CAS: 673-66-5; Azocan-2-One

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2210-12-0 40033-49-6 88948-35-0

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CAS号502-42-1 环庚酮 | CAS号2158-31-8 环庚酮肟 | CAS号613688-07-6 ((((7-azidohept... | CAS号929-17-9 7-氨基庚酸 | CAS号103039-86-7 1-ethylaz°Can-2-one | CAS号135920-28-4 7-Azidoheptanoi... | CAS号27482-18-4 1,1-bis(methylt... | CAS号1889-08-3 1-methylaz°Can-2-one | CAS号110967-05-0 1-isopropyl°Cta... | CAS号929-17-9 7-氨基庚酸 | CAS号19243-04-0 7-氨基-1-庚醇 | CAS号2056-41-9 1-(2-chloroethy... | CAS号2056-40-8 2-(az°Can-1-yl)... | CAS号1889-08-3 1-methylaz°Can-2-one | CAS号26228-96-6 3,3-dichloroazo... | CAS号5227-53-2 氮杂环庚烷-2-甲酸 | CAS号103039-86-7 1-ethylaz°Can-2-one | CAS号1121-92-2 七甲亚胺 | CAS号628-62-6 庚酰胺

环庚酮肟置于ethyl 2-Cyano-2-(2-Nitrobenzenesulfonyloxyimino)Acetate体系中,用 乙腈 作为反应溶剂,以71%的收率获得产物氮杂环辛酮
参考文献:乙基2-氰基-2-(2-硝基苯磺酰氧基亚氨基)乙酸酯(邻-Nosyloxy)介导的微波辐射下酮肟的双贝克曼重排:机械感知.
标题:乙基2-氰基-2-(2-硝基苯磺酰氧基亚氨基)乙酸酯(邻-Nosyloxy)介导的微波辐射下酮肟的双贝克曼重排:机械感知.
摘要:报道了一种在微波辐射下使用2-氰基-2-(2-硝基苯磺酰氧基亚氨基)醋酸乙酯(o-Nosyloxy)进行贝克曼重排的方法.在没有任何路易斯酸或助催化剂的情况下,酮肟(19个实例)可在约10分钟内以69-97%的产率转化为相应的酰胺/内酰胺.这是无卤有机催化贝克曼重排的一个例子.核磁共振(NMR)-和高分辨质谱(hrms)为基础的详细机理研究表明,ô-Nosyloxy充当引发剂.以前基于密度泛函理论(dft)计算报告了此类引发剂.但是,我们在这里报告了两个瞬时中间体(腈离子和腈离子的二聚体)的hrms签名.对反应机理进行了基于NMR的严格研究.我们的结果表明,报告的贝克曼重排通过两个连续的重排进行.
DOI:10.1002/adsc.202001416

专利信息

专利号:US-9957355-B2
优先权日:2013-06-12
标 题 :Device and method for synthesis of a polymer under separation of a gaseous substance
发明人：ZHU NING; STAMMER ACHIM; CLAUSS JOACHIM; KORY GAD
权利人:BASF SE
摘要:The invention relates to a device for synthesis of a polymer under separation of a gaseous substance. Said device comprises a reaction chamber ( 1 ), which has a top section ( 11 ), a middle section ( 12 ) and a bottom section ( 13 ), an inlet opening ( 2 ) which is arranged in the middle section ( 12 ), a first outlet opening ( 3 ) which is arranged in the bottom section ( 13 ), a second outlet opening ( 4 ) which is arranged in the top section ( 11 ), a first return opening ( 51 ), which is arranged in the bottom section ( 13 ), a second outlet opening ( 52 ), which is arranged under the top section ( 11 ), a distribution device ( 6 ), which is arranged between the top section ( 11 ) and the middle section ( 12 ), and a removal device ( 7 ) which is arranged to be movable along the top section ( 11 ). The invention further relates to a method for synthesis of a polymer which can be carried out in said device.

专利号:US-8735586-B2
优先权日:2007-06-26
标 题 :Regioselective copper catalyzed synthesis of benzimidazoles and azabenzimidazoles
发明人：ALONSO JORGE; LINDENSCHMIDT ANDREAS; NAZARÉ MARC; URMANN MATTHIAS; HALLAND NIS; RKYEK OMAR
权利人:ALONSO JORGE; LINDENSCHMIDT ANDREAS; NAZARÉ MARC; URMANN MATTHIAS; HALLAND NIS; RKYEK OMAR; SANOFI SA
摘要:The present invention relates to a process for the regioselective synthesis of compounds of the formula I, n nwherein R0; R1; R2; R3; R4; R5; A1; A2; A3; A4, Q and J have the meanings indicated in the claims. The present invention provides a direct copper catalyzed regioselective process to a wide variety of unsymmetrical, multifunctional N-substituted benzimidazoles or azabenzimidazoles of formula I starting from 2-halo-nitroarenes and N-substituted amides.

专利号:US-8283476-B2
优先权日:2007-06-26
标 题:Transition metal catalyzed synthesis of 2H-indazoles
发明人：HALLAND NIS; NAZARE MARC; LINDENSCHMIDT ANDREAS; ALONSO JORGE; RKYEK OMAR; URMANN MATTHIAS
权利人:HALLAND NIS; NAZARE MARC; LINDENSCHMIDT ANDREAS; ALONSO JORGE; RKYEK OMAR; URMANN MATTHIAS; SANOFI SA
摘要:The present invention relates to a process for the regioselective synthesis of compounds of the formula I, n nwherein R0; R1; R2; R3; R4; R5; A1; A2; A3; A4, Q and J have the meanings indicated in the claims. The present invention provides a direct transition metal catalyzed process to a wide variety of multifunctional 2H-indazoles or 2H-azaindazoles of the formula (I) from 2-halo-phenylacetylenes or (2-sulfonato)phenylacetylenes and monosubstituted hydrazines.

专利号:US-4422970-A
优先权日:1982-05-20
标题 :Method of synthesis of 1-dodecylazacycloheptan-2-one
发明人：RAJADHYAKSHA VITHAL J; PECK JAMES V; MINASKANIAN GEVORK
权利人:NELSON RES & DEV
摘要:In a method of synthesis of 1-substituted azacycloalkan-2-ones with primary alkyl halides and aralkyl halides as alkylating agents, the improvement comprising carrying out the N-alkylation in the presence of a phase transfer catalyst having the structural formula where X is suitable anion; and R1, R2, R3 and R4 are each alkyl or aralkyl groups having 1-18 carbon atoms, or R2, R3 and R4 can form a part of a heterocyclic ring, with the proviso that the combined total of carbon atoms is between 16 and 40.

专利号:US-8026375-B2
优先权日:2007-04-13
标题:Transition metal catalyzed synthesis of N-aminoindoles
发明人：HALLAND NIS; NAZARE MARC; LINDENSCHMIDT ANDREAS; RKYEK OMAR; URMANN MATTHIAS; ALONSO JORGE
权利人:SANOFI AVENTIS
摘要:The present invention relates to a process for the regioselective synthesis of compounds of the formula I, n nwherein R0; R1; R2; R3; R4; R5; R6; A1; A2; A3; A4, Q, T and J have the meanings indicated in the claims. The present invention provides a direct transition metal catalyzed process to a wide variety of multifunctional N-aminoindole or N-amino-azaindoles of the formula I from 2-halo-phenylacetylenes or (2-sulfonato)phenyl-acetylenes and N,N-disubstituted hydrazines, useful for the production of pharmaceuticals, diagnostic agents, liquid crystals, polymers, herbicides, fungicidals, nematicidals, parasiticides, insecticides, acaricides and arthropodicides.

专利号:US-8188282-B2
优先权日:2006-07-15
标 题:Regioselective palladium catalyzed synthesis of benzimidazoles and azabenzimidazoles
发明人：ALONSO JORGE; LINDENSCHMIDT ANDREAS; NAZARE MARC; HALLAND NIS; RKYEK OMAR; URMANN MATTHIAS
权利人:ALONSO JORGE; LINDENSCHMIDT ANDREAS; NAZARE MARC; HALLAND NIS; RKYEK OMAR; URMANN MATTHIAS; SANOFI AVENTIS
摘要:The present invention relates to a process for the regioselective synthesis of compounds of the formula I, n nwherein R0; R1; R2; R3; R4; R5; A1; A2; A3; A4, Q and J have the meanings indicated in the claims. The present invention provides a direct palladium catalyzed, regioselective process to a wide variety of unsymmetrical, multifunctional N-substituted benzimidazoles or azabenzimidazoles of formula I starting from 2-halo-nitroarenes and N-substituted amides useful for the production of pharmaceuticals, diagnostic agents, liquid crystals, polymers, herbicides, fungicidals, nematicidals, parasiticides, insecticides, acaricides and arthropodicides.