专利号:US-6989450-B2 优先权日:2000-10-13 标 题:Synthesis of epothilones and related analogs 发明人:AVERY MITCHELL A 权利人:UNIV MISSISSIPPI 摘要:The present invention relates to methods for use in producing epothilones and analogs and derivatives thereof. A general method according to the present invention broadly comprises performing an aldol condensation of a first compound with a second compound thereby to form a third compound selected from the formulas: n n nand stereoisomers thereof, and performing a macrolactonization of the third compound. The present invention also provides chemical compounds, and methods for producing such chemical compounds, that are useful in producing epothilones and analogs and derivatives thereof.
专利号:US-2002091269-A1 优先权日:2000-10-13 标题 :Synthesis of epothilones and related analogs
摘要:de Meijere, A.; Kozhushkov, S. I., Science of Synthesis, (2009) 48, 567. 摘要:Fleischer, I.; Mejía, E., Science of Synthesis: C-1 Building Blocks in Organic Synthesis, (2013) 1, 160. 摘要:Baudrenghien, L.; Markó, I. E., Science of Synthesis: N-Heterocyclic Carbenes in Catalytic Organic Synthesis, (2016) 1, 311. 摘要:Garve, L. K. B.; Werz, D. B., Science of Synthesis: Metal-Catalyzed Cyclization Reactions, (2016) 2, 85.