CAS: 10281-55-7; 1,6-Octadiene, 3,7-Dimethyl-, (S)-

该化合物是手性有机化合物,具有双重联系和特定的立体化学特征,其直线碳链共8个碳原子,在第一和第二位置有2个双联,有助于将其划为死物,在第三和第四位置上存在甲基组,增加了其复杂性并影响其再活动性和物理特性.作为手性分子,它以两种对应形式存在,其中一种是(S)结构,可能对生物活动和相互作用产生影响.这种化合物一般没有色,可能具有许多碳氢化合物共同的特征,其应用范围从有机合成用途到特殊化学品生产中的潜在作用或各种化学过程中的中间作用,在处理和储存时,应参考安全数据,因为许多不饱和碳氢化合物可能构成易燃性风险.

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    专利信息


    专利号:US-6989450-B2
    优先权日:2000-10-13
    标 题:Synthesis of epothilones and related analogs
    发明人:AVERY MITCHELL A
    权利人:UNIV MISSISSIPPI
    摘要:The present invention relates to methods for use in producing epothilones and analogs and derivatives thereof. A general method according to the present invention broadly comprises performing an aldol condensation of a first compound with a second compound thereby to form a third compound selected from the formulas: n n nand stereoisomers thereof, and performing a macrolactonization of the third compound. The present invention also provides chemical compounds, and methods for producing such chemical compounds, that are useful in producing epothilones and analogs and derivatives thereof.

    专利号:US-2002091269-A1
    优先权日:2000-10-13
    标题 :Synthesis of epothilones and related analogs

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    合成参考文献


    摘要:de Meijere, A.; Kozhushkov, S. I., Science of Synthesis, (2009) 48, 567.
    摘要:Fleischer, I.; Mejía, E., Science of Synthesis: C-1 Building Blocks in Organic Synthesis, (2013) 1, 160.
    摘要:Baudrenghien, L.; Markó, I. E., Science of Synthesis: N-Heterocyclic Carbenes in Catalytic Organic Synthesis, (2016) 1, 311.
    摘要:Garve, L. K. B.; Werz, D. B., Science of Synthesis: Metal-Catalyzed Cyclization Reactions, (2016) 2, 85.
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