📜2-氨基-3-甲基吡啶置于氢溴酸,溴,碘,Magnesium,Sodium Nitrite体系中,化学反应 5.0H,反应生成 2-乙酰基-3-甲基吡啶
参考文献:Compounds With Bridgehead Nitrogen: 45-the1H NMR Spectra And Stereochemistry Of Some Dimethylperhydro-Oxazolo[3,4-A]Pyridines
标题:Compounds With Bridgehead Nitrogen: 45-the1H NMR Spectra And Stereochemistry Of Some Dimethylperhydro-Oxazolo[3,4-A]Pyridines
摘要:Abstractthe Positions Of Conformational Equilibria In 1,5‐,1‐6‐ And 1,8‐dimethylperhydro‐oxazolo[3,4‐a]Pyridines Were Determined By 1H NMR Spectroscopy. The Cis‐(H‐5,H‐8A)‐1,6‐dimethyl‐perhydro‐oxazolo[3,4‐a]Pyridine. In Contrast,R‐1,T‐6,T‐8A‐1,6‐dimethylperhydro‐oxazolo[3,4‐ A]Pyridine Preferred The Cis‐fused Conformation. Three Of The 1,8‐dimethylperhydro‐oxazolo[3,4‐a]Pyridines Adopted The Trans‐fused Conformations (With Distortion Of The System In The Case Of The R‐1,C‐8,C‐8A Derivative) And The R‐1,C‐8,T‐8A‐1,8‐dimethyl Derivative Adopted The Cis‐fused Conformation.
DOI:10.1002/mrc.1270200411