CAS: 915087-25-1; 4-Amino-2-Fluoro-N-Methylbenzamide

上下游产品

N-甲基-2-氟-4-硝基苯甲酰胺 2-Fluoro-N-Methyl-4-Nitrobenzamide 915087-24-0
2-Fluoro-4-(4-Methoxybenzylamino)-N-Methylbenzamide 956104-46-4
2,4-Difluoro-N-Methylbenzamide 948717-18-8

2,4-二氟苯甲酰氯置于三氟乙酸体系中,用 四氢呋喃,二氯甲烷,乙腈 作为反应溶剂,化学反应 0.33H,反应生成 4-氨基-2-氟-N-甲基苯甲酰胺
参考文献:Substituted Diazaspiroalkanes As Androgen Receptor Modulators
标题:Substituted Diazaspiroalkanes As Androgen Receptor Modulators
摘要:这项发明提供了formula Ii的化合物:其中a,B,Het,R1,R2和r3如本文所述.这些化合物是雄激素受体调节剂,用于治疗雄激素受体相关疾病.

专利信息

专利号:US-9926291-B2
优先权日:2007-03-27
标 题 :Synthesis of thiohydantoins
发明人：OUERFELLI OUATHEK; DILHAS ANNA; YANG GUANGBIN; ZHAO HONG
权利人:SLOAN KETTERING INST CANCER RES
摘要:A novel synthesis of the anti-androgen, A52, which has been found to be useful in the treatment of prostate cancer, is provided. A52 as well as structurally related analogs may be prepared via the inventive route. This new synthetic scheme may be used to prepare kilogram scale quantities of pure A52.

专利号:US-10626091-B2
优先权日:2014-10-01
标 题 :Process for the preparation of enzalutamide
发明人：CHIVUKULA KAMESWAR RAO; KARUTURI VEERA VENKATESWARA RAO; BENDA SRINIVAS; ANKE RAMACHANDRA; GAJULA DHARMAPURI; MOTURU VENKATA RAMA KRISHNA MURTHY; INDUKURI VENKATA SUNIL KUMAR; GORANTLA SEETA RAMA ANJANEYULU; CHAVA SATYANARAYANA
权利人:LAURUS LABS LTD
摘要:The present invention relates to an improved process for the preparation of enzalutamide by conventional synthesis, which avoids utilization of microwave irradiation and noxious reagents. The present invention also relates to an improved process for preparation of 4-isothiocyanato-2-(trifluoromethyl) benzonitrile, which is an intermediate in the synthesis of Enzalutamide.

专利号:US-2017190670-A1
优先权日:2014-07-11
标题:Improved process for the preparation of enzalutamide
发明人：HIRPARA SANJAY; SHRAWAT VIMAL KUMAR; POTHURAJU RAJU; TRIPATHI CHANDRESH KUMAR; AKSHAYKANT CHATURVEDI
权利人:SHILPA MEDICARE LTD
摘要:The present application relates to an improved process for preparation of Enzalutamide (I). n n n n n n n n n n The present application also relates to an improved process for the preparation of substantially pure Enzalutamide (I) having purity of greater than 99.5%. n The present application also relates to a novel process for the preparation of Enzalutamide intermediate useful in the industrially viable synthesis of Enzalutamide.

专利号:WO-2008119015-A2
优先权日:2007-03-27
标 题 :Synthesis of thiohydantoins

专利号:US-8987452-B2
优先权日:2007-03-27
标 题:Synthesis of thiohydantoins

专利号:US-2010190991-A1
优先权日:2007-03-27
标题 :Synthesis of thiohydantoins