专利号:US-6726911-B1 优先权日:1999-03-09 标 题 :Biologically active compounds of Ganoderma pfeifferi DSM 13239 发明人:JUELICH WOLF; LINDEQUIST ULRIKE; JANSEN ROLF; MOTHANA RAMZI 权利人:GANOMYCIN 摘要:The present invention relates to novel biologically active compounds from fungi of the species Ganoderma pfeifferi DSM 13239, processes for their preparation, and their use. From the fruit body and mycelium of the species Ganoderma pfeifferi DSM 13239, extracts can be obtained which have antimicrobial activity and are suitable as preserving agents, for pharmaceutical and cosmetic preparations, for controlling infections, and for use in fish breeding. Antimicrobially active substances called ganomycins having activity against multiresistant germs are isolated from the extracts. The total synthesis of the ganomycins and their derivatization enables their use an antibiotics.
专利号:US-2004018210-A1 优先权日:2001-01-31 标 题 :Cholesterol-lowering agent 发明人:HAJJAJ HASSAN; MACE CATHERINE; NIEDERBERGER PETER; FAY LAURENT-BERNARD 摘要:A hypocholesterolaemic agent and a process for its preparation by extraction from edible fungi, along with methods of use of the agent for preventing the synthesis of cholesterol in a person. These methods include the administration of the agent alone or in a food or beverage. The foods or beverages that contain this agent are another feature of the invention.
1: Yajima Y, Miyazaki M, Okita N, Hoshino T. Production of Ginkgo leaf-shaped basidiocarps of the Lingzhi or Reishi medicinal mushroom Ganoderma lucidum (higher Basidiomycetes), containing high levels of α- and β-D-glucan and ganoderic acid A. Int J Med Mushrooms. 2013;15(2):175-82.
合成参考文献
参考文献:10.17219/acem/137914 摘要:Wang T, Lu H. Ganoderic acid A inhibits ox-LDL-induced THP-1-derived macrophage inflammation and lipid deposition via Notch1/PPARγ/CD36 signaling. Adv Clin Exp Med. 2021 Oct;30(10):1031–41. doi: 10.17219/acem/137914.