CAS: 1116-22-9; L-γ-Glutamyl-L-Glutamic Acid

相似化合物

145817-20-5 10148-81-9 2490-97-3

上下游产品

CAS号7365-90-4 benzyloxycarbon... | CAS号3705-42-8 Cbz-L-谷氨酸 1-苄酯 | CAS号13030-09-6 L-谷氨酸-α-苄酯 | CAS号7365-91-5 benzyloxycarbon... | CAS号56-86-0 L-谷氨酸 | CAS号2768-50-5 H-Glu(OBzl)-OBzl | CAS号16450-41-2 谷氨酸二乙酯 | CAS号56-85-9 L-谷氨酰胺 | CAS号56-86-0 L-谷氨酸

📜N-Benzyloxycarbonyl-L-Glutamic Acid-5-Hydrazide置于sodium Hydroxide,氯仿体系中,化学反应生成α-L-谷氨酰-L-谷氨酸
参考文献:399.氨基酸和肽.第一部分.在羧甲基肽合成中使用羧苄氧基-L-谷氨酸酐的研究
标题:399.氨基酸和肽.第一部分.在羧甲基肽合成中使用羧苄氧基-L-谷氨酸酐的研究
摘要:
Doi:10.1039/jr9500001954

专利信息

专利号:US-8552163-B2
优先权日:2009-09-25
标题 :Liver-targeting agents and their synthesis
发明人：LEE REIKO TAKASAKA; LEE YUAN-CHUAN; WANG MEI-HUI; LIN WUU-JYH
权利人:LEE REIKO TAKASAKA; LEE YUAN-CHUAN; WANG MEI-HUI; LIN WUU-JYH; UNIV JOHNS HOPKINS; INER AEC EXECUTIVE YUAN
摘要:This invention provides novel liver targeting agents and their synthetic methods. A liver targeting agent, with a lysine based nitrilotriacetic acid structure as backbone which acquires multivalency with saccharide groups, to bind with a galactosamine chain or lactose chain is disclosed. In particular, only one amino acid L-lysine is involved to provide trivalency. All carboxyl groups in N ε -benzyloxycarbonyl-N α -dicarboxymethyl-L-lysine can be conjugated with three glycosides of ahGalNAc or ahLac in one step. This invention also provides a hexa-lactoside. In particular, the TFA-AHA-Asp was used to conjugate 2 molecules of NTA(ahLac) 3 . This invention also provides a method for adding a spacer between NTA and DTPA. The extended hepatocyte-specific glyco-ligand has higher 111 In-radiolabelling yield than those non-extended.

专利号:US-6166003-A
优先权日:1999-02-17
标 题 :Heterocyclic compounds for cancer chemoprevention
发明人：LAM LUKE K T
权利人:LKT LAB INC
摘要:A compound comprising a heterocyclic moiety, such as a thiophene, covalently attached to an alkylene isothiocyanate moiety. The compound is effective to prevent the occurrence or progression of cancer or a precancerous condition, and can be used for therapeutic or prophylactic purposes. The compound can be provided and administered in the form of a pharmaceutical composition, a cosmetic, a food additive, supplement, or the like. Methods for synthesis and use of the chemopreventive compound of the invention are also provided.