CAS: 143-50-0; Chlordecone

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hexachlor°Cyclopentadiene2,5.03,8.04,7>nonan-4-carbonsaeureNonachloropentacyclo4.3.0.02,5.03,8.04,7nonan-4-carbonsaeure 17H8Cl10O2C17H8Cl10O2 18H10Cl10O2C18H10Cl10O2

📜十氯酮-醇,Nadp+ 反应生成开蓬,氢(+1)阳离子,Nadph(4-)
参考文献:Characterization Of A Unique Aldo‐keto Reductase Responsible For The Reduction Of Chlordecone In The Liver Of The Gerbil And Man
标题:Characterization Of A Unique Aldo‐keto Reductase Responsible For The Reduction Of Chlordecone In The Liver Of The Gerbil And Man
摘要:It Has Been Established That The Major Metabolic Pathway For Chlordecone (Cd) (Kepone) Both In Humans And In The Mongolian Gerbil Is Bioreduction Of This Organochlorine Pesticide To Chlordecone Alcohol (Cdoh) In The Liver. In The Present Study We Developed A Gas-Liquid Chromatography Assay To Measure The Enzymatic Reduction Of Cd To Cdoh In Vitro And Characterized "Cd Reductase" Activity In Gerbil Liver Cytosol. Cd Reductase Is A Cytosolic Enzyme Readily Detectable In Liver Samples Prepared From Humans,Rabbits,And Gerbils,The Only Species Of Many Tested That Convert Cd To Cdoh In Vivo. Gerbil Cd Reductase Exhibited A Km Of 2.6 Microm,A Vmax Of 0.14 Nmol/min,And A Ph Optimum Of 6.5. The Enzyme Activity Required Nadph,Was Sensitive To Thiol Reagents,And Was Distributed In All Tissues With The Highest Activities Found In The Liver,Intestine,And Kidneys. These Results Are Consistent With Cd Reductase Belonging To The Family Of Enzymes Referred To As The "Aldo-Keto Reductases." However,Unlike Previously Described Reductases,Cd Reductase Was Undetectable In Rats,Mice,Hamsters,Or Guinea Pigs And Was Insensitive To The Model Aldehyde And Ketone Reductase Inhibitors,Phenobarbital And Quercetin,Respectively. In Addition,Cd Reductase Activity In Liver Was Increased By 38% (P Less Than 0.01) Following Treatment Of Gerbils With Cd. We Conclude That Cd Reductase Is A Novel Aldo-Keto Reductase That Is Uniquely Inducible By Its Substrate.
Doi:10.1080/15287398609530832

专利信息

专利号:EP-1789107-B1
优先权日:2004-08-30
标题 :Medical stent provided with inhibitors of atp synthesis
发明人：POPOWSKI YOURI
权利人:INTERSTITIAL THERAPEUTICS
摘要:The present invention relates to a stent provided with a composition comprising at least one type of inhibitor of ATP synthesis optionally together with at least one inhibitor of the pentose phosphate pathway (PPP) for use in treating stenosis and preventing restenosis in vascular ducts, and for use in treating cancerous tumours present in ducts, resectioned cavities and scars, and for use in treating any disorder arising from the proliferation of cells in ducts or cavities.

专利号:US-5900227-A
优先权日:1996-06-17
标题 :Multicyclic nitrone spin trapping compositions
发明人：JANZEN EDWARD G; SANKURATRI NAGARAJU
权利人:OKLAHOMA MED RES FOUND
摘要:Multicyclic nitrone spin trapping compounds capable of forming stable free radical spin adducts are provided as well as methods for their synthesis. The multicyclic nitrone spin trapping compounds can be reacted with a free radical, such as a hydroxy or hydroperoxy radical, in solution to form a spin adduct which is stable and readily detectable by electron paramagnetic resonance (EPR) spectroscopy. The multicyclic nitrone spin traps can be used to detect free radicals in a sample such as a biological system. In one embodiment, the spin trapping compound, 1,3,3-trimethyl-6-azabicyclo-[3.2.1]oct-6-ene-N-oxide ('TRAZON') is provided, as well as methods for the synthesis of TRAZON and of modified forms of TRAZON. TRAZON can react with a wide range of different free radicals in solution to form free radical spin adducts which are readily detectable by EPR.

专利号:US-7365178-B2
优先权日:2003-04-01
标 题:Acyl-nucleotide probes and methods of their synthesis and use in proteomic analysis
发明人：CAMPBELL DAVID ALAN; LIYANAGE MAREK; SZARDENINGS ANNA KATRIN; WU MIN
权利人:ACTIVX BIOSCIENCES INC
摘要:The present invention provides tagged acyl phosphate probes (“TAPPsâ€?), and methods of their preparation and use. The subject methods and compositions can provide enhanced simplicity and accuracy in identifying changes in the presence, amount, or activity of target proteins in a complex protein mixture, preferably nucleotide binding proteins using nucleotide binding protein-directed TAPPs. The profiling methods described herein can have a number of steps leading to the identification of target nucleotide binding protein(s) in a complex protein mixture.

专利号:WO-2021074309-A1
优先权日:2019-10-16
标 题:1-(3-quinolyl)-3,4-dihydroisoquinoline derivatives as fungicides for combating specific phytopathogens
发明人：WEISS MATTHIAS; QUARANTA LAURA; BOU HAMDAN FARHAN; MAHAJAN ATUL; WILLIAMS SIMON; KILARU JAGADEESH; SEN INDIRA; BIERI STEPHANE; DIGGELMANN MARTIN
权利人:SYNGENTA CROP PROTECTION AG
摘要:1-(3-quinolyl)-3,4-dihydroisoquinoline derivatives of formula (I) as well as a method of combating, preventing or controlling the phytopathogens Mycosphaerella graminicola (Septoria tritici), Fusarium culmorum, Gibberella zeae (Fusarium graminearum) and Monographella nivalis (Microdochium nivale), which comprises applying to the phytopathogen, to the locus of the phytopathogen, or to a plant susceptible to attack by the phytopathogen, or to propagation material thereof, a fungicidally effective amount of a 1-(3-quinolyl)-3,4-dihydroisoquinoline derivative of formula (I). The present description discloses the synthesis of exemplary compounds, formulation examples, relevant biological data (antifungal activity against Mycosphaerella graminicola (Septoria tritici), Fusarium culmorum, Gibberella zeae (Fusarium graminearum) and Monographella nivalis (Microdochium nivale) when spayed on plants), as well as comparative data against three prior art compounds (e.g. pages 52 to 85; formulation examples; examples A1 to A3; table E; compounds E.01 to E.187; biological examples). Exemplary compounds are e.g.: 5-bromo-1-(8-fluoro-3-quinolyl)spiro[4H-isoquinoline-3,1'- cyclopropane] (example A1) 5-bromo-1-(8-fluoro-3-quinolyl)-3,3-dimethyl-4H-isoquinoline (example A2) 1-(8-fluoro-3-quinolyl)-3,3-dimethyl-4H-isoquinoline-5-carbonitrile (example A3)

专利号:WO-2021074311-A1
优先权日:2019-10-16
标题:1-(3-quinolyl)-1,2,3,4-tetrahydroisoquinoline derivatives as fungicides for combating specific phytopathogens
发明人：WEISS MATTHIAS; QUARANTA LAURA; BOU HAMDAN FARHAN; MAHAJAN ATUL; WILLIAMS SIMON; KILARU JAGADEESH; BIERI STEPHANE; DIGGELMANN MARTIN
权利人:SYNGENTA CROP PROTECTION AG
摘要:1-(3-quinolyl)-1,2,3,4-tetrahydroisoquinoline derivatives of formula (I) as well as a method of combating, preventing or controlling the phytopathogens Mycosphaerella graminicola (Septoria tritici), Fusarium culmorum, Gibberella zeae (Fusarium graminearum) and Monographella nivalis (Microdochium nivale), which comprises applying to the phytopathogen, to the locus of the phytopathogen, or to a plant susceptible to attack by the phytopathogen, or to propagation material thereof, a fungicidally effective amount of a 1-(3-quinolyl)-1,2,3,4-tetrahydroisoquinoline derivatives of formula (I). The present description discloses the synthesis of exemplary compounds, formulation examples, relevant biological data (antifungal activity against Mycosphaerella graminicola, Monographella nivalis, Fusarium culmorum and/or Gibberella zeae when spayed on plants) (e.g. pages 47 to 55; examples A1 and A2; compounds E.01 to E.17; table E). An exemplary compounds is e.g.: 3-(5-bromo-3,3-dimethyl-2,4-dihydro-1 H-isoquinolin-1-yl)-8-fluoro- quinoline (example A1)

专利号:US-11702652-B2
优先权日:2005-12-01
标题:Enzymatic encoding methods for efficient synthesis of large libraries