CAS: 93-67-4; 5-Chloro-2-Phenoxyaniline

• 英文名称5-Chloro-2-Phenoxyaniline
• 中文名称2-氨基-4-氯二苯基醚
• IUPAC名称5-chloro-2-phenoxyaniline
• 其它别名5-氯-2-苯氧基苯胺; 4-Chloro-2-Aminodiphenyl Ether
• CAS编号93-67-4
• MFCD编号:MFCD00025217
• EINECS号:202-266-5
• FDA UNII编号:66SM796MDB
• 分子式:C12H10ClNO
• 分子量:219.67
• 产品CID: 1976626
• 产品分类有机原料→分子砌块→芳环类化合物→苯类化合物

• 相似结构搜索
• 产品信息参考;;;
• InChIKey: SXEBHIMOUHBBOS-UHFFFAOYSA-N
• InChI=1S/C12H10ClNO/c13-9-6-7-12(11(14)8-9)15-10-4-2-1-3-5-10/h1-8H,14H2…
• 计算化学: 氢键受体数2.0氢键供体数1.0可旋转键数2.0

物理性质

• 熔点41-44°C
• 沸点192 °C at 12 mmHg
• 闪点150.3±23.7 °C
• 密度1.3±0.1 g/cm3
• pKa:3.08±0.10(预测)
• PSA:35.25
• LogP:3.7145
• 折射率1.628
• 蒸汽压0.0±0.7 mmHg at 25°C
• 外观形态白色至灰色至棕色粉末至晶体
• 储存条件请置于阴暗处, 惰性气氛中,室温
• 产品应用是合成酸性染料的重要中间体,主要用于生产C.I酸性红149和C.I酸性蓝128.
• 性质描述浅黄色到浅绿色晶体.熔点45°C.

MSDS等安全信息

• GHS象形图
• GHS符号GHS08 & GHS07;
  注释: Health hazard & Exclamation mark
• 危险类别致突变性 类别2
  急性毒性 类别4(经口)
  皮肤腐蚀/刺激 类别2
  严重眼刺激 类别2
  水生慢性毒性 类别4
  特定目标器官毒性 - 单次接触 类别3
• 警示词Warning(警告)
• 危险描述H341 |怀疑导致遗传缺陷.
  H302 |吞咽有害.
  H315 |造成皮肤刺激.
  H319 |造成严重眼刺激.
  H413 |可能对水生生物造成长期有害影响.
  H335 |可能引起呼吸道刺激.
• 防范说明P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
• 危险等级IRRITANT
• UN编号NONH for all modes of transport
• 危险品标志Xi
• 安全声明26-36
• 危险类别码36/37/38
• WGK Germany2

欧盟法规

上下游产品

合成工艺路线路线简述

• 89-61-2 = 93-67-4
  反应条件:1.1 Reagents: Diglyme,Polyethylene Glycol; 0.5 H,Rt -> 100 °C1.2 Reagents: Sodium Hydroxide; 100 °C -> 125 °C; 240 Min,125 °C; 125 °C -> 60 °C1.3 Catalysts: Carbon,Iron Chloride (Fecl3) Solvents: Ethanol,Water; 120 Min,Rt -> Reflux1.4 Reagents: Hydrazine Hydrate (1:1) Catalysts: Benzyltriethylammonium Chloride Solvents: Ethanol,Water; 220 Min,Reflux; Reflux -> 40 °C1.5 Reagents: Water; 40 °C -> 20 °C
  标题:A Process For Preparing Amino-Containing Aromatic Ethers
  参考文献:China]
  
  91-39-4 = 93-67-4
  反应条件:1.1 Reagents: Hydrogen Catalysts: Nickel Solvents: Methanol; 70 Psi,Rt
  标题:Synthesis And Evaluation Of Antipsychotic Activity Of 11-(4-Aryl-1-Piperazinyl)Dibenz[b,F][1,4]Oxazepines And Their 8-Chloro Analogues
  作者:Wagh,B. S.; Patil,B. P.; Jain,M. S.; Harak,S. S.; Wagh,S. B.
  参考文献:Heterocyclic Communications 日期:2007 卷标:13(2-3) 页码:165-172]
  
  91-39-4 = 93-67-4
  反应条件:1.1 Reagents: Hydrogen Catalysts: Nickel Solvents: Methanol; 3 H,70 Psi,Rt
  标题:Preparation Of 8-Chloro-11-(1-Piperazinyl)-Dibenz[b,F][1,4]Oxazepines As Antipsychotic Agents
  参考文献:India]
  
  91-39-4 = 93-67-4
  反应条件:1.1 Reagents: Acetic Acid,Magnesium Solvents: Water; Rt -> 100 °C; 0.5 H,95 - 100 °C; 100 °C -> 70 °C1.2 70 °C -> Reflux; 1 H,Reflux; Reflux -> 95 °C1.3 Reagents: Iron; 90 - 95 °C; 1 H,95 °C -> Reflux; Reflux -> 80 °C; 80 °C; 1 H,80 °C -> Reflux; 6 H,Reflux; Reflux -> 70 °C
  标题:Preparation Of Polar Brilliant Red B
  作者:Han,Xiaobin; Liu,Xidong
  参考文献:Pige Huagong 日期:2007 卷标:24(3) 页码:14-17]
  
  = 93-67-4 [标题:Reaction Conditions
  标题:Preparation Of 1,6- And 1,8-Naphthyridines As Antiviral Compounds For Treatment Of Hcv Infections
  参考文献:United States]
  
  = 93-67-4 [标题:Reaction Conditions
  标题:Preparation Of 2-,3-,5-,8-,10- And/or 11-Substituted Dibenzoxazepine Compounds,Pharmaceutical Compositions And Methods For Treating Pain
  参考文献:United States]
  
  = 93-67-4 [标题:Reaction Conditions
  标题:Substituted Dibenzoxazepines Or Dibenothiazepines And Their Use As Prostaglandin E2 Antagonists
  参考文献:World Intellectual Property Organization]
  
  = 93-67-4 [标题:Reaction Conditions
  标题:Urea Derivatives And Their Use
  参考文献:European Patent Organization]
  
  = 93-67-4 [标题:Reaction Conditions
  标题:Reduction Of Aromatic Nitro Compounds
  参考文献:Japan]
  
  91-39-4 = 93-67-4
  反应条件:1.1 Reagents: Iron,Hydrochloric Acid Solvents: Ethanol,Water; Rt; 5 H,90 °C1.2 Reagents: Sodium Hydroxide Solvents: Water; Basified
  标题:An Unexpected Synthesis Of Azepinone Derivatives Through A Metal-Free Photochemical Cascade Reaction
  作者:Song,Lina; Tian,Xianhai; Farshadfar,Kaveh; Shiri,Farshad; Rominger,Frank; Et Al
  参考文献:Nature Communications 日期:2023 卷标:14(1)]
  
  89-61-2 = 93-67-4
  反应条件:1.1 Reagents: Sodium Hydroxide Catalysts: D-Glucopyranose,Oligomeric,Decyl Octyl Glycosides; 100 °C -> 120 °C; 240 Min,120 °C; 120 °C -> 60 °C1.2 Reagents: Hydrazine Hydrate (1:1) Catalysts: Tetraethylammonium Hydroxide,Sodium Aluminate Solvents: Ethanol,Water; 60 °C -> Reflux; 220 Min,Reflux
  标题:Synthesis Of 5-Chloro-2-Phenoxy Aniline And Beta Molecular Sieve Used For The Same
  参考文献:China]
  
  91-39-4 = 93-67-4
  反应条件:1.1 Reagents: Sodium Hydroxide,Hydrazine Hydrate (1:1),Ferric Chloride Hexahydrate Solvents: Ethanol,Water; 2 H,Ph 7.3,80 - 90 °C; 3 H,80 - 90 °C
  标题:Process For Preparation Of 2-Amino-4-Chlorodiphenyl Ether
  参考文献:China]
  
  91-39-4 = 93-67-4
  反应条件:1.1 Reagents: Stannous Chloride Solvents: Ethanol; 16 H,Rt1.2 Reagents: Sodium Hydroxide Solvents: Water; Ph 12
  标题:Antiviral Compounds,Their Preparation,Pharmaceutical Compositions,And Use In Therapy
  参考文献:World Intellectual Property Organization]
  
  91-39-4 = 93-67-4
  反应条件:1.1 Reagents: Stannous Chloride Solvents: Ethanol; 16 H,Rt1.2 Reagents: Sodium Hydroxide Solvents: Water; Ph 12
  标题:Preparation Of 1,6- And 1,8-Naphthyridines As Antiviral Compounds For Treatment Of Hcv Infections
  参考文献:World Intellectual Property Organization]
  
  89-61-2 = 93-67-4
  反应条件:1.1 Reagents: Potassium Hydroxide Solvents: 1-Butanol; Heated1.2 Solvents: 1-Butanol; 1 H,Heated1.3 Reagents: Disodium Sulfide Solvents: Tetrachloroethylene; 8 H,90 - 100 °C
  标题:Effective Method Of Synthesis Of 2-Aryloxy-5-Chloro-Aminobenzene
  作者:Liu,Jingzi; Shi,Dabin; Wang,Yuliang; Chen,Shuhua
  参考文献:Xinan Shifan Daxue Xuebao 日期:2006 卷标:31(6) 页码:84-86]
  
  91-39-4 = 93-67-4
  反应条件:1.1 Reagents: Stannous Chloride
  标题:Synthesis Of 2-Chloro- And 1,4,8-Trichlorodibenzofuran And Their Effects On The Growth Of Mice And On The Liver Microsomal Drug Metabolizing Enzyme Systems Of Rats
  作者:Saeki,Seitaro; Ozawa,Naoki; Yoshimura,Hidetoshi
  参考文献:Fukuoka Igaku Zasshi 日期:1977 卷标:68(3) 页码:96-103]
  
  91-39-4 = 93-67-4
  反应条件:1.1 Reagents: Hydrogen Catalysts: Acetic Acid,Palladium Solvents: Ethanol; 12 H,60 Psi,Rt
  标题:Asymmetric Hydrogenation Of Dibenzo-Fused Azepines With Chiral Cationic Ruthenium Diamine Catalysts
  作者:Yi,Zi-Qi; Deng,Bo-Wen; Chen,Fei; He,Yan-Mei; Fan,Qing-Hua
  参考文献:New Journal Of Chemistry 日期:2023 卷标:47(24) 页码:11492-11497]
  
  = 93-67-4 [标题:Reaction Conditions
  标题:New Spermine And Spermidine Derivatives As Potent Inhibitors Of Trypanosoma Cruzi Trypanothione Reductase
  作者:Bonnet,Beatrice; Soullez,David; Davioud-Charvet,Elisabeth; Landry,Valerie; Horvath,Dragos; Et Al
  参考文献:Bioorganic & Medicinal Chemistry 日期:1997 卷标:5(7) 页码:1249-1256]
  
  = 93-67-4 [标题:Reaction Conditions
  标题:Preparations Of ω-Aminosubstituted-Acetamidodiphenyl Ether Derivatives And Their Pharmacological Actions
  作者:Hamada,Yoshiki; Sugiura,Michiharu; Nishina,Takashi; Araki,Kazunori; Horigome,Kazutoshi; Et Al
  参考文献:Yakugaku Zasshi 日期:1978 卷标:98(12) 页码:1597-606]
  
  = 93-67-4 [标题:Reaction Conditions
  标题:Aminodiphenyl Ethers
  参考文献:German Democratic Republic

海关参考信息

• 2903919090-氯苯
  2908191000-对氯苯酚
  2908999090-其他酚的硝化衍生物
  2918290000-其他含酚基羧酸
• 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
• 详情请参考：📖 海关编码查询和海关进出口税则

专利信息

其他信息查阅

• ➥ 象形图和危险代码
• ➥ 防范代码详解
• ➥ 危险代码说明
• ➥ Globally Harmonized System
• ➥ REACH监管