CAS: 13074-31-2; 1-(3,4-Dimethoxybenzyl)-6,7-Dimethoxy-1,2,3,4-Tetrahydroisoquinoline

该化合物是一种合成四氢索基尼衍生物,其特征是其角氧替代芳香环.该化合物在结构上与生物活性藻类相似,可能具有潜在的药理特性,因此对医药化学具有兴趣.多种甲基氧基组的存在增强了其亲脂性,有可能改善膜渗透性.其定义明确的分子结构允许精确的修改,使其成为有机合成和药物开发的宝贵中间体.该化合物在标准条件下的稳定确保了可靠的处理和储存.鉴于其与已知的生物活性肉类具有结构相似性,进一步的研究可能会探索其针对...

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54417-53-7 6429-04-5 6429-04-5

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CAS号58-74-2 罂粟碱 | CAS号6957-27-3 3,4-二氢罂粟碱 | CAS号6429-04-5 四氢罂粟碱盐酸盐 | CAS号139-76-4 N-(3,4-二甲氧基苯乙基)... | CAS号93-40-3 3,4-二甲氧基苯乙酸 | CAS号119952-74-8 3,4-dihydropapa... | CAS号120-20-7 3,4-二甲氧基苯乙胺 | CAS号50896-90-7 R-四氢罂粟碱 | CAS号4747-98-2 S-四氢罂粟碱 | CAS号5574-24-3 氧代海罂粟碱 | CAS号3382-18-1 6,7-二甲氧基-3,4-二氢异喹啉 | CAS号6957-27-3 3,4-二氢罂粟碱 | CAS号58-74-2 罂粟碱 | CAS号6429-04-5 四氢罂粟碱盐酸盐 | CAS号31537-71-0 rac N-乙酰去甲罗丹丹素 | CAS号522-57-6 罌粟啶

合成工艺路线路线简述

    📜罂粟碱置于乙醇,镍体系中,150.0 °C,14.71 Mpa 条件下,反应生成1,2,3,4-四氢罂粟碱
    参考文献:Curariform Activity And Chemical Structure. Ii. Synthesis In The Benzyltetrahydroisoquinoline Series1
    标题:Curariform Activity And Chemical Structure. Ii. Synthesis In The Benzyltetrahydroisoquinoline Series1
    摘要:
    Doi:10.1021/ja01188A044

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    专利信息


    专利号:US-12098126-B2
    优先权日:2021-08-23
    标题:Methods of iron catalyzed C-H bond amination
    发明人：CHE CHI-MING; YOU TINGJIE
    权利人:VERSITECH LTD; LABORATORY FOR SYNTHETIC CHEMISTRY AND CHEMICAL BIOLOGY LTD
    摘要:Described herein is an iron(II)-phthalocyanine catalyzed C—H bond amination of alkyl azides. The catalyst is effective to produce intramolecular amination of saturated C—H bonds in moderate to excellent yields and the methods are tolerant of a wide scope of substrates. The methods described are useful for the synthesis of natural products derivatives and for the late-stage functionalization of pharmaceuticals.

    专利号:US-8148527-B1
    优先权日:2011-01-18
    标 题:Resolution of 1-(4-methoxybenzyl)-octahydro-isoquinoline
    发明人：DIVI MURALI KRISHNA PRASAD; PENDYALA SRINIVAS RAO; RAMANA LAVU VENKATA
    权利人:DIVI MURALI KRISHNA PRASAD; PENDYALA SRINIVAS RAO; RAMANA LAVU VENKATA; DIVIS LAB LTD
    摘要:The resolution of racemic 1-(4-methoxybenzyl)-octahydro-isoquinoline, a key intermediate in the synthesis of the antitussive agent dextromethorphan, is reported using (R)-2-(6-methoxy-2-naphthyl) propionic acid in good yields. The resolving agent and the undesired isomer of the octahydro-isoquinoline have been recovered in good yield.

    专利号:CN-101402602-A
    优先权日:2008-11-21
    标题 :Degradation recycling method for by-product in synthesis of tetrahydrochysene isoquinoline derivative

    专利号:CN-115124466-B
    优先权日:2022-07-19
    标题 :A kind of synthesis method of tetrahydropapaverine hydrochloride

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    合成参考文献


    参考文献:10.1007/bf03190571
    摘要:Aneja R, Katyal A, Chandra R. Stimulation of lipid peroxidation and impairment of glutathione-dependent defense system in wistar rats treated with cryptopine, a rare non-narcotic opium alkaloid. European Journal of Drug Metabolism and Pharmacokinetics. 2004 Mar;29(1):31–6. doi: 10.1007/bf03190571.
    参考文献:10.1016/j.lfs.2004.04.017
    摘要:Kim EI, Kang MH, Lee MK. Inhibitory effects of tetrahydropapaverine on serotonin biosynthesis in murine mastocytoma P815 cells. Life Sci. 2004 Sep 03;75(16):1949–57. doi: 10.1016/j.lfs.2004.04.017.
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