CAS: 64-77-7; N-(Butylcarbamoyl)-4-Methylbenzenesulfonamide

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CAS号4083-64-1 对甲基苯磺酰异氰酸酯 | CAS号109-73-9 正丁胺 | CAS号39078-72-3 S-methyl N-buty... | CAS号70-55-3 对甲苯磺酰胺 | CAS号39764-19-7 N-butylbenzotri... | CAS号27095-02-9 hydroxyethyl ca... | CAS号111-36-4 异氰酸正丁酯 | CAS号4932-55-2 1-butyl-3-(4-me... | CAS号1792-17-2 1,3-二丁基脲 | CAS号18522-92-4 Sodium p-toluen... | CAS号592-31-4 丁基脲 | CAS号613-33-2 4,4'-二甲基联苯 | CAS号108-88-3 甲苯 | CAS号5719-85-7 4-羟基甲苯磺丁脲 | CAS号1515-72-6 N-丁基邻苯二甲酰亚胺 | CAS号70-55-3 对甲苯磺酰胺 | CAS号36323-21-4 N-(butylcarbamo... | CAS号3083-88-3 Urea,N-butyl-N'... | CAS号1119-49-9 N-丁基乙酰胺 | CAS号1888-33-1 N-乙酰基对甲苯磺酰胺

N-(4-Methylphenylsulfonyl)-N'-Butylthiourea置于sodium Hydroxide,双氧水体系中,化学反应生成 甲苯磺丁脲
参考文献:Onisi,Yakugaku Zasshi/journal Of The Pharmaceutical Society Of Japan,1959,Vol. 79,P. 559,564
标题:Onisi,Yakugaku Zasshi/journal Of The Pharmaceutical Society Of Japan,1959,Vol. 79,P. 559,564

专利信息

专利号:US-10005720-B2
优先权日:2013-04-05
标题:Compounds useful for the treatment of metabolic disorders and synthesis of the same
发明人：SEXTON JONATHAN Z; BRENMAN JAY E; MUSSO DAVID L
权利人:NORTH CAROLINA CENTRAL UNIV; UNIV NORTH CAROLINA CHAPEL HILL
摘要:The present invention provides compounds of Formula (I): wherein variables X, Y, Z and R1 are as described herein. Some of the compounds described herein are glutamate dehydrogenase activators. The invention is also directed to pharmaceutical compositions comprising these compounds, uses of these compounds and compositions in the treatment of metabolic disorders as well as synthesis of the compounds.

专利号:WO-9502566-A1
优先权日:1993-07-16
标题 :Synthesis of combinatorial arrays of organic compounds through the use of multiple component combinatorial array syntheses
发明人：ARMSTRONG ROBERT W
权利人:UNIV CALIFORNIA; ARMSTRONG ROBERT W
摘要:The present invention relates to an array of compounds having a common core structure wherein the compounds of the array comprise the products of a multiple component combinatorial array synthesis having at least three components. The present invention also relates to the method of synthesizing that array. A further embodiment of the present invention relates to the use of solid phase synthesis to synthesize the combinatorial array of compounds. The present invention also relates to a method of creating a combinatorial array of compounds with a common core structure by identifying the desired core structure, identifying an MCCA reaction capable of generating that core structure, followed by preparing an array of compounds using the identified MCCA reaction according to the aforementioned method. The present invention also relates to a method for conducting in vitro assays of biological material using the combinatorial arrays of the present invention.

专利号:US-2008287407-A1
优先权日:2003-12-10
标题 :Nitric Oxide Releasing Pyruvate Compounds, Compositions and Methods of Use
发明人：GARVEY DAVID S; FANG XINQIN; KHANAPURE SUBHASH P; RANATUNGA RAMANI R; WEY SHIOW-JYI
权利人:NITROMED INC
摘要:The invention describes novel nitrosated and/or nitrosylated pyruvate compounds and pharmaceutically acceptable salts thereof, and novel compositions comprising at least one nitrosated and/or nitrosylated pyruvate compound, and, optionally, at least one compound that donates, transfers or releases nitric oxide, stimulates endogenous synthesis of nitric oxide, elevates endogenous levels of endothelium-derived relaxing factor or is a substrate for nitric oxide synthase, and/or at least one therapeutic agent. The invention also provides novel compositions comprising at least one pyruvate compound and at least one compound that donates, transfers or releases nitric oxide, elevates endogenous levels of endothelium-derived relaxing factor, stimulates endogenous synthesis of nitric oxide or is a substrate for nitric oxide synthase and/or at least one therapeutic agent. The invention also provides novel kits comprising at least one pyruvate compound, that is optionally nitrosated and/or nitrosylated, and, optionally, at least one nitric oxide donor and/or at least one therapeutic agent. The invention also provides methods for treating diseases resulting from oxidative stress, diabetes, reperfusion injury following ischemia, preservation of tissues, organs, organ parts and/or limbs.

专利号:US-7038037-B2
优先权日:2002-06-20
标题 :Method for sequential support-bound synthesis of conjugated oligomeric compounds
发明人：MAIER MARTIN A; GUZAEV ANDREI P; MANOHARAN MUTHIAH
权利人:ISIS PHARMACEUTICALS INC
摘要:A sequential support-bound synthesis method is disclosed for preparing a conjugated oligomeric compound, preferably a PNA-peptide conjugate or an oligonucleotide-peptide conjugate, using a bridging molecule having at least two N-protecting amino groups. A conjugated oligomeric compound for therapeutic or prophylactic delivery is also disclosed.

专利号:US-2024368164-A1
优先权日:2021-04-28
标 题 :Purine nucleosides, their intermediates, and methods of preparation thereof
发明人：RAVI RAMA SURESH; JACOBSON KENNETH A; POE RUSSELL BIRCH
权利人:ASTROCYLE PHARMACEUTICALS INC; US HEALTH
摘要:The present invention provides purine nucleoside analog compounds and methods of use thereof for treatment of certain injuries, disorders and conditions, for example brain injuries such as stroke or traumatic brain injuries. The present invention further provides methods of synthesizing such compounds, and intermediates useful in the synthesis of such compounds.

专利号:US-9982008-B2
优先权日:2012-06-19
标题 :Preparation and uses of obeticholic acid
发明人：STEINER ANDRÉ; WAENERLUND POULSEN HEIDI; JOLIBOIS EMILIE; REWOLINSKI MELISSA; GROSS RALF; SHARP EMMA; DUBAS-FISHER FIONA; EBERLIN ALEX
权利人:INTERCEPT PHARMACEUTICALS INC
摘要:The present invention relates to obeticholic acid: n nor a pharmaceutically acceptable salt, solvate or amino acid conjugate thereof. Obeticholic acid is useful for the treatment or prevention of a FXR mediated disease or condition, cardiovascular disease or cholestatic liver disease, and for reducing HDL cholesterol, for lowering triglycerides in a mammal, or for inhibition of fibrosis. The present invention also relates to processes for the synthesis of obeticholic acid.