CAS: 84050-22-6; 6,7-Dimethoxy-2-(Piperazin-1-yl)Quinazolin-4-Amine Hydrochloride

该化合物是作为动脉抑制剂,其结构特征,包括管状基和氧基替代成分,有助于其选择性结合,并由于盐盐的形式,水介质中的溶性增强.该化合物对药用化学研究具有兴趣,因为它有可能用于特定信号路径. 4-amino组的存在和6-7-dimethomoxy安排可以进一步优化其与生物目标的互动,使其成为发展治疗剂的宝贵中间体.其定义明确的化学特性确保了实验环境中的再生性.

英文名称6,7-Dimethoxy-2-(Piperazin-1-yl)Quinazolin-4-Amine Hydrochloride
中文名称2-哌嗪基-4-氨基-6,7-二甲氧基喹唑啉盐酸盐
IUPAC名称6,7-dimethoxy-2-(piperazin-1-yl)quinazolin-4-amine hydrochloride
其它别名2-Piperazinyl-4-Amino-6,7-Dimethoxyquinazolinehcl; 4-Amino-2-Piperazin-6,7-Dimethoxyquinolinehydrochloride; 2-Piperazinyl-6,7-Dimethoxyquinazolin-4-Amine Hydrochlorode; Piperazine Amino Dimethoxy Quinaoline Hydrochloride; 2-Piperazine-4-Amino-6,7-Dimethoxy Quinazoline Hcl; 2-Piperazine-4-Amino-6,7-Dimethoxy Quinoline Hydrochloride; 2-Piperazinyl-4-Amino-6,7-Dimethoxyquinazoline Hydrochloride; 2-Piperazine-4-Amino-6,7-Dimethoxy Quinaoline Hydrochloride
CAS编号84050-22-6
MFCD编号:MFCD03840840
分子式:C14H20ClN5O2分子量:325.8
产品CID: 1828978
产品分类分析化学 → 标准品 → 药典标准品和杂质标准品

相似结构搜索
InChIKey: AUMKUQAWVQJGTR-UHFFFAOYSA-N
InChI=1S/C14H19N5O2.ClH/c1-20-11-7-9-10(8-12(11)21-2)17-14(18-13(9)15)19-5-3-16-4-6-19;/h7-8,16H,3-6H2,1-2H3,(H2,15,17,18);1H
计算化学: 氢键受体数7.0氢键供体数3.0可旋转键数3.0

MSDS等安全信息

警示词Warning
危险描述H302-H315-H319-H335-
防范说明P261-P264-P270-P271-P280-P302+P352-P305+P351+P338-P312-P330-P362-P403+P233-P501-

上下游产品

CAS号23680-84-4 4-氨基-2-氯-6, 7-二氧基喹唑啉 | CAS号84050-21-5 4-amino-6,7-dim...

合成工艺路线路线简述

📜2-氯-4-氨基-6,7-二甲氧基喹唑啉置于盐酸体系中,用异戊醇作为反应溶剂,化学反应 2.5H,反应生成 2-哌嗪基-4-氨基-6,7-二甲氧基喹唑啉盐酸盐
参考文献:Pyrimidine Derivatives. 4. Synthesis And Antihypertensive Activity Of 4-Amino-2-(4-Cinnamoylpiperazino)-6,7-Dimethoxyquinazoline Derivatives
标题:Pyrimidine Derivatives. 4. Synthesis And Antihypertensive Activity Of 4-Amino-2-(4-Cinnamoylpiperazino)-6,7-Dimethoxyquinazoline Derivatives
摘要:A Series Of 30 4-Amino-2-(4-Cinnamoylpiperazino)-6,7-Dimethoxyquinazoline Derivatives Was Prepared And Tested For Their Ability To Reduce Blood Pressure In Conscious,Spontaneously Hypertensive Rates (Shr). A Number Of These Compounds,Notably 4-Amino-2-(4-Cinnamoylpiperazino)-6,7-Dimethoxyquinazolines 3A (R1 = H; R2 = Ph),3J (R1 = H; R2 = 4-Etoph),And 5A (R1 = H; R2 = 2-Furyl),Showed Activity At Oral Doses Of 0.3-10 Mg/kg. The Effects Of The 4-Substituents Of The Piperazino Group On Activity Are Discussed. Compounds 3A,3J,And 5A Were Effective In Renal Hypertensive Rats At Oral Doses Of 3 And 10 Mg/kg And Showed Alpha-Adrenoceptor Blocking Effects In Isolated Aortas Of Rats. A 5-Day Consecutive Oral Administration Of 3A And 3J In Shr Did Not Lead To Development Of Tolerance.
DOI:10.1021/jm00357A016