CAS: 92-79-5; 3-Hydroxy-N-(4-Methoxyphenyl)-2-Naphthamide

该化合物是一种属于氯化萘衍生物类别的化学化合物,其主干架与氢氧基组和氨化功能组相替代,有助于其潜在的生物活动;甲基氧基组的存在增强了其亲脂性,有可能影响其溶解性和与生物膜的相互作用;该化合物可能表现出各种药理特性,包括防炎或止痛作用,尽管具体的生物活动可能因结构改变和其他子组的存在而不同;其分子结构结构允许与氢氧基组结合氢,这可在其与其它分子的再活动及互动方面发挥作用;与许多有机化合物一样,应当注意到适当的处理和安全措施,因为如果不正确管理,可能会对健康造成风险.通常需要进一步研究,以充分阐明其在医药化学方面的特性和潜在用途.

结构式图片

物理性质

MSDS等安全信息

欧盟法规

REACH注册ECHA物质C&L通报REACH预注册

上下游产品

CAS号104-94-9 对甲氧基苯胺 | CAS号92-70-6 2-羟基-3-萘甲酸 | CAS号1734-00-5 3-hydroxy-2-nap... | CAS号2284-20-0 4-甲氧基苯基 异硫氰酸酯

合成工艺路线路线简述

  • 92-70-6 = 92-79-5
    反应条件:1.1 Reagents: Phosphorus Trichloride Solvents: Chlorobenzene; Rt; 10 Min,100 °C; 15 Min,120 °C; 20 Min,130 °C
    标题:Antibacterial And Herbicidal Activity Of Ring-Substituted 3-Hydroxynaphthalene-2-Carboxanilides
    作者:Kos,Jiri; Zadrazilova,Iveta; Pesko,Matus; Keltosova,Stanislava; Tengler,Jan; Et Al
    参考文献:Molecules 日期:2013 卷标:18 页码:7977-7997]

    = 92-79-5 [标题:Reaction Conditions
    标题:Benzamide,Naphthalenecarboxamide,Arylacetamide,Arenesulfonamide,Carbamate,Thiocarbamate,And Benzylamine Inhibitors Of Inosine-5'-Monophosphate Dehydrogenase
    参考文献:World Intellectual Property Organization]

    92-70-6 = 92-79-5
    反应条件:1.1 Reagents: Phosphorus Trichloride Solvents: Chlorobenzene; Rt -> 10 °C; 10 °C; 15 Min,135 °C
    标题:Synthesis Of Naphthol As-X Chloroacetates And Study On The Electron Effects On The Human Leukocyte Esterase Staining
    作者:Tran,Van Tinh; Pham,Hoai Thu; Nguyen,Anh Tri; Luu,Van Boi
    参考文献:Tap Chi Hoa Hoc 日期:2011 卷标:49(4) 页码:479-488]

    92-70-6 = 92-79-5
    反应条件:1.1 Reagents: Oxygen Catalysts: B-(2-Iodophenyl)Boronic Acid Solvents: Toluene; Rt; 20 H,Reflux
    标题:Preparation Method Of Naphthol As-Series Anilide Dye
    参考文献:China]

    92-70-6 = 92-79-5
    反应条件:1.1 Reagents: Phosphorus Trichloride Solvents: Chlorobenzene; 15 Min,Heated
    标题:Investigation Of Hydro-Lipophilic Properties Of N-Alkoxyphenylhydroxynaphthalenecarboxamides
    作者:Kapustikova,Iva; Bak,Andrzej; Gonec,Tomas; Kos,Jiri; Kozik,Violetta; Et Al
    参考文献:Molecules 日期:2018 卷标:23(7)]

    92-70-6 = 92-79-5
    反应条件:1.1 Reagents: Phosphorus Oxychloride Solvents: Chlorobenzene; Rt; Rt -> 130 °C; 25 Min,130 °C
    标题:Preparation And Biological Properties Of Ring-Substituted 3-Hydroxynaphthalene-2-Carboxanilides
    作者:Kos,Jiri; Zadrazilova,Iveta; Pesko,Matus; Pavlica,Jiri; Gonec,Tomas; Et Al
    参考文献:International Electronic Conference On Synthetic Organic Chemistry 日期:2012]

    92-70-6 = 92-79-5
    反应条件:1.1 Reagents: Thionyl Chloride; Rt; 1 H,Reflux1.2 Solvents: Tetrahydrofuran; 1 H,Reflux; Reflux -> Rt1.3 Reagents: Hydrochloric Acid Solvents: Dichloromethane,Water; 30 Min,Rt
    标题:Structure-Activity Relationship Studies Of Naphthol As-E And Its Derivatives As Anticancer Agents By Inhibiting Creb-Mediated Gene Transcription
    作者:Li,Bingbing X.; Yamanaka,Kinrin; Xiao,Xiangshu
    参考文献:Bioorganic & Medicinal Chemistry 日期:2012 卷标:20(23) 页码:6811-6820]

    92-70-6 = 92-79-5
    反应条件:1.1 Reagents: Phosphorus Trichloride Solvents: Chlorobenzene; 10 Min,100 °C; 15 Min,120 °C; 20 Min,130 °C
    标题:3-Hydroxynaphthalene-2-Carboxanilides And Their Antitrypanosomal Activity
    作者:Kos,Jiri; Kapustikova,Iva; Clements,Carol; Gray,Alexander I.; Jampilek,Josef
    参考文献:Monatshefte Fuer Chemie 日期:2018 卷标:149(5) 页码:887-892]

    = 92-79-5 [标题:Reaction Conditions
    标题:Aryl Amides Of 2-Hydroxy-3-Naphthoic Acid
    参考文献:Czechoslovakia
📜2-羟基-3-萘甲酸置于氯化亚砜体系中,用 四氢呋喃 作为反应溶剂,化学反应 2.0H,反应生成 色酚as-Rl
参考文献:Structure-activity Relationship Studies Of Naphthol As-E And Its Derivatives As Anticancer Agents By Inhibiting Creb-Mediated Gene Transcription
标题:Structure-activity Relationship Studies Of Naphthol As-E And Its Derivatives As Anticancer Agents By Inhibiting Creb-Mediated Gene Transcription
摘要:Creb (Cyclic Amp-Response Element Binding Protein) Is A Downstream Transcription Factor Of A Multitude Of Signaling Pathways Emanating From Receptor Tyrosine Kinases Or G-Protein Coupled Receptors. Creb Is Not Activated Until It Is Phosphorylated At Ser133 And Its Subsequent Binding To Creb-Binding Protein (Cbp) Through Kinase-Inducible Domain (Kid) In Creb And Kid-Interacting (Kix) Domain In Cbp. Tumor Tissues From Various Organs Present Higher Level Of Expression And Activation Of Creb. Thus Creb Has Been Proposed As A Promising Cancer Drug Target. We Previously Described Naphthol As-E (1A) As A Small Molecule Inhibitor Of Creb-Mediated Gene Transcription In Living Cells. Here We Report The Structure-Activity Relationship (Sar) Studies Of La By Modifying The Appendant Phenyl Ring. All The Compounds Were Evaluated For In Vitro Inhibition Of Kix-Kid Interaction,Cellular Inhibition Of Creb-Mediated Gene Transcription And Inhibition Of Proliferation Of Four Cancer Cell Lines (A549,Mcf-7,Mda-Mb-231 And Mda-Mb-468). Sar Indicated That A Small And Electron-Withdrawing Group Was Preferred At The Para-Position For Kix-Kid Interaction Inhibition. Compound La Was Selected For Further Biological Characterization And It Was Found That La Down-Regulated The Expression Of Endogenous Creb Target Genes. Expression Of A Constitutively Active Creb Mutant,Vp16-Creb In Mcf-7 Cells Rendered The Cells Resistant To La,Suggesting That Creb Was Critical In Mediating Its Anticancer Activity. Furthermore,La Was Not Toxic To Normal Human Cells. Collectively,These Data Support That La Represents A Structural Template For Further Development Into Potential Cancer Therapeutics With A Novel Mechanism Of Action. (C) 2012 Elsevier Ltd. All Rights Reserved.
DOI:10.1016/j.Bmc.2012.09.056

海关参考信息

专利信息


专利号:US-4785082-A
优先权日:1984-11-06
标 题:Process for preparing a highly concentrated aqueous press cakes of an azo disperse dye from dilute aqueous suspension thereof wherein surfactant is added before the dye is isolated
发明人：WEIDE JOACHIM; DIETZ ERWIN; DEUBEL REINHOLD
权利人:HOECHST AG
摘要:According to the invention, addition of one or more surfactants having a cloud point in aqueous solution to an aqueous suspension of an azo disperse dye gives after the isolation of the dye at a temperature above the cloud point aqueous press cakes containing a large amount of this dye. n The direct processing of press cakes as obtained for example after the synthesis and isolation of azo disperse dyes to practical dispersions for use requires a minimum dye content in the press cakes. The minimum content is frequently not obtained when conventional methods of isolation are used, so that it is necessary to proceed via the indirect route of drying to obtain powders and redispersing the powders. By using the process according to the invention it is possible to cut out the costly indirect route or, if desired, to reduce the expense of drying to obtain powders by an appreciable margin.

其他信息查阅

供应商参考报价(招募中)

品牌试剂参考报价(招募中)

实用工具

⚠️全国化工行业净网倡议书
📋制造商识别码
📖 海关编码查询
📝MSDS生成器

📌 第三方产品分析报告

✅ COA系统入驻 | 共享模式

合成参考文献


参考文献:10.1016/j.bbrc.2023.08.050
摘要:Ikeda Y, Davis MI, Sumita K, Zheng Y, Kofuji S, Sasaki M, Hirota Y, Pragani R, Shen M, Boxer MB, Takeuchi K, Senda T, Simeonov A, Sasaki AT. Multimodal action of KRP203 on phosphoinositide kinases in vitro and in cells. Biochemical and Biophysical Research Communications. 2023 Oct;679():116–21. doi: 10.1016/j.bbrc.2023.08.050.
📝 需求与反馈
尽可能描述清楚需求与问题信息
×

通知