CAS: 19676-64-3; 2,3,4-Trimethoxyphenol

该化合物是一种有机化合物,其特征是附于一个苯球环的三种甲氧(-OCH3)组,该化合物一般是白色至非白色固体的,可溶于有机溶剂,由于甲基氧替代成分而具有疏水性;酚结构中存在氢氧基(-OH)组,具有某种程度的极性,允许与极地溶剂发生可能的相互作用. 2,3,4-三甲基苯酚因其抗氧化特性而闻名,并可能展示生物活动,使其在各个领域,包括制药和天然产品化学领域都具有兴趣,其化学结构允许在合成更复杂的有机分子方面的潜在应用.此外,该化合物的稳定性和再活性可能受到甲基氧组的定位的影响,这可能影响其电子特性和化学反应的再活性.在处理和使用时,应参考安全数据,如任何化学物质一样.

结构式图片

欧盟法规

C&L通报

上下游产品

CAS号2103-57-3 2,3,4-三甲氧基苯甲醛 | CAS号634-36-6 1,2,3-三甲氧基苯 | CAS号41038-42-0 1-(2,3,4-Trimet... | CAS号13909-73-4 2',3',4'-三甲氧基苯乙酮 | CAS号39068-84-3 2-hydroxy-3,4,5... | CAS号67-66-3 氯仿 | CAS号10028-15-6 臭氧 | CAS号39068-88-7 2,3,4-三甲氧基-6-甲基苯酚 | CAS号605-94-7 2,3-二甲氧基-5-甲基-1,4-苯醌 | CAS号35896-58-3 2,3,4,5-四甲氧基甲苯 | CAS号478-01-3 川陈皮素; 蜜橘黄素; 川皮亭 | CAS号30225-99-1 2,3,4,5-tetrame... | CAS号30225-96-8 1-(2-hydroxy-3,... | CAS号3117-02-0 2,3-二甲氧基-1,4-苯醌 | CAS号73875-27-1 2-甲基-3, 4, 5, 6... | CAS号3117-05-3 2,3,5-trimethox... | CAS号127581-57-1 5-hydroxy-2,3,4...

合成工艺路线路线简述

    1,2,3-三甲氧基苯置于selenium(Iv) Oxide,双氧水,四氯化钛,三乙胺体系中,用 甲醇,二氯甲烷,叔丁醇 用作溶剂,化学反应 1.5H,反应生成2,3,4-三甲氧基苯酚
    参考文献:Pet Imaging Of Nobiletin Based On A Practical Total Synthesis
    标题:Pet Imaging Of Nobiletin Based On A Practical Total Synthesis
    摘要:一种实用的合成方法成功合成了多甲氧基化的柑橘黄酮-诺比利丁,采用了我们新开发的黄酮合成法.合成的诺比利丁通过选择性去甲基化和快速引入11C原子进行了标记.正电子发射断层扫描图像成功地可视化了其在大脑中的分布,这可能为阿尔茨海默病的治疗提供治疗性益处.
    Doi:10.1039/c0Cc04936K

    海关参考信息

    专利信息


    专利号:CN-102477452-A
    优先权日:2010-11-22
    标题:Enzymatic Synthesis of a Surfactant

    专利号:WO-0149681-A1
    优先权日:1999-12-30
    标题 :A method for the preparation of substituted benzene derivatives
    发明人:RUHLAND THOMAS; ROTTLAENDER MARIO; ANDERSEN KIM
    权利人:LUNDBECK & CO AS H; RUHLAND THOMAS; ROTTLAENDER MARIO; ANDERSEN KIM
    摘要:A method for the preparation of selectively substituted benzene derivatives by application of solid phase synthesis is disclosed. In particular, the invention provides a novel method for the preparation of substituted benzene derivatives containing two or three groups bound to the benzene ring via nitrogen-, oxygen-, sulphur-, selenium- or carbon-carbon bonds, by application of solid phase chemistry alone or in combination with post cleavage solution phase derivatisation.

    专利号:GB-1566874-A
    优先权日:1975-09-29
    标题:Process for synthesis of coenzyme

    专利号:GB-1566875-A
    优先权日:1975-09-29
    标题:Process for synthesis of coenzyme q compounds

    专利号:US-5734067-A
    优先权日:1994-09-28
    标题 :Anti-oxidative tricyclic, condensed heterocyclic compound
    发明人:JINNO SHUJI; KOGURE YASUYO; ONUKI HIROYUKI; OKITA TAKAAKI
    权利人:NIPPON SUISAN KAISHA LTD
    摘要:Providing a novel tricyclic, condensed heterocyclic compound having an anti-oxidative action and being promising for use in pharmaceutical agents, cosmetics, chemical products and the like. By chemical synthesis, a novel anti-oxidative, tricyclic, condensed heterocyclic compound represented by the following formula: ##STR1## (wherein X--Y represents CH 2 --Câ• O, CH 2 --CH 2 or CHâ• CH; Z represents O, S, or Sâ• O; R 1 to R 8 represent independently those selected from the group consisting of hydrogen atom, a hydroxyl group, a halogen group, a lower alkyl group, a lower alkoxyl group, a lower alkyl ketone group and CF 3 ; and at least two of R 1 to R 4 are hydroxyl groups); and the salts thereof are provided. The compound has an anti-oxidative activity at the same degree as or higher than the activity of α-tocopherol, so the compound is promising as a therapeutic drug for a variety of diseases, such as cancer, arteriosclerosis, or liver diseases, in which it is believed that biological lipid peroxides may b involved.

    专利号:CN-110498739-A
    优先权日:2019-09-12
    标题:A method of synthesis 6- hydroxyl -2,3,4- trimethoxy-alpha-chloro acetophenone
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    合成参考文献


    参考文献:10.1007/s11095-005-8813-4
    摘要:Fedorov SN, Radchenko OS, Shubina LK, Balaneva NN, Bode AM, Stonik VA, Dong Z. Evaluation of Cancer-Preventive Activity and Structure–Activity Relationships of 3-Demethylubiquinone Q2, Isolated from the Ascidian Aplidium glabrum, and its Synthetic Analogs. Pharmaceutical Research. 2006 Jan;23(1):70–81. doi: 10.1007/s11095-005-8813-4.
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