CAS: 81907-62-2; (2R,6R)-6-[(5R,7S,10S,13R,14R,15S,17R)-7,15-Dihydroxy-4,4,10,13,14-Pentamethyl-3,11-Dioxo-2,5,6,7,12,15,16,17-Octahydro-1H-Cyclopenta[a]Phenanthren-17-Yl]-2-Methyl-4-Oxoheptanoic Acid

该化合物是一种三叶类化合物,主要产自Ganoderma晶蘑菇的果实体,通常称为reishi或Lingzhi,其特点是复杂的分子结构,包括多环和功能组,有助于其生物活性.该化合物具有一系列药理特性,包括抗炎,抗氧化剂和潜在的抗癌症影响,使其对传统医学和现代药理都感兴趣.甘代尔酸A因其能够调节各种生物途径,包括免疫反应和细胞信号,其溶解性一般在水中较低,但可溶解于有机溶剂,这是许多三肢类的典型特征.该化合物的安全特征和治疗潜力仍然是研究的主题,突出其在天然产品和医药化学领域的重要性.

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    海关参考信息

    专利信息


    专利号:US-6726911-B1
    优先权日:1999-03-09
    标 题 :Biologically active compounds of Ganoderma pfeifferi DSM 13239
    发明人:JUELICH WOLF; LINDEQUIST ULRIKE; JANSEN ROLF; MOTHANA RAMZI
    权利人:GANOMYCIN
    摘要:The present invention relates to novel biologically active compounds from fungi of the species Ganoderma pfeifferi DSM 13239, processes for their preparation, and their use. From the fruit body and mycelium of the species Ganoderma pfeifferi DSM 13239, extracts can be obtained which have antimicrobial activity and are suitable as preserving agents, for pharmaceutical and cosmetic preparations, for controlling infections, and for use in fish breeding. Antimicrobially active substances called ganomycins having activity against multiresistant germs are isolated from the extracts. The total synthesis of the ganomycins and their derivatization enables their use an antibiotics.

    专利号:US-2004018210-A1
    优先权日:2001-01-31
    标 题 :Cholesterol-lowering agent
    发明人:HAJJAJ HASSAN; MACE CATHERINE; NIEDERBERGER PETER; FAY LAURENT-BERNARD
    摘要:A hypocholesterolaemic agent and a process for its preparation by extraction from edible fungi, along with methods of use of the agent for preventing the synthesis of cholesterol in a person. These methods include the administration of the agent alone or in a food or beverage. The foods or beverages that contain this agent are another feature of the invention.

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    ✅ COA系统入驻 | 共享模式

    主要参考文献


    1: Yajima Y, Miyazaki M, Okita N, Hoshino T. Production of Ginkgo leaf-shaped basidiocarps of the Lingzhi or Reishi medicinal mushroom Ganoderma lucidum (higher Basidiomycetes), containing high levels of α- and β-D-glucan and ganoderic acid A. Int J Med Mushrooms. 2013;15(2):175-82.

    合成参考文献


    参考文献:10.17219/acem/137914
    摘要:Wang T, Lu H. Ganoderic acid A inhibits ox-LDL-induced THP-1-derived macrophage inflammation and lipid deposition via Notch1/PPARγ/CD36 signaling. Adv Clin Exp Med. 2021 Oct;30(10):1031–41. doi: 10.17219/acem/137914.
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