CAS: 1115-22-6; N,N-Dimethyl-L-Aspartic Acid

相似化合物

6384-92-5 17833-53-3 7545-54-2

上下游产品

N-甲基-L-天冬氨酸 N-Methyl-L-Aspartic Acid 4226-18-0
L-天门冬氨酸 L-Aspartic Acid 56-84-8

📜N-甲基-L-天冬氨酸 反应生成二甲基天冬氨酸
参考文献:Kondo; Sezaki; Koike,Journal Of Antibiotics,1965,Vol. 18,# 4,P. 192-194
标题:Kondo; Sezaki; Koike,Journal Of Antibiotics,1965,Vol. 18,# 4,P. 192-194

专利信息

专利号:US-5144073-A
优先权日:1988-08-31
标 题 :Process for preparation of dipeptides
发明人：HUBBS JOHN C
权利人:HUBBS JOHN C
摘要:Disclosed is a process for synthesis of a dipeptide such as N-acetyl-L- alpha -aspartyl-L-phenylalanine methyl ester wherein one amino acid serves as a chiral template which allows for synthesis of a second amino acid residue to form said dipeptide. The process involves several novel steps such as a nucleophile addition step. In addition, several novel intermediates are described.

专利号:US-6077962-A
优先权日:1998-12-24
标题 :N-3, 3-dimethylbutyl-L-aspartic acid and esters thereof, the process of preparing the same, and the process for preparing N-(N-(3,3-dimethylbutyl) -α L-aspartyl)-L- phenylalanine 1-methyl ester therefrom
发明人：PRAKASH INDRA; CHAPEAU MARIE-CHRISTINE D
权利人:NUTRASWEET CO
摘要:This invention relates to the chemical synthesis of N-[N-(3,3-dimethylbutyl)-L-α-aspartyl]-L-phenylalanine 1-methyl ester using peptide coupling methods. The coupling reaction is conducted by condensation of an activated derivative of novel N-neohexyl-L-aspartic acid with L-phenylalanine or L-phenylalanine methyl ester or by enzymatic coupling of N-neohexyl-L-aspartic acid with L-phenylalanine or L-phenylalanine methyl ester. This invention also relates to novel N-(3,3-dimethylbutyl)-L-aspartic acid, derivatives thereof and the preparation thereof. The activated derivative of N-neohexyl-L-aspartic acid may be an anhydride, mixed anhydride, active ester or an intermediate activated derivative thereof.

专利号:US-7514573-B2
优先权日:2007-04-11
标题:Processes for the manufacture of chiral and racemic forms of 3-aminotetrahydrofurans, their salts and derivatives
发明人：MAJEED MUHAMMED; NAGABHUSHANAM KALYANAM; BALAKRISHNAN SIVAPRSKASH KURUMANGHAT; GANJIHAL SAVITA; RAMANUJAM RAJENDRAN; SOOD RATTAN; PRAKASH SUBBALAKSHMI
权利人:SAMI LABS LTD
摘要:A novel process for the synthesis of (S)-3-Amino-tetrahydrofuran and (R)-3-Amino-tetrahydrofuran is described. The process is applicable for substituted chiral-3-aminotetrahydrofuran derivatives.

专利号:US-2004053999-A1
优先权日:1997-09-17
标题 :Novel compounds and methods for synthesis and therapy
发明人：BISCHOFBERGER NORBERT W; DAHL TERRENCE C; HITCHCOCK MICHAEL J M; KIM CHOUNG U; LEW WILLARD; LIU HONGTAO; MILLS ROGER G; WILLIAMS MATTHEW A
摘要:Novel compounds are described. The compounds generally comprise an acidic group, a basic group, a substituted amino or N-acyl and a group having an optionally hydroxylated alkane moiety. Pharmaceutical compositions comprising the inhibitors of the invention are also described. Methods of inhibiting neuraminidase in samples suspected of containing neuraminidase are also described. Antigenic materials, polymers, antibodies, conjugates of the compounds of the invention with labels, and assay methods for detecting neuraminidase activity are also described.

专利号:EP-0643710-A1
优先权日:1991-06-03
标 题 :Synthesis of optically active lactones from l-aspartic acid and intermediates thereof

专利号:US-5322942-A
优先权日:1991-06-03
标题 :Synthesis of optically active lactones from L-aspartic acid and intermediates thereof
发明人：RAPOPORT HENRY; DENER JEFFREY M; ZHANG LIN-HAU
权利人:UNIV CALIFORNIA
摘要:Optically active lactones are described, such as an intermediate lactone having the formula ##STR1## where R and R 2 are each independently alkyl with 1 to 6 carbon atoms, cycloalkyl with 6 to 10 carbon atoms, aryl with 6 to 10 carbon atoms, or arylalkyl with 7 to 19 carbon atoms, R 4 is H or C 1-6 alkyl, and Ar is a homo- or heteroaromatic ring with 5 or 6 ring atoms being optionally substituted by C 1-6 alkyl or alkoxy groups, halogen atoms, cyano or nitro groups. Such optically active, intermediate lactones are prepared from L-aspartic acid, and can be readily converted to (+)-pilocarpine and its analogues by hydrolysis, reduction, and hydrogenation, such as to an optically active lactone having the formula ##STR2## which is (+)-pilocarpine when R is ethyl, R 4 is H, and Ar is 1-methylimidazol-5-yl.