 题 :A class of organic electron transport and/or hole blocking material and its synthesis method and application

专利号:CN-116102524-A
优先权日:2023-02-28
标 题:A kind of asymmetric synthesis method of β-amino alcohol compound