CAS: 57057-80-4; (S)-Ethyl 2-(Tosyloxy)Propanoate

上下游产品

(S)-Ethyl lactate p-toluenesulfonyl chloride(R)-ethyl 2-bromopropanoate (R)-2-(Acetoxy)propionsaeure-ethylester 2-benzoyloxy-propionic acid ethyl ester propionsaeuremethylesterD-(+)-2-4-(2,4-Dichlorphenoxy)-phenoxypropionsaeuremethylester

L(-)-乳酸乙酯 以95的收率获得产物l-(-)-O-对甲苯磺酰基乳酸乙酯
参考文献: Asymmetric Synthesis Of Chiral Secondary Alcohols[fr] Synthese Asymetrique D'Alcools Secondaires Chiraux
标题: Asymmetric Synthesis Of Chiral Secondary Alcohols[fr] Synthese Asymetrique D'Alcools Secondaires Chiraux
摘要:一种使用天然手性分子起始材料合成与杂环核心基团相连的对映纯手性二级醇化合物的方法,该创新性方法特别适用于大规模生产手性二级醇化合物.

专利信息

专利号:US-8101779-B2
优先权日:2008-10-06
标题 :Enantioselective synthesis of (+) and (–)-2-[1-(2,6-dichlorophenoxy)-ethyl]-1,3-diazacyclopent-2-ene
发明人：CROOKS PETER A; VARTAK ASHISH PRAMOD
权利人:CROOKS PETER A; VARTAK ASHISH PRAMOD; UNIV KENTUCKY RES FOUND
摘要:Methods for the enantioselective synthesis of (+) and (−) lofexidine or 2-[1-(2,6)-dichlorophenoxy)-ethyl]-1,3-diazacyclopent-2-ene involve converting (+) or (−) 1-methyl-1-[2,6-dichlorophenoxy]ethanamide to an (+) or (−) imino-ether intermediate by electrophilic attack of the amide oxygen by a trimethoxonium ion and, without isolation, converting the (+) or (−) imino-ether intermediate to (+) or (−) 2-[1-(2,6-dichlorophenoxy)-ethyl]1,3-diazacyclopent-2-ene by adding ethylene diamine; and optionally converting the (+) or (−) 2-[1-(2,6-dichlorophenoxy)-ethyl]1,3-diazacyclopent-2-ene into a pharmaceutically acceptable acid addition salt thereof.

专利号:US-2009162290-A1
优先权日:2005-09-09
标 题 :Method for the synthesis of penta-pendant enantiomer-pure chelators and process for therapeutically active bioconjugates preparation by a covalent binding thereof
发明人：BENES IVAN; CIHELNIK SIMON; DROZ LADISLAV; SRAMEK MARTIN
权利人:THERAPHARM GMBH
摘要:The present invention provides a method for synthesis and binding methods of pentapendant enantiomer-pure chelators of formula (VII) wherein R 1 , R 2 , R 3 , R 4 are groups forming an adequate enantiomer of the chelator; and X 1 -X 5 , Y 1 -Y 5 , Z 1 -Z 5 each individually forming pendant chelating groups.

专利号:US-5629423-A
优先权日:1994-05-16
标题:Asymmetric synthesis of chiral secondary alcohols
发明人：KLEIN J PETER; LEIGH ALISTAIR J; MICHNICK JOHN; KUMAR ANIL M; UNDERINER GAIL E
权利人:CELL THERAPEUTICS INC
摘要:A process for synthesizing enantiomerically pure chiral secondary alcohol compounds linked to a heterocyclic core moiety, using a natural chiral molecule starting material. The inventive process is particularly useful for bulk manufacturing of chiral secondary alcohol compounds.

专利号:WO-9531450-A1
优先权日:1994-05-16
标 题 :Asymmetric synthesis of chiral secondary alcohols

专利号:EP-0759915-A1
优先权日:1994-05-16
标 题 :Asymmetric synthesis of chiral secondary alcohols

专利号:EP-1942949-A1
优先权日:2005-09-09
标 题 :Method for the synthesis of pentapendant enantiomer-pure chelators and process for therapeutically active bio-conjugates preparation by a covalent binding of thereof